If the battle for supremacy in your fantasy leagues is anything like as tight as the Premier League title race, there is no room for error.
That might encourage some managers to play it safe and stick with what they know, but the very best know how rewarding a risk can be.
So, should you wish to gamble and shuffle the pack, why not be guided by Stats Perform's Opta-powered picks?
Four players for the coming matchweek are highlighted below for your consideration...
MARTIN DUBRAVKA (Norwich City v Newcastle United)
It is probably safe to assume that at least until the turn of the year, few fantasy managers were relying on a Newcastle goalkeeper. Not only did the Magpies give three different keepers a run between the posts, but they conceded a Premier League record 80 goals in the calendar year of 2021.
However, it is all change in 2022. In fact, only Alisson (nine) and Ederson (seven) have kept more clean sheets than Dubravka (five) this year, with the Newcastle man now on six for the season.
He has conceded 13 goals over this spell (12 excluding own goals), but five of those came in a single match at Tottenham – and it is tough to imagine struggling Norwich similarly picking apart a now resolute Newcastle defence.
ALEX TELLES (Arsenal v Manchester United)
There may be plenty of movement of United players out of XIs this week, with none of those involved in Tuesday's 4-0 defeat at Liverpool emerging with any credit. However, Telles played no part from the bench.
Given how hapless that new-look United back line looked, it is hard to see how Telles will not come into the side four days later – and he has earned his place both in Rangnick's team and your fantasy selections.
No United player can better the left-back's three assists in 2022, with only Bruno Fernandes (35) and Jadon Sancho (21) creating more than his 13 chances.
MASON MOUNT (Chelsea v West Ham)
Chelsea will also be looking to make amends in a big game after their own shocking midweek defeat, but Mount at least continued his fine form against Arsenal, adding an assist after scoring two and creating another in his previous league outing at Southampton.
The England midfielder now has 10 goals and nine assists in the top flight this term, meaning he could soon become the first Chelsea player to reach double-figures in both categories since Eden Hazard in 2018-19 (16 goals and 15 assists). He would also be the youngest Blues man to achieve the feat at 23, with Juan Mata 24 in 2012-13 (10 goals and 10 assists).
Whether Mount gets the assist to reach that mark this weekend or not, only Mohamed Salah (34), Son Heung-min (23) and Harry Kane (20) have more than his 19 goal involvements this season, so expect him to plunder fantasy points one way or another.
IVAN TONEY (Brentford v Tottenham)
Tottenham may head into the weekend in fourth, but few will confidently back against Brentford. Spurs have lost their past five away London derbies, while only Chelsea have won more points in clashes between capital clubs this season than the Bees (14).
And if Brentford are to add to landmark victories over Arsenal and Chelsea with another against Tottenham, Toney is highly likely to have a key role to play, having scored eight goals and created another two in 2022.
Only Son (nine) – an opponent on Saturday – has netted more in this calendar year, although Kane (15) beats both for goal involvements.
'Legend' Van Nistelrooy departs Man Utd after Amorim arrival
Manchester United have confirmed Ruud van Nistelrooy has departed the club following Ruben Amorim's arrival at Old Trafford.
Van Nistelrooy returned to the club in July on a two-year contract as an assistant to Erik ten Hag.
He was placed in interim charge after Erik ten Hag's dismissal last month.
The 48-year-old oversaw four games during his temporary tenure, earning victories over Leicester City in the EFL Cup and PAOK in the Europa League. United were then held to a 1-1 draw by Chelsea, but Van Nistelrooy signed off in style with a 3-0 win over the Foxes in the Premier League on Sunday.
But Amorim, who began his new role on Monday, has decided against retaining the Dutchman's services, with the club saying the full men's first team coaching composition will be announced in due course.
"Ruud is and always will be a Manchester United legend," the club said in a statement.
"We are grateful for his contribution and the way in which he approached his role throughout his time with the club. He will always be very welcome at Old Trafford."
