Romelu Lukaku struggled in Inter's first defeat of the season at Lazio, but Simone Inzaghi was more concerned by the Nerazzurri's inability to win without the talismanic forward at his best.
Lukaku has returned on loan to Inter, where he won the 2020-21 Serie A title, after a difficult year with Chelsea.
The forward swiftly appeared to have rediscovered his best form in Italy, scoring two minutes into his second Inter debut against Lecce and then teeing up a Lautaro Martinez goal at home to Spezia.
But Friday's third match of the season at Lazio brought a reality check, with Lukaku scarcely troubling the capital club.
The Belgian attempted three shots – all with his head – but only one hit the target, and he did not create a single chance; his 19 touches were the fewest of any starter on either team.
Lukaku was substituted for Edin Dzeko in the 69th minute with the game level, yet Lazio went on to win 3-1.
"[Lukaku] had played the first two games in the best way," Inzaghi told DAZN when quizzed on the change.
"More than looking at the changes, we have to analyse a lost game, a direct clash that hurts.
"We know that we have to do more in these games to win, beyond the condition of Lukaku or Lautaro."
Martinez had equalised for the Nerazzurri early in the second half, but Inzaghi felt the game turned with a close-range Denzel Dumfries header that was saved just 88 seconds after that goal.
"The defeat stings for the way it happened," the coach explained. "The match was balanced and hard fought against a quality opponent.
"Luis Alberto's goal [Lazio's second] broke the game; at 1-1, we had Dumfries' chance that would have changed things.
"We had to show more nastiness on our side because these games are played in moments."
Lazio 2-2 Milan: Leao salvages draw but Rossoneri still winless
Rafael Leao came off the bench to earn Milan a 2-2 draw with Lazio at the Stadio Olimpico on Saturday, but Paulo Fonseca's side are still without a Serie A win this season.
Milan were in front at the break through Strahinja Pavlovic's eighth-minute goal, the Serbian rising highest to power home a header from Christian Pulisic's corner.
However, Lazio hit back in the second half with Valentin Castellanos and Boulaye Dia scoring in quick succession.
Nuno Tavares' first-time ball into the centre was met by the unmarked Castellanos to level in the 62nd minute, then Dia tapped another Tavares cutback home to put the Biancocelesti ahead four minutes later.
Fonseca reacted by sending on four substitutes, and those changes had a swift impact as three of them combined for the leveller.
Theo Hernandez – who joined Leao in being dropped from the start – picked out Tammy Abraham, and his lay-off allowed Leao to escape Tavares to fire past Ivan Provedel.
The game was preceded by an emotional tribute to the man who led Lazio to their last league title, Sven-Goran Eriksson, who died at the age of 76 on Monday.
A Lazio shirt bearing the Swede's name was displayed on the home bench, while a banner held up by the home fans read: "You brought us to the top of the world... Have a good trip Mr. Sven."
Data Debrief: Milan's slow start continues
New Milan boss Fonseca is already under pressure after overseeing a return of two points from his first three league games at the helm.
It is the first time the Rossoneri have drawn two of their opening three matches in a Serie A season since 2011-12, when they also drew two and lost one,
They went on to finish second that season, just four points adrift of champions Juventus. If a title challenge is to take place this term, rapid improvements are needed.
Napoli 2-1 Parma: Lukaku and Anguissa fire Conte's men to last-gasp win
Romelu Lukaku and Andre-Frank Zambo Anguissa scored in second-half stoppage time as Napoli fought back for a thrilling 2-1 victory over Parma in Serie A.
Newly promoted Parma, who stunned Milan last week, looked set to claim a second surprise win in as many games when Ange-Yoan Bonny won and converted a 19th-minute penalty.
The momentum of the game changed, however, when Parma goalkeeper Zion Suzuki was shown his second yellow card for a foul on David Neres with 15 minutes of the 90 remaining.
With no further substitutions available to the visitors, defender Enrico Del Prato took over in goal and went close to getting his team over the line with a clean sheet intact.
However, new signing Lukaku came off the bench to equalise for Napoli in the second minute of stoppage time, shortly after the Partenopei had seen a penalty overturned following a VAR review.
There was more drama to come at the death as Anguissa headed home in the sixth minute of stoppage time, though Napoli also had to survive one last scare as Pontus Almqvist was denied by Alex Meret at the other end.
Data Debrief: Flying start for Lukaku
Just as Napoli's hopes seemed to be slipping away, up stepped debutant Lukaku to level with a low strike, setting the stage for the most remarkable of comeback victories.
Across the last five Serie A campaigns, Lukaku has 29 goals in 48 home games for Inter, Roma and Napoli. That is the fewest home games required by any player to net over 25 goals in the competition during that span.
Parma, meanwhile, were left to rue the sending-off of Suzuki, who became their first goalkeeper to see red in Serie A since Antonio Mirante against Sassuolo, back in March 2015.
Bayer Leverkusen 2-3 Leipzig: Visitors fightback halts unbeaten streak for Alonso's side
Bayer Leverkusen suffered their first defeat in 36 Bundesliga matches, as Leipzig came from behind to stun Xabi Alonso's side 3-2 at BayArena.
Lois Openda struck twice for Marco Rose's, who recovered from 2-0 down to make it two wins from two and move to the summit of the table.
It looked like business as usual for the reigning Bundesliga champions when they scored twice in the last seven minutes of the first half through Jeremie Frimpong and Alejandro Grimaldo.
However, Leipzig replied deep into first-half stoppage time with Kevin Kampl reducing the deficit.
Openda then brought the visitors level in the 57th minute, before a stunning long-range strike completed the turnaround 10 minutes from time, condemning Leverkusen to their first league defeat in 15 months.
Data Debrief: Leverkusen's long streak comes to a shuddering halt
Leipzig became the first side to beat Leverkusen in a Bundesliga match since Bochum achieved the feat a staggering 462 days earlier.
The visitors have begun a Bundesliga season with two wins from two for only the second time, also doing so in 2019-20.
They are also now unbeaten in 13 league matches, their longest such streak since Rose took charge.
As for Leverkusen, their invincible streak is officially history, as is their 29-game unbeaten run on home soil.
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