Manchester City edged closer to the Premier League title, while there was significant change at the bottom of the table on Sunday.
City were eliminated from the Champions League semi-finals in dramatic fashion by Real Madrid in midweek, but saw their domestic hopes boosted when Liverpool dropped points against Tottenham on Saturday.
Pep Guardiola's side subsequently breezed past Newcastle United to move three points clear of the Reds with three games remaining, while West Ham hit relegated Norwich City for four.
Elsewhere, Arsenal continued their charge for Champions League qualification with a narrow victory over 10-man Leeds United, who ended the day in the relegation zone after Everton triumphed at Leicester City.
Here, Stats Perform takes a look at the pick of the Opta data from the day's top-flight fixtures.
Manchester City 5-0 Newcastle United: Sterling provides as title charge continues
Raheem Sterling was at the double as City strengthened their grasp on top spot with a 5-0 rout of Newcastle at the Etihad Stadium.
Sterling and Aymeric Laporte struck in the first half, with Joao Cancelo teeing up the England international's opener as the full-back became the fourth of Guardiola's players to reach 10 assists in all competitions this season (also Kevin de Bruyne with 13, Phil Foden and Gabriel Jesus - both 11).
City are the only team in Europe's big five leagues to have four or more different players reach 10 assists in all competitions this campaign, and Guardiola's men furthered their advantage after the interval.
Rodri then scored following a corner, as Laporte did in the first half, as City managed their 19th and 20th goals from set-piece situations this term in the league, excluding penalties. They have conceded just once from set-pieces themselves, with their plus-19 differential the best figure recorded in a single season in the Premier League since such records are available (2006-07 onwards).
Foden added a fourth before Sterling capped a fine victory with his 51st Premier League goal at the Etihad, becoming only the second player to pass 50 strikes for City at home in the competition after Sergio Aguero (106).
City have beaten Newcastle 28 times in the Premier League (D8 L8), more than they have any other side in the competition. In their league history, they have only beaten Everton (72 times) more often than the Magpies (68 times).
Meanwhile, Eddie Howe has lost all 12 of his Premier League meetings with City – 10 of those against Guardiola – the worst 100 per cent losing record a manager has against a single opponent or against another boss in the competition.
Arsenal 2-1 Leeds United: Ill-tempered Whites fall into relegation zone
An Eddie Nketiah double kept Arsenal on course for Champions League qualification as they triumphed 2-1 against 10-man Leeds, who dropped into the bottom three for the first time since October 30.
Nketiah fired the Gunners into a 2-0 lead as he became just the second Arsenal player to score twice in the opening 10 minutes of a Premier League game after Kanu (versus Sunderland in October 2002).
With Alexandre Lacazette out of favour, Nketiah has stepped up as Mikel Arteta's talisman, scoring four goals in his last four league games – just one fewer than he had managed in his first 52 top-flight appearances.
Luke Ayling was then dismissed for a mindless two-footed lunge on Gabriel Martinelli after 27 minutes, Leeds' earliest red card in the competition since April 1998 (when Lucas Radebe saw red after 17 minutes against Everton).
Tempers continued to flare before the interval as Leeds picked up their 95th and 96th yellow cards of the season, setting a new record for the most bookings for a club within a single Premier League campaign.
Diego Llorente offered Jesse Marsch's visitors brief hope as he poked home with Leeds' first shot on target, which marked the first home league goal Arsenal have conceded from a corner since February 2021 (also against Leeds).
However, Arsenal held on for victory to move four points clear of fifth-placed Tottenham, who they face on Thursday knowing victory will secure Champions League football next campaign.
Leicester City 1-2 Everton: Toffees move out of bottom three
Mason Holgate's second-half header proved the difference as Everton climbed out of the relegation zone with a battling 2-1 victory at Leicester.
Before this game, Leicester had won eight of their last nine top-flight matches against sides starting the day inside the relegation zone (D1), but the Foxes were caught cold by Vitalii Mykolenko's early volley.
