Reiss Nelson scored his first goal of the season and Aaron Ramsdale kept a clean sheet on his return as Arsenal beat Brentford 1-0 in the Carabao Cup.
Nelson’s first-half goal, after some dreadful Brentford defending, was enough to send the Gunners through to the fourth round.
Ramsdale was handed a recall after being dropped in favour of David Raya, who joined from Brentford this summer.
Raya had started Arsenal’s previous three games, including Sunday’s north London derby against Tottenham, displacing Ramsdale after 52 consecutive Premier League games.
With Bukayo Saka and Declan Rice injured against Spurs to join Thomas Partey, Gabriel Martinelli, Leandro Trossard and Jurrien Timber on the sidelines, Mikel Arteta made eight changes in total.
The visitors took the lead after only eight minutes thanks to a mistake by the recalled Mathias Jorgensen, whose pass back wrong-footed Ethan Pinnock.
Eddie Nketiah leapt on the error, cutting the ball back for Nelson who stepped past a sliding Nathan Collins before neatly finishing past Mark Flekken.
Brentford were flat for long periods of their home defeat by Everton in the Premier League on Saturday and this was more of the same in the first half.
They would have been two down after half an hour but for the outstretched leg of Flekken which denied Emile Smith Rowe a goal.
The Bees look as though they are starting to miss their striker Ivan Toney, who is still suspended for admitting breaches of gambling rules and is likely to be an Arsenal target when he is available again in January.
But they eventually began to get forward and Vitaly Janelt’s shot was blocked by the diving Takehiro Tomiyasu.
They almost equalised when captain Christian Norgaard beat Kai Havertz in midfield and crossed for Yoane Wissa, whose first-time shot flew just wide.
There was a wobbly moment for Ramsdale when he was almost caught in possession by Wissa, but the ball ran away from the Bees frontman.
But the keeper came up with a fine save midway through the second half, pushing Wissa’s snap-shot against the far post.
Nelson could have had a second when Havertz got clear down the left and played the ball across, but his shot clipped the outside of Flekken’s post.
Flekken saved well from Nketiah at his near post before Ramsdale flung himself to his left to beat away Frank Onyeka’s drive as the Gunners held on.
Frank praises Brentford's pressing, sees no tactical revamp with Toney departure
Thomas Frank heaped praise on Brentford's pressing following their 3-1 victory over Southampton on Saturday.
Bryan Mbeumo scored twice from Brentford's forwards forcing the Southampton backline into errors as the Bees earned their second Premier League win of the season.
This did not go unnoticed by Frank, who believes his side rank as one of the best in the league when it comes to that specific aspect.
He told BBC Sport: "They made errors because we pressed them unbelievably well. I think we are one of the best teams to do the high pressure in the Premier League.
"The players are so committed and that is the reason why we capitalised on errors from Southampton.”
Despite the departure of Ivan Toney to Al-Ahli, Frank does not think their style of play will have to be restructured too much, with both Mbuemo and Yoane Wissa enjoying productive starts to the season in his absence.
Frank said: “Ivan is a fantastic player, I'd love to have him in the team but he has his own journey and is going elsewhere.
"Our style of play hasn't changed. Wissa and Ivan are different players but the style doesn't change.”
Southampton boss Russell Martin was frustrated with his side’s mistakes at crucial moments, believing their performance was far better than the scoreline suggested.
He said to the BBC: “We made two mistakes that we were punished for, which is frustrating and disappointing.
"I saw lots of good things to feel positive about. I feel a lot better this week than I did after the Nottingham Forest game.”
Brentford 3-1 Southampton: Bees begin life after Toney with comfortable win
Brentford began life without Ivan Toney with a comfortable 3-1 victory over Southampton.
Bryan Mbeumo’s brace and a Yoane Wissa goal proved to be the difference between the two sides and condemned the Saints to their third straight loss since promotion back to the Premier League.
With departed striker Toney watching in the stands after his move to Al-Ahli in Saudi Arabia, the hosts proved too strong for Russell Martin’s men. They created the superior chances and capitalised on an error-strewn performance from Southampton’s backline.
Mbeumo opened the scoring on the stroke of half-time before doubling the lead halfway through the second period and Wissa then got on the scoresheet moments later to continue Brentford’s strong start to the campaign. Yukinari Sugawara bagged a consolation in injury time for the Saints.
Brentford sit in fifth place ahead of the first international break, while Southampton are second-bottom of the league table with zero points.
Data debrief: Wissa continues to prove effective at home
Wissa now has five goals and two assists in his last seven matches at the Gtech Community Stadium.
Brentford have recorded consecutive home league wins for the first time since last November, and the first time in their opening home games since August 2018.
Brentford 3-1 Southampton: Bees begin life without Toney with comfortable win
Brentford began life without Ivan Toney with a comfortable 3-1 victory over Southampton.
Bryan Mbeumo’s brace and a Yoane Wissa goal proved to be the difference between the two sides and condemned the Saints to their third straight loss since promotion back to the Premier League.
With departed striker Toney watching in the stands after his move to Al-Ahli in Saudi Arabia, the hosts proved too strong for Russell Martin’s men. They created the superior chances and capitalised on an error-strewn performance from Southampton’s backline.
Mbeumo opened the scoring on the stroke of half-time before doubling the lead halfway through the second period and Wissa then got on the scoresheet moments later to continue Brentford’s strong start to the campaign. Yukinari Sugawara bagged a consolation in injury time for the Saints.
Brentford sit in fifth place ahead of the first international break, while Southampton are second-bottom of the league table with zero points.
Data debrief: Wissa continues to prove effective at home
Wissa now has five goals and two assists in his last seven matches at the Gtech Community Stadium.
Brentford have recorded consecutive home league wins for the first time since last November, and the first time in their opening home games since August 2018.
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