Tottenham secured a huge victory in the race for Champions League qualification by winning 3-0 against Arsenal, who played an hour of the north London derby with 10 men.
A win for Arsenal would have been enough for them to clinch a top-four finish in the Premier League for the first time since 2016, but they are now just one point clear of Spurs with two games remaining.
Harry Kane scored the opener from the penalty spot after Cedric Soares' foul on Son Heung-min and it was a coming together with the South Korean that resulted in Rob Holding being shown a second yellow card in the 33rd minute.
Kane doubled his tally before half-time and Son put the result beyond doubt early in the second period, putting Antonio Conte's men firmly in contention for a Champions League spot.
Tottenham were awarded a penalty in the 22nd minute when Cedric shoved Son over in the box and Kane showed great composure to send his spot-kick into the bottom-right corner.
Holding was given his marching orders after catching Son in the head with his arm and Spurs doubled their advantage just four minutes later.
Son's corner was helped on towards the back post by Rodrigo Bentancur, with Kane stooping to nod into the back of the net from close range.
Things got worse for Arsenal just two minutes after the restart, with Son dinking the ball home through a crowd of bodies after Gabriel Magalhaes' tackle on Kane.
Aaron Ramsdale made two saves in quick succession to deny Emerson Royal and Kane, while Son was unable to turn Ryan Sessegnon's pass on target despite being one-on-one with the keeper.
Gabriel hobbled off late on with a hamstring injury for the Gunners, who were left to mull over a defeat that put a dent in their hopes of a return to the Champions League.
What does it mean? Gunners see red
Arsenal were completely undone after Holding's dismissal, which was their 13th red card in the Premier League since Mikel Arteta's first game in charge in December 2019 – that is five more than any other team in the same timeframe.
They were unable to keep things tight and consequently fell to a third straight away loss to Spurs in the league for the first time since August 1961.
The Gunners must regroup ahead of a trip to Newcastle United and a clash with Everton, with Spurs still to face Burnley and Norwich City.
Another Kane-ing for Arsenal
With his first-half double, Kane took his haul of top-flight goals against Arsenal to 13. The only team he has scored more against in the competition are Leicester City (17). Kane has now been involved in 52 goals in 69 London derby appearances in the Premier League, two behind Thierry Henry's record.
No Holding on for Gunners
While they still had their full complement, Arsenal had a chance of getting back into the game at 1-0 down. However, Holding managed to commit four fouls – the most he has made in a single Premier League appearance – in the opening 33 minutes and his red card ruined their hopes.
What's next?
Spurs entertain Burnley on Sunday, meaning Arsenal could be outside the top four when they play away at Newcastle United on Monday
Slot: Guardiola contract is 'good news' for Premier League
Arne Slot believes it is "good news" for the Premier League that Pep Guardiola has signed a contract extension with Manchester City.
The Spaniard signed a two-year extension with the reigning champions and will remain in the dugout at the Etihad until 2027.
He has won 18 major trophies in his time at City, including six Premier League titles, and twice beat Jurgen Klopp's Liverpool to the top-flight crown by a single point.
Guardiola averages 2.35 points per game in the Premier League, the highest rate of any manager (20+ matches). Indeed, he is so far ahead of the next highest (Alex Ferguson's 2.16), he could lose his next 26 league games in a row and would still be top.
Slot is yet to face City since taking over from Klopp at the start of the season, with the rivals' first meeting of the season set for December 1.
"It's good news for City and for the league because everyone wants the best managers and the best players over here," Slot said when asked about Guardiola's new contract.
"He is definitely one of the best managers, maybe the best manager of the league.
"He's won four titles in a row, so it's fair to say he's maybe the best manager in the league.
"On the other hand, they have so many quality players that, if he would have made the choice to leave, I wouldn't have expected them to end up bottom of the league next season."
Other Premier League managers echoed Slot's sentiment, with Brighton boss Fabian Hurzeler, who inflicted a fourth consecutive defeat on City before the international break, saying it is the "best thing that can happen to the Premier League".
