The Miami Heat will wait on scan results on a worrying knee injury to Victor Oladipo that soured Saturday's 121-99 victory over the Milwaukee Bucks in Game 3 of their first round series.

Oladipo went down on a drive to the bucket following a foul from Bobby Portis with 3:56 remaining in the fourth quarter, immediately clutching his left knee with an ominous look on his face.

The injury-cursed Heat guard was eventually assisted off the court by Miami's coaching staff, including head coach Erik Spoelstra, with the home court crowd cheering him out.

"We'll just have to see," Spoelstra said. "I feel like throwing up right now, but I don't know what the prognosis is. I want to stay positive on this, and we'll just see what happens."

Oladipo was restricted to only eight games in the 2021-22 season due to injury and only 33 during the 2020-21 campaign across three teams.

The injury soured a win that saw the Eastern Conference eight seed go 2-1 up with home court advantage for Game 4 against the top-seeded Bucks.

"It was a great win, but when you see a player go down like that and particularly a player like Vic, who has gone through so much in the last three years - I don't know what it is right now, so I don't want to jump the gun on anything," Spoelstra said. "But that's definitely not a good feeling to see."

The Bucks-Heat series has been riddled with injuries, with Giannis Antetokounmpo (bruised lower back) and Tyler Herro (broken hand) both unavailable for Game 3.

The Heat's injury concerns got worse with top scorer Jimmy Butler taking a hard fall in the third quarter and exiting the game with a bruised glute after 30 points in 28 minutes.

"He went back to the locker room and said, 'Hey, just give me a couple minutes, I'll be ready to go,'" Spoelstra said.

"I was going to insert him back into the game if it broke 15, but the second unit all night long gave us a tremendous boost."

The Bucks missed MVP candidate Antetokounmpo, shooting 44.7 per cent from the field and gifting 18 turnovers, while Miami scored 46 points in the paint compared to Milwaukee's 36.

"We'll continue to monitor him through the day tomorrow, through the day the next day," Bucks head coach Mike Budenholzer told reporters pre-game about Antetokounmpo's status.

"He's not in a place where he can go, so we'll just continue to monitor and work with him and hope for the best."