Bruno Fernandes has "a question mark" over his fitness, Erik ten Hag said ahead of Manchester United's Premier League clash with Tottenham.
The midfielder was forced off during United's FA Cup semi-final win over Brighton and Hove Albion on Sunday with an ankle injury and was later pictured in a protective boot.
With Lisandro Martinez and Raphael Varane already sidelined in a blow to United's defence, the loss of Fernandes would hurt Ten Hag's side going forward.
But on the eve of the trip to Spurs, the manager could not confirm whether Fernandes would be available.
But the Dutchman is not ready to reveal whether the midfielder will sit out their crucial encounter with Spurs or if he could yet be available to feature.
"There are some unavailable," he said. "Martinez, Varane. We have to see how Bruno Fernandes is. We don't know yet. He is a question mark.
"It's more often that players [wear the boot], that we protect them. But [the ankle] has to settle down. We all have seen he played the full game [90 minutes before extra time].
"It happened in the first half. [The game is] Thursday, so tomorrow is quick, but we have to see what is possible."
The win on penalties at Wembley was an effective tonic for an ailing United side after they had lost emphatically at Sevilla to crash out of the Europa League three days earlier.
David de Gea and Harry Maguire both committed costly errors leading to goals in that game, but Ten Hag has continued to talk up their character as the pair recover.
"They are resilient," he said. "They are able to do it. It's not easy, but they can do it. You can have a bad setback but show your character to bounce back.
"I am the Manchester United manager. I have to make sure our players are ready tomorrow against a good opponent, good team, good players. I have to focus [and make sure] they have energy."
Now, United will face a Tottenham team reeling from a 6-1 rout at the hands of top-four rivals Newcastle United last time out.
Harry Kane, who has been linked with a move to Old Trafford, scored the only Spurs goal.
"It's quite clear, his impact on the game for Spurs," Ten Hag said of Kane. "We have a plan for that. You have to defend as a team. He's a clever player, he can have a big impact on the game."
Postecoglou hails 'fantastic' youngster Moore after late Vissel Kobe winner
Ange Postecoglou saluted "fantastic" Mikey Moore, after the teenager struck a late winner in Tottenham's J-League World Challenge clash with Vissel Kobe.
The 16-year-old was the hero with his 88th-minute strike sealing a 3-2 victory at the Japan National Stadium in what was Spurs' first match in their preseason tour of the Far East.
Academy graduate Moore became Tottenham's youngest Premier League player when, aged 16 years and 277 days, he made his senior debut against Manchester City in the penultimate game of last season.
And Postecoglou insists the England youth international, who has scored 10 goals in 12 appearances at under-17 level, is deserving of his first-team opportunities.
"Mikey has been fantastic since we brought him in," he told reporters during his post-match press conference. "He's earned his spot on the roster at the moment; he did at the end of last year.
"He got a run with the first team because we could see in training that he was handling himself really well, and that's followed through into pre-season training.
"He's been good in all the games; he probably should have had three tonight, but he did take his goal well by being in the right areas.
"All we can do is keep allowing him to develop. We have to remember that, last year, he had some injuries, and he is only 16.
"I think the future with a lot of our young guys looks pretty promising, but it's our responsibility to make sure they realise their potential and continue to work hard at their game."
Spurs made it three wins from three during preseason, following their 5-1 and 2-0 victories over Hearts and Queens Park Rangers respectively.
"I thought it was a good game," Postecoglou added. "The conditions did make it difficult for both teams, and we've had a hard week of training.
"Credit to the boys. I thought we played some decent football, and they put in as much effort as they humanly could out there.
"You want to provide some sort of entertainment for the supporters who made a great turnout tonight, not just Spurs supporters, but football supporters in general. It's always nice to give back in that way and, overall, I was pleased."
Guardiola 'cannot imagine' Man City's Premier League success without Ederson
Pep Guardiola believes Manchester City's Premier League dominance in recent seasons would not have been possible without Ederson.
The Brazil goalkeeper's future at the Etihad Stadium is uncertain, amid speculation linking him with a move to Saudi Arabia.
Ederson has been an integral figure for City since his arrival from Benfica in 2017, with 112 clean sheets in 250 Premier League appearances under Guardiola, while recording a save percentage of 68.17.
The 30-year-old conceded just 26 goals last season as the Citizens won an unprecedented fourth successive Premier League title - and their sixth since he joined the club.
Ederson's distribution has also been crucial to City's success, notably completing 942 of his 1,097 passes last term (85.87%).
"I wish from the bottom of my heart Eddie will continue with us," Guardiola said. "I would love him to stay.
"I cannot imagine our processes succeeding these last seasons without him. He is an important figure in the locker room."
Ederson could feature for City on Saturday when they continue their pre-season tour of the United States against Paulo Fonseca's Milan at the Yankee Stadium.
Ten Hag targets further transfers as Man Utd prioritise squad depth
Erik ten Hag wants more transfer activity ahead of his third season in charge of Manchester United, saying the Red Devils must work to replicate their rivals' strength in depth.
Ten Hag signed a new contract after overseeing United's FA Cup final victory over Manchester City in May, having previously been expected to depart.
Ahead of their first full season under the Jim Ratcliffe regime, United have spent an estimated £88million to acquire forward Joshua Zirkzee from Bologna and centre-back Leny Yoro from Lille.
But after United suffered more injuries causing a player to miss at least one match (45) than any other Premier League team last term, Ten Hag believes more is required.
"I want the squad as strong as possible," Ten Hag told reporters at a press conference ahead of Saturday's friendly versus Arsenal.
"We already made two very good buys, so when everyone is fit we have a team that can beat everyone.
"But also in squad depth, we have to catch up. We know that because when we had injuries, we were vulnerable, and we have to avoid this.
"First, by picking up fewer injuries. And second, our squad has to be that good in depth.
"Of course, we have the quality, but in the depth we have to catch up even more, because this will be a season that is survival of the fittest.
"We proved we can beat the best team. Not just once, we did it twice. Our challenge is to do it consistently, that's what we have to work for."
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