Dwayne Casey felt his Detroit Pistons side "threw in the towel" as they squandered a 14-point deficit in the final three minutes to lose 142-131 to the Los Angeles Clippers.

The NBA-worst Pistons were on course for just a ninth win in 36 games this season until the Clippers rallied in Monday's contest at Little Caesars Arena.

Paul George scored 32 in the Clippers' overtime triumph, with Terance Mann hitting a tying jumper with five seconds left in regulation to deny the Pistons.

"We were down 15 points in the third quarter, fought our way back, got the lead and had a comfortable lead with three minutes left," Pistons coach Casey said. 

"They threw in the towel. We must learn how to win that game. I'm proud of the way we put ourselves in a position to beat one of the best teams in the West, but we didn't get it."

Clippers coach Tyronn Lue took action with his side 126-112 down by pulling his starters.

A line-up of Luke Kennard, Amir Coffey, Nicolas Batum, Moses Brown and Mann finished the fourth quarter with a 16-2 run in an unlikely turnaround.

"You have to give those guys credit for staying ready," Lue said. "They came out and played with some urgency. 

"Amir and Moses hadn't played in the game, so for them to come in and produce like the way they did was huge."

The Clippers had lost their previous 417 games in which they had trailed by 14 points or more with three minutes remaining prior to Monday's comeback against the Pistons.

Isaiah Stewart, who scored 21 points, says the blame is on the Pistons' players rather than the coaching staff.

"They took their starters out, and we thought the game was over," he said. "We had the lead and we didn't finish the game. That's completely on us, not the coaches."

The Clippers (20-15) are fourth in the Western Conference, while the Pistons (8-28) are bottom of the East.