Joel Embiid exited the Philadelphia 76ers' game against the Toronto Raptors with a wrist injury, leaving Brett Brown waiting to learn how serious it might prove.

Center Embiid left the game in the first half after being hit on the wrist and did not return, the Sixers going on to succumb to a 125-121 loss on Wednesday.

The three-time All-Star, who was returning after sitting out against the Phoenix Suns on Tuesday with an ankle injury, is reportedly not expected to be out long term after X-rays came back negative.

Speaking after the game, 76ers coach Brown said: "I really don't know a lot to share. I do know it was whacked twice. As it relates to what's next, or the evaluation of it, I am sorry, I can't comment on that."

The defeat meant Philadelphia are guaranteed to finish as the number six seed in the Eastern Conference and face the Boston Celtics in the first round of the playoffs.

This season was the first since 2013-14 in which the 76ers had won their season series against the Celtics, who defeated them in the 2018 Eastern Conference semifinals.

Brown is looking forward to the challenge of going up against Boston coach Brad Stevens.

"I've got a lot of respect for Brad. We have had tons of experiences, regular season, playoffs, over the past few years," said Brown.

"I think their team is very unique, in that there is so much firepower at several positions. You know the Philly-Celtics rivalry is historic.

"We are excited and treat this series with tremendous respect. We are excited to compete against them."