Manchester City boss Pep Guardiola is concerned the March international break could result in another wave of coronavirus positives for Premier League clubs.
City can go 10 points clear at the Premier League summit with victory over Everton at Goodison Park on Wednesday - a rearranged fixture after the initially scheduled December encounter was postponed due to a COVID-19 outbreak among Guardiola's squad.
Aston Villa also withdrew from action during the post-Christmas period and Newcastle United were affected similarly earlier in the season.
The Premier League responded by upping testing at clubs to twice a week and, in the most recent period returned, there were two positives from 2,970 players and club staff tested.
This represents a significant drop from 36 positives out of 2,593 tests between January 4-10 but Guardiola is wary of some of this good work being undone when his players and others begin travelling the globe again over the coming weeks.
City's Champions League last-16 trip to Borussia Monchengladbach has been switched to Budapest, with European games featuring Premier League counterparts Liverpool, Manchester United, Arsenal and Chelsea also switched from their original venues due to local COVID-19 protocols.
Asked whether the subsequent international matches next month will place members of his squad at risk, Guardiola replied: "Hopefully not but the only way to be protected from this virus is to stay at home and don’t move and social distance and no contact and don’t travel.
"Now the people are going to travel, the players are going to the national teams and it’s difficult after to control it, so I think something is going to rise unfortunately.
"I would love to say or to guess it's not going to happen but from experience it happened in two or three waves already worldwide, so if you move you take a risk to be contaminated, to get the virus again."
Earlier this month, FIFA granted clubs the right to refuse to release players called up to their national teams if there is a mandatory quarantine period of five days or more on their return.
For Premier League clubs - and significantly for City given the make-up of Guardiola's squad - this means players representing Portugal or South American nations can be held back because anyone returning from those countries will need to quarantine in a hotel for 10 days as they are on the UK's "red list".
Guardiola said there had been no discussions between clubs and federations to his knowledge and does not want the Premier League's handling of the pandemic to be undermined.
"I think the Premier League should be concerned about this, all the leagues [should be] concerned," he said.
"I know the national federations need to play, for the qualification, for the friendly games, for their preparation for the European Championship in summer time, this is normal.
"But the reason why there were a lot of cases in the Premier League and now there is no cases is because people don't move - home and training centre, game, home no more than this.
"The players are going to the national team, they know the situation. We'll tell them to be careful and after they go to the national team they are going to protect them as well."
City will try to extend a record-breaking run of 16 consecutive victories at Goodison Park. They will be without in-form midfielder Ilkay Gundogan (groin), although Kevin De Bruyne (hamstring) will travel with the squad after a month on the sidelines.
After the initial Everton postponement, Guardiola did not envisage City - or any other side - being able to put such a relentless run together.
"That’s true, everyone thought [the season] would be cancelled again," he added.
"Here in England in December and January, the cases rose amazingly but the Premier League and all the clubs, all the team managers and the protocols were so effective."
Coventry City 2-3 Hull City: Tigers win five-goal thriller to keep play-off hopes alive
Hull City kept their hopes of gatecrashing the Championship play-offs alive with a thrilling 3-2 win over beaten FA Cup semi-finalists Coventry City on Wednesday.
Noah Ohio scored the winner with his first touch after coming on as a second-half substitute as Hull moved within three points of sixth-placed Norwich City with two games to play.
Coventry, meanwhile, saw their own hopes of returning to Wembley Stadium for a second successive play-off final all but ended, as they sit six points further back with three matches remaining.
Three days on from their remarkable comeback against Manchester United, the Sky Blues twice fought back to level things at Coventry Building Society Arena. Jaden Philogene's shot squirmed under goalkeeper Bradley Collins to put Hull ahead 31 minutes in, but Kasey Palmer levelled within five minutes with a stunning free-kick.
Hull went back ahead in controversial circumstances on the stroke of half-time, Liverpool loanee Fabio Carvalho converting from the penalty spot despite replays showing Joel Latibeaudiere's foul on Liam Delap took place outside the area.
Mark Robins' men again dragged themselves back into the game as Bobby Thomas headed Jay Dasilva's cross in just before the hour mark, but it was Liam Rosenior's visitors who found a winner.
Thomas went from hero to villain as his poor back pass sold Collins short, and Ohio got a toe to the ball to score the winner, keeping Hull's hopes of Premier League football intact.
Van Dijk: Liverpool have 'no chance' in title race after derby defeat
Virgil van Dijk conceded Liverpool might be out of the Premier League title race after they suffered a surprise 2-0 defeat to Everton in Wednesday's Merseyside derby.
Jarrad Branthwaite and Dominic Calvert-Lewin scored in either half to give the Toffees their first win over Liverpool at Goodison Park since 2010.
Liverpool struggled to find a way through the Toffees' defence despite dominating for long periods, and the Reds' captain says they will not outlast Arsenal and Manchester City without major improvements.
Speaking to Sky Sports, Van Dijk said: "If we play like today, then we have no chance to consider ourselves in the title race.
"We have to just focus on the next game and that will be a tough one anyway, so we will see.
"We're very disappointed, in so many ways. I think everyone has to look at their own performances. Did they really give everything, and do they really want to win the league?
"We're still fighting and there are still games after tonight, but if we play like we did overall in the game today – not winning challenges and giving the referee a chance to give free-kicks like he did many times, then you have no chance to win the title."
Howe: Newcastle performance in Palace defeat 'way off' Spurs win
Eddie Howe admitted Newcastle United's performance in the 2-0 loss at Crystal Palace on Wednesday was "way off" the one that saw them thump Tottenham in their previous game.
Howe's men hammered Spurs 4-0 in their last match, but they never got close to matching the attacking verve from that outing and a Jean-Philippe Mateta double condemned the Magpies to defeat at Selhurst Park.
Newcastle didn't even manage a shot on target until the 87th minute, accumulating just 0.42 xG (expected goals) as the likes of Alexander Isak and Anthony Gordon struggled to make an impact.
Only against Manchester City in August (one) have Newcastle recorded fewer shots on target in a Premier League game this season than their two against Palace, and Howe was critical of his team's display in the loss, one that all but ends their hopes of finishing in the top four.
"[It is a] bad day for us," Howe told Newcastle's club media.
"I thought we were disappointing today, especially in the first 60 minutes. We were way off our levels against Tottenham and our best levels.
"I thought technically we didn't deliver a good performance, and out of possession I don't think it was a particularly good performance either."
Newcastle were unlocked twice for Mateta to score by a Palace side who themselves only generated 0.88 xG.
Howe was left frustrated by the manner in which his side conceded, adding: "I think we'll be disappointed with our performance technically today, and that's probably epitomised by the two goals where we're disappointed with how we've given them the ball in those situations and then how we defended.
"I think the goals sum up aspects of our performance where there was some good, lots of moments that could have led to opportunities, but we were slow to shoot around the box," he said.
The defeat, combined with Manchester United's 4-2 win over Sheffield United, means Newcastle drop to seventh, while eighth-placed West Ham are two points behind with a game in hand.
Newcastle have now lost eight of their last 11 Premier League away games, while they have lost on four occasions in London in the league this term, only doing so more times in a Premier League season in 2000-01 and 2005-06 (both five).
It's been a disappointing season for Howe and his side, especially compared to the heroics of last term when Newcastle finished in the top four, and the Magpies boss knows there's work to be done to get back to those levels.
"It's a day that we have to take our punishment, deal with it, and then try and improve," Howe continued. "It's frustrating because we know we're capable of much better."
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