England confirmed that Lauren James has withdrawn from the squad for their upcoming friendlies against Germany and South Africa.
James was named in Chelsea's starting line-up for their Women's Champions League win over FC Twente, but was replaced by Johanna Rytting Kaneryd after the warm-up after sustaining a calf injury.
Chelsea manager Sonia Bompastor revealed ahead of the Blues' 5-2 victory over Tottenham that the 23-year-old is expected to be out of action for the next five to six weeks.
It serves as a bitter blow to both Chelsea and England, with James having been in fine form since the beginning of last season.
Since the start of the 2023-24 campaign, only Manchester City duo Khadija Shaw (28) and Lauren Hemp (27) have registered more Women's Super League goal involvements than James (17 - level with Alessia Russo).
James' influence on games goes beyond goals and assists in the WSL, with her 36 completed dribbles since the start of last season a total only bettered by Rytting Kaneryd (37) among her team-mates.
However, England manager Sarina Wiegman does not plan on calling up a replacement for James, with the Lionesses boasting several replacements already in their ranks.