Youssoufa Moukoko will miss both legs of Borussia Dortmund's Champions League tie against Chelsea after he was ruled out for around six weeks with an ankle injury.
The 18-year-old was replaced by Sebastien Haller in the first half of in-form Dortmund's 2-0 Bundesliga win at Werder Bremen on Saturday.
Moukoko on Monday discovered he suffered a torn syndesmosis ligament and is expected to be sidelined until late next month.
Dortmund sporting director Sebastian Kehl said: "This is tough news for him and for us, especially in the current stretch. We kept our hopes up, but unfortunately he will be out some time."
The teenager will miss the first leg of Dortmund's round of 16 clash with Chelsea on Wednesday and the return fixture at Stamford Bridge on March 7.
A showdown with RB Leipzig is among the Bundesliga matches the Germany international will sit out.
Dortmund boss Edin Terzic will hope Moukoko will be available when his side travel to face leaders Bayern Munich on March 31, with a home game against second-placed Union Berlin to come a week later.
Terzic's men are three points behind Bayern in third place and have won six consecutive games since the season resumed.
Werder Bremen 0-0 Borussia Dortmund: Schlotterbeck sent off as BVB are held
Borussia Dortmund were held to a 0-0 draw at Werder Bremen in the Bundesliga on Saturday.
Defender Nico Schlotterbeck was sent off for Dortmund in the second half and Nuri Sahin’s side ultimately had to settle for a point.
After an underwhelming start to the match, the visitors were more aggressive following the interval, with substitute Karim Adeyemi making an instant impact with an effort from more than 20 yards out. But Bremen goalkeeper Michael Zetterer was in place to deny the forward.
Dortmund were reduced to 10 men in the 73rd minute when centre-back Schlotterbeck received a second yellow card for sliding in on Bremen forward Justin Njinmah.
BVB still pushed for a winner despite their numerical disadvantage, but a solid Bremen defence withstood late pressure to secure a point at home.
Data Debrief: Defences on top
Neither side can claim they were hugely unfortunate not to have scored, with Dortmund’s expected goals (xG) total of 0.61 only coming in marginally ahead of the hosts (0.41).
BVB did have four shots on target, although all four came from the 58th minute onwards with two of them from substitutes in Adeyemi and Donyell Malen, while Bremen only tested Gregor Kobel – who now has two straight clean sheets – on one occasion.
It was Marvin Ducksch who had the hosts’ only shot on target in his 100th Bundesliga appearance, the first six of which came as a Dortmund player.
The result means Bremen end a run of four straight home defeats to Dortmund in Bundesliga play, although they have now gone nine such matches without a victory.
Brentford 3-1 Southampton: Bees begin life after Toney with comfortable win
Brentford began life without Ivan Toney with a comfortable 3-1 victory over Southampton.
Bryan Mbeumo’s brace and a Yoane Wissa goal proved to be the difference between the two sides and condemned the Saints to their third straight loss since promotion back to the Premier League.
With departed striker Toney watching in the stands after his move to Al-Ahli in Saudi Arabia, the hosts proved too strong for Russell Martin’s men. They created the superior chances and capitalised on an error-strewn performance from Southampton’s backline.
Mbeumo opened the scoring on the stroke of half-time before doubling the lead halfway through the second period and Wissa then got on the scoresheet moments later to continue Brentford’s strong start to the campaign. Yukinari Sugawara bagged a consolation in injury time for the Saints.
Brentford sit in fifth place ahead of the first international break, while Southampton are second-bottom of the league table with zero points.
Data debrief: Wissa continues to prove effective at home
Wissa now has five goals and two assists in his last seven matches at the Gtech Community Stadium.
Brentford have recorded consecutive home league wins for the first time since last November, and the first time in their opening home games since August 2018.
Brentford 3-1 Southampton: Bees begin life without Toney with comfortable win
Brentford began life without Ivan Toney with a comfortable 3-1 victory over Southampton.
Bryan Mbeumo’s brace and a Yoane Wissa goal proved to be the difference between the two sides and condemned the Saints to their third straight loss since promotion back to the Premier League.
With departed striker Toney watching in the stands after his move to Al-Ahli in Saudi Arabia, the hosts proved too strong for Russell Martin’s men. They created the superior chances and capitalised on an error-strewn performance from Southampton’s backline.
Mbeumo opened the scoring on the stroke of half-time before doubling the lead halfway through the second period and Wissa then got on the scoresheet moments later to continue Brentford’s strong start to the campaign. Yukinari Sugawara bagged a consolation in injury time for the Saints.
Brentford sit in fifth place ahead of the first international break, while Southampton are second-bottom of the league table with zero points.
Data debrief: Wissa continues to prove effective at home
Wissa now has five goals and two assists in his last seven matches at the Gtech Community Stadium.
Brentford have recorded consecutive home league wins for the first time since last November, and the first time in their opening home games since August 2018.
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