Naomi Osaka did not raise a sweat en route to the Miami Open last 16 as Garbine Muguruza moved through but Sofia Kenin and Karolina Pliskova bowed out.
Australian Open champion and second seed Osaka benefited from a walkover after qualifier Nina Stojanovic withdrew ahead of Sunday's clash due to a right thigh injury.
Elise Mertens will face Osaka following the 16th seed's 6-2 0-6 6-2 win against Anett Kontaveit.
Two-time grand slam winner Muguruza rallied past Russian wildcard Anna Kalinskaya at the WTA Premier event.
However, fourth seed Kenin was sent packing as sixth seed Pliskova was tamed by nemesis Jessica Pegula in Miami.
MUGURUZA STAYS HOT
Spanish star Muguruza dug deep to earn her tour-leading 20th win of the season.
Former world number one Muguruza – the 12th seed – prevailed 4-6 6-3 6-4 against Kalinskaya, having trailed 3-0 in the final set.
"I brought my fighting spirit and I could match the level of fighting against Anna, and very happy to go through these tough matches," Muguruza said following two hours, 41 minutes on court.
"Doesn't matter if you play pretty or you play ugly, but you stay strong and you go through these rounds. That gives me an opportunity to feel better and to have another chance."
Muguruza – who has the most final appearances this season with three, having won the Dubai Tennis Championships and finished runner-up at the Qatar Open and Yarra Valley Classic – will next face eighth seed Bianca Andreescu.
Former US Open champion Andreescu overcame fellow seed Amanda Anisimova 7-6 (7-4) 6-7 (2-7) 6-4.
KENIN'S WOES CONTINUE
It has been a rough 2021 for American star Kenin.
Stunned in the second round of the Australian Open – in her title defence – Kenin then crashed out of the Phillip Island Trophy at the first hurdle.
Kenin rallied to beat Andrea Petkovic first-up in Miami, but the 22-year-old was beaten 6-4 4-6 6-4 by 27th seed Ons Jabeur.
Jabeur and Sara Sorribes Tormo – who shocked 21st seed Elena Rybakina 6-1 3-6 6-2 – will meet for a spot in the quarter-finals.
PLISKOVA FALLS TO PEGULA… AGAIN
For the third time this past month, 2019 Miami Open runner-up Pliskova went down 6-1 4-6 6-4 to 29th seed Pegula.
Australian Open quarter-finalist Pegula conquered Pliskova in Doha and Dubai before repeating the feat in Miami on Sunday.
"I played her a lot the last three weeks, three tournaments," Pegula said. "I kind of expected her to play well there. Even when I was up I still felt like she could easily come back just because she plays so aggressive and she serves well."
After reeling off the final four games, Pegula set up a last-16 showdown with 23rd seed Maria Sakkari, who dismantled qualifier Liudmila Samsonova 6-0 6-1.
World number one Swiatek sees off Xiyu in Madrid opener
World number one Iga Swiatek overcame Wang Xiyu with the minimum of fuss on Thursday to progress to the third round of the Madrid Open.
Swiatek has yet to win the title in Madrid, which is the only clay-court European event at which the Pole has not triumphed, but she got off to a flying start with a 6-1 6-4 victory over Xiyu.
"I love this place. I got to know the city a little better last year," Swiatek said. "So this time I feel more comfortable around."
Next up for the 22-year-old is a third-round tie against 27th seed Sorana Cirstea on Saturday.
Data Debrief
Swiatek has registered 150 match wins on the WTA Tour since the start of 2022. Elena Rybakina and Coco Gauff are the next best with 108 wins each.
She also became the first player born this century to claim 50 combined match wins in Madrid, Rome and Roland-Garros, since the inaugural women's singles event at the Madrid Open in 2009.
Dominant Gauff double bagels Rus at Madrid Open
Coco Gauff made a flying start to her Madrid Open campaign on Thursday, recording the first double bagel main-draw win of her career as she cruised past Arantxa Rus to reach the round of 32.
Gauff needed just 51 minutes to see off 33-year-old Rus as she booked a meeting with Ukraine's Dayana Yamstremska for Saturday.
The US Open champion lost just 18 points throughout the match – eight in the opener and 10 in the second set – as she put any doubts over her recent form to bed in emphatic fashion.
Gauff's power proved too much for Rus in the opener, the third seed winning 88 per cent of points behind her first serve and converting three of four break points to go a set up in just 23 minutes.
Rus brought up four break points midway through the second set, but when she failed to convert them, Gauff punished her in ruthless fashion by reeling off another three games then finishing things with a terrific forehand winner.
Speaking after her win, the American said: "I played really well today. It was just one of those days for me… 6-0 6-0, I've never done that before, I'll probably never do it again."
Data Debrief: Gauff matches Azarenka, Halep feat
Gauff is just the third player to register a 6-0 6-0 win in the women's singles draw at the Madrid Open, following in the footsteps of two former world number ones in Victoria Azarenka and Simona Halep.
The American, who only turned 20 last month, is also the youngest player to double bagel an opponent in any main-draw match on the WTA Tour since Iga Swiatek did so against Karolina Pliskova in the 2021 Italian Open final in Rome.
Nadal cruises past teen Blanch to tee up De Minaur rematch in Madrid
Darwin Blanch presented little challenge for Rafael Nadal, who dropped just one game in a convincing 6-1 6-0 triumph at the Madrid Open.
Nadal is feeling his way back to fitness, but 16-year-old qualifier Blanch offered little resistance to the 22-time major champion on Thursday.
Making his farewell appearance at the Madrid Open, where he has won five titles, Nadal needed just 64 minutes to progress to round two.
"I think today I played against an opponent with a great future in front [of him], but today, still making mistakes," said Nadal.
"I just tried to be there, be solid all the time without taking a lot of risks. It worked well. I'm happy to be through and I wish him all the very best for the future."
Nadal's reward is a rematch with Alex de Minaur, who he lost to last week in Barcelona.
Data Debrief
This game saw the largest age gap (21 years, 117 days) between two opponents in the history of ATP Masters 1000 events.
Nadal has now registered 57 wins at the Madrid Open, which is 20 clear of any other player.
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