"He is one of the best coaches in the world," Hurzeler said. "With his ideas, he always brings something new to the football stage, and it is always a challenge to compete against him.
"He always adapts quickly, always has new ideas and he can always win the game. I'm very happy because we can learn from him and to compete with him is a big, big experience."
Newcastle United boss Eddie Howe added: "He's contributed so much to English football. He's revolutionised how a lot of teams play.
"I think he's incredibly talented, and it's good for the English game that he's still here.
"He will continue to develop and evolve his style, and people will potentially continue to follow that. From the competition side, I think it keeps the Premier League as the best in the world."
Vlahovic out of Juventus clash with Milan
Dusan Vlahovic will miss Juventus' trip to Milan in Serie A this weekend and is also a doubt for the Champions League game at Aston Villa, head coach Thiago Motta has confirmed.
Vlahovic returned from the international break with a muscle problem in his left thigh, and the manager, after he confirmed the Serbian's absence for Saturday's game at San Siro, was asked about his chances of playing on Wednesday at Villa Park.
"I don't know. He definitely won't be there tomorrow. We hope to have him back as soon as possible," Motta told a press conference on Friday.
"Injuries are part of football. Now it's Vlahovic's turn, but we'll keep playing with the same principles, attacking and defending together."
Vlahovic is the latest of Motta's injury problems at Juventus. Argentine winger Nicolas Gonzalez missed the last six league games and is still unavailable, while Poland striker Arkadiusz Milik is a long-term absentee.
Brazilian midfielder Douglas Luiz will also miss the game with Milan and defender Juan Cabal recently suffered an Anterior Cruciate Ligament (ACL) injury, the same issue which will keep fellow defender Gleison Bremer out for the rest of the season.
"I'm really disappointed for Cabal because, like Bremer, he'll be out for a long time," Motta said.
"This is another reason to push ourselves, to commit that bit more so that these absences don't weigh too heavily."
Juventus go into the game as the only unbeaten side in Serie A but find themselves sixth in the standings in what is so far a very tight title race, with just two points separating Motta's side from leaders Napoli.
"It's very balanced and this is good for both us and the public," Motta said.
"We must all try to continue like this. We have to try to get as many positive results as possible."
Milan are one place behind Juve but six points off Motta's side.
Vlahovic out of Juventus clash with AC Milan
Dusan Vlahovic will miss Juventus' trip to AC Milan in Serie A this weekend and is also a doubt for the Champions League game at Aston Villa, head coach Thiago Motta has confirmed.
Vlahovic returned from the international break with a muscle problem in his left thigh, and the manager, after he confirmed the Serbian's absence for Saturday's game at San Siro, was asked about his chances of playing on Wednesday at Villa Park.
"I don't know. He definitely won't be there tomorrow. We hope to have him back as soon as possible," Motta told a press conference on Friday.
"Injuries are part of football. Now it's Vlahovic's turn, but we'll keep playing with the same principles, attacking and defending together."
Vlahovic is the latest of Motta's injury problems at Juventus. Argentine winger Nicolas Gonzalez missed the last six league games and is still unavailable, while Poland striker Arkadiusz Milik is a long-term absentee.
Brazilian midfielder Douglas Luiz will also miss the game with Milan and defender Juan Cabal recently suffered an Anterior Cruciate Ligament (ACL) injury, the same issue which will keep fellow defender Gleison Bremer out for the rest of the season.
"I'm really disappointed for Cabal because, like Bremer, he'll be out for a long time," Motta said.
"This is another reason to push ourselves, to commit that bit more so that these absences don't weigh too heavily."
Juventus go into the game as the only unbeaten side in Serie A, but find themselves sixth in the standings in what is so far a very tight title race, with just two points separating Motta's side from leaders Napoli.
"It's very balanced and this is good for both us and the public," Motta said.
"We must all try to continue like this. We have to try to get as many positive results as possible."
Milan are one place behind Juve but six points off Motta's side.
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