Eintracht Frankfurt clinched a place in the Europa League final and ended West Ham's dream run as Rafael Borre netted in a 1-0 win over the 10-man visitors.
David Moyes' team had Aaron Cresswell sent off for preventing a clear goalscoring chance early on, before Borre put Oliver Glasner's hosts in front with a neat finish after 26 minutes.
West Ham struggled to create clear-cut chances despite putting in a spirited performance, as their strong European run came to a disappointing end with a 3-1 aggregate defeat.
Despite sitting 11th in the Bundesliga, Frankfurt could end the campaign by securing a major European trophy and a spot in next season's Champions League by winning the May 18 final in Seville.
After a scrappy start, West Ham were dealt a huge blow when Cresswell hauled Jens Hauge down on the edge of the area 18 minutes in, with the VAR advising referee Jesus Manzano to send off the left-back before Filip Kostic drove the resulting free-kick wide.
The hosts needed less than 10 minutes to make their numerical advantage count, as Borre swept a side-footed finish into the bottom-left corner after meeting Ansgar Knauff's cut-back.
The Hammers struggled to assert themselves in a boisterous atmosphere, but almost found a surprise equaliser when Evan Ndicka cleared off the line after Jarrod Bowen's free-kick struck Kurt Zouma at the back post.
Borre hit a left-footed volley into Alphonse Areola's arms immediately after the break, before Craig Dawson headed Michail Antonio's cross straight at Kevin Trapp after an hour.
Moyes was sent off for a touchline outburst as West Ham's European dream slipped away, before Tomas Soucek missed a glaring headed chance in the final minute as the hosts cruised into the final.
What does it mean? Frankfurt build on first-leg triumph for historic semi-final win
Frankfurt's victory saw them reach their first European final since the 1980 UEFA Cup, when they beat Borussia Monchengladbach on away goals after a two-legged 3-3 aggregate draw.
With the win, Glasner's men have also become the first German team to reach finals in both the Europa League and UEFA Cup.
Hammers left deflated after Cresswell red
West Ham's hopes of reaching their first major European final since the 1975-76 Cup Winners' Cup were dealt a monumental blow when Cresswell became the first English player to ever receive two red cards in a single season in a European competition.
Cresswell was also sent off against Lyon in the last round, and is the first English player to be shown red in a European semi-final since Chelsea's John Terry in 2012 (against Barcelona in the Champions League).
Borre continues continental run
As well as recording seven goals and four assists in the Bundesliga this season, Borre has been in inspired form in Frankfurt's Europa League knockout games.
His composed finish means he has either scored (two) or assisted (one) three of Frankfurt's last five Europa League goals.
What's next?
Frankfurt host Borussia Monchengladbach in the Bundesliga on Sunday, while West Ham must turn their attentions back to securing European football for next season when they travel to Norwich City in the Premier League on the same day.
Hurtig the hero after late goal sends Arsenal into Champions League quarters
Lina Hurtig's 89th minute winner ensured Arsenal progressed to the quarter-finals of the Women's Champions League after edging Juventus 1-0 on Thursday.
After being frustrated for large parts of the encounter, Hurtig bundled home from close range after Martina Lenzini's poor clearance to book the Gunners' place in the last eight.
Despite Arsenal dominating the early exchanges, it was Juventus who had the first sight of goal, though Eva Schatzer's effort was easy for Daphne van Domselaar to gather.
In a first half that saw just two shots on target, both coming from the visitors, Renee Slegers' substitutes proved to be the difference for Arsenal.
Slegers introduced Beth Mead, Stina Blackstenius and Hurtig late on, with the latter somehow putting Kim Little's cross over the bar from five yards out.
However, the Swede would atone for her earlier error, combining with fellow substitute Blackstenius to net against her former club and send them out of the competition with two group games remaining.
Meanwhile, in Group D, Barcelona edged closer to the quarter-finals of the competition with a convincing 4-1 victory over St. Polten at the Generali Arena.
The reigning champions are still three points behind Manchester City following their 2-1 win over Hammarby, and know a win against the Swedes next month will see them progress.
Kika Nazareth opened the scoring in the 20th minute after capitalising on a mistake by Kamila Dubcova, notching her second nine minutes later from close range.
Barca found themselves three goals up at the break when Vicky Lopez netted her first goal in the competition to put the result beyond doubt.
There was also a landmark moment for Alexia Putellas, who netted her 200th goal for the club with a well-taken effort into the far corner.
Valentina Madl took some of the shine off an otherwise impressive display from the visitors, who have now taken their tally to 20 goals from their four matches in the competition.
Guardiola agrees two-year contract extension with Man City
Pep Guardiola will be Manchester City manager for at least two more seasons after 2024-25, after he signed a two-year contract extension on Thursday.
The 53-year-old was coming to the end of his City deal, which was due to expire at the end of the current campaign, but he has opted to remain at the Etihad Stadium.
The deal itself will take Guardiola's tenure at the club to over a decade, making him City's longest-serving manager since Les McDowall in 1963.
There had been suggestions that he may leave at the end of the season following the announcement that director of football Txiki Begiristain was on his way out.
Guardiola was strongly linked with the England job after Gareth Southgate resigned in the wake of their Euro 2024 final defeat, but the Football Association appointed Thomas Tuchel last month.
“Manchester City means so much to me," Guardiola said. “This is my ninth season here; we have experienced so many amazing times together. I have a really special feeling for this football club.
“That is why I am so happy to be staying for another two more seasons.
“Thank you to everyone for continuing to trust and support me – The Owner, The Chairman Khaldoon, Ferran, Txiki, the players and, of course, the fans… everyone connected to Manchester City. It has always been an honour, a pleasure and a privilege to be here.
“I have said this many times before, but I have everything a manager could ever wish for, and I appreciate that so much.
“Hopefully, now we can add more trophies to the ones we have already won. That will be my focus.”
Having been appointed in 2016, Guardiola is by some distance Manchester City's most successful manager of all time, having won 18 major trophies during his time at the club.
That list includes their first-ever Champions League triumph in 2023 and six Premier League titles, including an unprecedented four on the spin.
He also boasts a 72.04% win percentage across all competitions, which is unsurprisingly the highest of any full-time City manager in history.
Shaw at the double as Man City progress in Champions League
Khadija Shaw scored twice as Manchester City beat Hammarby 2-1 to seal their place in the Women's Champions League quarter-finals.
Gareth Taylor's team entered Thursday's game with a perfect record in Group D, and their fourth win in as many European matches ensured they finished in the top two.
Shaw—the leading scorer in the Women's Super League this season with eight goals—put them ahead in the 31st minute, driving into the area after taking in Yui Hasegawa's pass before seeing her shot deflect into the top corner.
Shaw was booked for celebrating in front of the home fans despite appearing to have objects thrown at her from the stands, and Hammarby should have levelled when Julia Blakstad fired wide 10 minutes later.
The hosts did draw level three minutes into the second half as Ellen Wangerheim tapped home while City's Laura Blindkilde Brown was down appealing for a free-kick.
That parity was short-lived, though, as Shaw blasted into the top corner from 25 yards out, taking her overall tally for this season to 12 goals in all competitions.
In Group C, meanwhile, Bayern Munich lost their perfect record as they played out a 1-1 draw with Valerenga, boosting Arsenal's hopes of topping the pile.
Jovana Damnjanovic came off the bench to put Bayern ahead 15 minutes from time in Norway, but Elise Thorsnes headed home following an 88th-minute corner to snatch a point for the hosts.
Arsenal could now move within a point of Bayern when they face Juventus in Group C's other match later on Thursday.
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