That made Mykolenko the first Ukrainian to score a Premier League goal for Everton, the 39th different nationality to find the net in the competition for the Toffees, the sixth most of all clubs.
Patson Daka restored parity five minutes later, with all five of the striker's Premier League goals coming at the King Power Stadium – only Jamie Vardy (6) has netted more often at home for the club in the top-flight in 2021-22.
Holgate delivered the decisive finish in the 30th minute with his second league goal in his last five matches, one more than he had managed across his previous 109 top-flight appearances beforehand (one).
Brendan Rodgers will be left frustrated by the nature of Holgate's goal, given it was the 15th Premier League strike Leicester have conceded from a corner this campaign – the most by a side in a single campaign since Brighton and Hove Albion in 2017-18 (16).
Victory marked the first away league win in 15 games for Everton, ending a seven-game losing streak on the road as Frank Lampard's side moved a point clear of Leeds and Burnley having played one game fewer.
Norwich City 0-4 West Ham: Bowen and Benrahma on song to down Canaries
Said Benrahma scored twice as West Ham responded to Thursday's Europa League semi-final heartbreak by cruising past relegated Norwich 4-0 at Carrow Road.
Benrahma struck after 12 minutes before Michail Antonio ended his joint-longest goal drought in the top-flight with his fifth Premier League strike against the Canaries, only against Tottenham (six) has he scored more in the competition.
Algeria international Benrahma doubled his tally before the interval, taking him to 21 direct goal contributions in the competition (nine goals, 12 assists). Since his debut in 2020, Jarrod Bowen (30) and Antonio (28) are the only other Hammers to register 20+ top-flight goal involvements.
Bowen assisted both of Benrahma's strikes as the former Hull City man became just the second player for West Ham to register at least 10 goals and 10 assists in a Premier League season, and the first since Paolo Di Canio in 1999-00 (16 goals, 13 assists).
Indeed, only Harry Kane (32) has been involved in more goals among English Premier League players in all competitions than Bowen this season (27 – 16 goals, 11 assists).
Manuel Lanzini's second-half penalty rounded off the victory as West Ham won a Premier League away game by at least a four-goal margin for just the third time, while it was the first time the Hammers have put at least four goals past a side in consecutive league visits since doing so against Tottenham in November 1966.
Meanwhile, Norwich have failed to score in 20 different league games this season, becoming the first side to do so in at least 20 matches in three different Premier League campaigns (also in 1994-95 and 2019-20).
Van Dijk: Liverpool have 'no chance' in title race after derby defeat
Virgil van Dijk conceded Liverpool might be out of the Premier League title race after they suffered a surprise 2-0 defeat to Everton in Wednesday's Merseyside derby.
Jarrad Branthwaite and Dominic Calvert-Lewin scored in either half to give the Toffees their first win over Liverpool at Goodison Park since 2010.
Liverpool struggled to find a way through the Toffees' defence despite dominating for long periods, and the Reds' captain says they will not outlast Arsenal and Manchester City without major improvements.
Speaking to Sky Sports, Van Dijk said: "If we play like today, then we have no chance to consider ourselves in the title race.
"We have to just focus on the next game and that will be a tough one anyway, so we will see.
"We're very disappointed, in so many ways. I think everyone has to look at their own performances. Did they really give everything, and do they really want to win the league?
"We're still fighting and there are still games after tonight, but if we play like we did overall in the game today – not winning challenges and giving the referee a chance to give free-kicks like he did many times, then you have no chance to win the title."
Howe: Newcastle performance in Palace defeat 'way off' Spurs win
Eddie Howe admitted Newcastle United's performance in the 2-0 loss at Crystal Palace on Wednesday was "way off" the one that saw them thump Tottenham in their previous game.
