Texas A&M-Corpus Christi won 75-71 victory over Southeast Missouri to advance to the NCAA tournament where they will face no.1 seed Alabama in the South Region.
The Islanders held off SEMA in the First Four matchup of no.16 seeds, having led 33-27 at half-time with Jalen Jackson top scoring with 22 points and six rebounds, while Isaac Mushila managed 15 points and 12 rebounds.
The triumph was a first-ever NCAA tournament game win for Texas, who were without guard Terrion Murdix due to a left knee injury.
SEMA had squared the game up at 64-64 with 3:07 to play but could not maintain the rage. Chris Harris top scored for the Redhawks with 23 points.
Pittsburgh also advanced via their First Four game, claiming their first victory at an NCAA tournament since 2014, getting past Mississippi State 60-59 in a see-sawing contest.
Jamarius Burton came up with a go-ahead two-point pointer with 10 seconds remaining and Pitt held on to clinch a clash with no.6 seed Iowa State in the Midwest Regional.
Shakeel Moore missed an open three-pointer to win the game for Mississippi, with D.J. Jeffries unable to convert the tip-in attempt.
Nelly Cummings top scored for the Panthers with 15 points with three rebounds and four assists, while Dashawn Davis also had 15 points with five assists for the Bulldogs.