Assistant Rene Hake, goalkeeping coach Jelle ten Rouwelaar and analyst Pieter Morel have also left the club.
However, former United midfielder Darren Fletcher will remain in his coaching role and continue his link between the first team and the academy.
Pereira replaces Amorim as Sporting head coach
Sporting CP have confirmed Joao Pereira as the club's new head coach following Ruben Amorim's departure to Manchester United.
Pereira, who made 154 appearances across three different spells with Sporting, has put pen to paper on a deal that runs through until 2027 with the Primeira Liga champions.
The 40-year-old also appeared five times under Amorim during the 2020-21 season, a campaign that saw Sporting claim their first top-flight title in 19 years.
Pereira has previously managed Sporting's Under-23 side, taking charge of 53 games and winning 20 of those (D17 L16), averaging 1.45 points per match.
He most recently took charge of Sporting's B team, but oversaw just 11 matches, and he is relishing the opportunity of leading the club after the international break.
"As a player, Sporting gave me a lot, allowing me to play for the national team, join one of the best leagues in the world and return home twice," Pereira said.
"I only repaid them with a Super Cup and a national championship, which felt more like their gift to me.
"That’s something I regret, so as a coach I’d like to repay them with more titles because Sporting deserve it.
"If I had doubts and thought things might go wrong, I wouldn’t be here. It hasn’t even crossed my mind that it could go poorly.
"I know we’ll face challenges, but I believe it will go well."
But Pereira has a tough act to follow, with Amorim ending his glittering stint with the club on a high after a 4-2 win over Braga on Sunday.
Amorim won 164 of his 231 games in charge of Sporting, averaging a win percentage of 71%, which is a club record.
During his time in charge, only Manchester City (127) won more matches than his Sporting team (122) across Europe's top 10 leagues.
"Ruben leaves behind a legacy, and that legacy isn’t only in titles, victories, and records but also in the unity he built among the Sporting family," Pereira added.
"I know this brings great responsibility, but that responsibility comes hand-in-hand with a strong ambition and motivation to continue making Sporting a winning club with a bright future.”
Pereira's first assignment will come in the Taca de Portugal against fourth-tier side Amarante on November 22, before welcoming Arsenal to the Estadio Jose Alvalade in the Champions League five days later.
'I'm not naive', says Amorim as he relishes 'difficult' Man Utd challenge
Ruben Amorim insisted he was "not naive" about the "difficult" task awaiting him as Manchester United's new head coach.
Amorim took charge of his final game as Sporting CP's manager on Sunday, culminating in a 4-2 away win against Braga to maintain their perfect start to the Primeira Liga season.
The 39-year-old ended his glittering career with the Portuguese side having won 164 of his 231 games at the helm (D34 L33), bowing out with a win percentage of 71%, a club record.
Amorim arrives at Old Trafford after a string of impressive results under interim boss Ruud van Nistelrooy, who went unbeaten across his four games during his temporary stint.
Though the Portuguese's arrival at the club and the positive results of late have lifted the mood in Manchester, Amorim acknowledged the enormity of the task at hand.
"I feel ready for the new challenge," Amorim told reporters after his final match at Sporting. "I'm not naive, I know it's going to be very different, very difficult.
"I'm at peace now. I can focus on my new job, and I'm looking forward to starting tomorrow.
"I know it will be difficult to reproduce what I have here anywhere else, but there are other places with different exposure and pressure."
United are yet to confirm the precise nature of Amorim's backroom team and whether Van Nistelrooy will remain at Old Trafford.
The Dutchman returned to Old Trafford in July as an assistant coach under former boss Erik ten Hag, signing a two-year contract.
"I have to talk with him [on Monday]," Amorim added. "I will explain everything. I'm very clear, and I will tell you like it is. So let's wait."
Amorim now has 13 days during the international break to prepare for his match in charge, which comes at Portman Road against Ipswich Town on November 24.
His first Old Trafford outing comes four days later in the Europa League against Norwegian champions Bodo/Glimt.
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