Howe's men hammered Spurs 4-0 in their last match, but they never got close to matching the attacking verve from that outing and a Jean-Philippe Mateta double condemned the Magpies to defeat at Selhurst Park.
Newcastle didn't even manage a shot on target until the 87th minute, accumulating just 0.42 xG (expected goals) as the likes of Alexander Isak and Anthony Gordon struggled to make an impact.
Only against Manchester City in August (one) have Newcastle recorded fewer shots on target in a Premier League game this season than their two against Palace, and Howe was critical of his team's display in the loss, one that all but ends their hopes of finishing in the top four.
"[It is a] bad day for us," Howe told Newcastle's club media.
"I thought we were disappointing today, especially in the first 60 minutes. We were way off our levels against Tottenham and our best levels.
"I thought technically we didn't deliver a good performance, and out of possession I don't think it was a particularly good performance either."
Newcastle were unlocked twice for Mateta to score by a Palace side who themselves only generated 0.88 xG.
Howe was left frustrated by the manner in which his side conceded, adding: "I think we'll be disappointed with our performance technically today, and that's probably epitomised by the two goals where we're disappointed with how we've given them the ball in those situations and then how we defended.
"I think the goals sum up aspects of our performance where there was some good, lots of moments that could have led to opportunities, but we were slow to shoot around the box," he said.
The defeat, combined with Manchester United's 4-2 win over Sheffield United, means Newcastle drop to seventh, while eighth-placed West Ham are two points behind with a game in hand.
Newcastle have now lost eight of their last 11 Premier League away games, while they have lost on four occasions in London in the league this term, only doing so more times in a Premier League season in 2000-01 and 2005-06 (both five).
It's been a disappointing season for Howe and his side, especially compared to the heroics of last term when Newcastle finished in the top four, and the Magpies boss knows there's work to be done to get back to those levels.
"It's a day that we have to take our punishment, deal with it, and then try and improve," Howe continued. "It's frustrating because we know we're capable of much better."
Dyche challenges Everton to 'go and do it again' after crucial derby victory
Sean Dyche challenged his Everton players to "go and do it again" after his team defeated Liverpool at Goodison Park in the Merseyside derby.
Everton won 2-0 on Wednesday, clinching a home victory over their local rivals for the first time since 2010 thanks to goals from Jarrad Branthwaite and Dominic Calvert-Lewin.
While it also dented Liverpool's title hopes, the victory presented a huge step forward in Everton's hopes of staying up.
They are now eight points clear of the relegation zone, with four games left to play, and the possibility of points to come back should they successfully appeal the second of their points deductions for financial breaches.
Dyche, though, insisted the job is not done as he looks towards another big game on Saturday, when Brentford visit Goodison Park.
"Very pleased with the reaction," Dyche told Sky Sports.
"This was a different game with the organisation and the belief in the organisation. They're a good side, we know that. The commitment from us had to be there. The energy of the side and also the key moments.
"We spoke about the desire and the energy of the team and the physical side of the game. The lads did it on Sunday and they'll have to do it again. That's the challenge.
"We stayed focused tonight and I asked if they could stay with us and they did. Sunday was massive and now it was a massively important derby game. For people like Seamus Coleman, he wears his heart on his sleeve and he's so happy.
"We should be on 41 points and the story's different. Three clean sheets in three home games. The challenge for the players is to go and do it again."
Calvert-Lewin led the line brilliantly, converting Everton's second with a towering header early in the second half. He has scored three goals in his last four Premier League games for the Toffees, as many as in his previous 28 appearances in the competition.
"I thought [Calvert-Lewin] was outstanding tonight," Dyche said.
"We've been trying to get him back to where he needs to be and I thought he was outstanding. He gets a goal. He tried to get it over the line and I love that. The second one is a great header. No, I thought he was outstanding tonight.
"Jordan Pickford made some big saves in the first half. It's rare you stop these sides having chances so you need moments yourself. It's hard to pick out one or two [players]."
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