Luka Doncic will not play for the Dallas Mavericks against the Chicago Bulls after he was ruled out with a right quad strain following Friday's loss to the Milwaukee Bucks.

The three-time All-Star, who currently leads the NBA for points per game with a 32.9 average this season and sits second on the scoring charts outright, complained of pain during his side's 106-105 defeat.

With a three-game home run set to start on Monday against the Oklahoma City Thunder, the call has been made to keep Doncic sidelined for this weekend's trip to United Center.

It is not yet known if there is further reason to be concerned for the point guard, who has been in scintillating form across the campaign so far.

In addition to Doncic, Maxi Kleber and Josh Green will miss Saturday's match with the Bulls, after they also picked up injuries against the Bucks at American Airlines Center.

The forward is out with right foot soreness, while the guard has suffered a right elbow sprain.

The Mavericks arrive in Chicago having suffered their first loss in four, with defeat to the Bucks snapping a three-game victorious run over the New York Knicks, the Phoenix Suns and the Denver Nuggets.

Doncic has topped the points chart for his team in all but one of those games, scoring 33 on Friday in addition to 11 assists and six rebounds. 

His efforts have guided the Mavericks to seventh in the Western Conference this season, with a 13-12 winning record to date.