Thomas Tuchel says it will be "almost impossible" for Chelsea to avoid a Champions League exit but they must dream of fighting back to knock Real Madrid out.
A Karim Benzema consigned the holders to a 3-1 defeat in the first leg of the quarter-final tie at Stamford Bridge last week.
Chelsea responded to that loss by hammering Southampton 6-0 in the Premier League on Saturday, while Madrid stayed on course to be crowned LaLiga champions with a 2-0 victory over Getafe.
The Blues, who will be without injured record signing Romelu Lukaku due to an Achilles injury, have a mountain to climb at Santiago Bernabeu on Tuesday and Tuchel is realistic over their chances of progressing to the last four.
But the German expects his side to put up more of a fight than they did in London last week.
He said: "It's one of the biggest challenges to perform as an away team at the Bernabeu. If you have to win by at least two goals, it is very difficult, almost impossible. We need to overperform.
He added: "We never manage our input and effort by chances we have for a result, we never did and will not start tomorrow by giving less because it's very unlikely we will make it.
"It's unlikely, but we will try, we will play to our full limit. It's a big night and a big match and we wll try to be in better shape and in a better condition than in the first leg."
Tuchel says Chelsea must arrive in the Spanish capital with belief they can pull off a stunning comeback.
"We need nothing else than a fantastic script," he said. "The task is incredibly high after the first leg. You're always allowed to dream and sometimes it is important to imagine and dream about things, but it doesn't change the fact we need to be ready to deliver.
"We will try hard, it's worth trying. Hopefully we can fulfil our dream, but realistically we have to invest a lot."
Cesar Azpilicueta is available after testing negative for COVID-19, while Callum Hudson-Odoi remains sidelined with an Achilles injury and Ross Barkley is out due to illness.
Maguire's league season over as Man Utd confirm muscle injury
Manchester United defender Harry Maguire has suffered a muscle injury that will see him miss the final games of the Premier League season.
United face Crystal Palace on Monday, before rounding off their Premier League campaign with some tough fixtures against title-chasing Arsenal, fellow European hopefuls Newcastle United and then Brighton.
However, Erik ten Hag will have to do without centre-back Maguire, with the England international set to miss around three weeks with a muscular problem, further compounding United's injury issues in defence.
That time frame also casts Maguire's participation in the FA Cup final, which takes place on May 25, into doubt.
United will take on holders and rivals Manchester City in the Wembley showpiece, which is a repeat of last season's final.
England manager Gareth Southgate will be hoping the defender recovers fully in time for Euro 2024.
Pochettino hails Chelsea's growth after thumping West Ham
Mauricio Pochettino is delighted by Chelsea's progress in recent weeks following their dominant 5-0 victory over West Ham at Stamford Bridge.
Nicolas Jackson scored twice, while Cole Palmer, Conor Gallagher and Noni Madueke were also on target as the Blues leapfrogged Manchester United into seventh place with three games remaining.
Pochettino's side, who made it back-to-back wins in the space of three days following their 2-0 success over Tottenham on Thursday, are finishing the season strongly, having now lost just one of their last 12 matches.
The Blues came under scrutiny during their 6-0 rout of Everton last month, when Jackson and Madueke were involved in an altercation following a disagreement over who should take a penalty, with the responsibility eventually going to regular taker Palmer.
However, three weeks on, the pair combined to positive effect with Madueke unselfishly squaring the ball for Jackson to tap in the first of his two goals, despite being one-on-one with West Ham keeper Alphonse Areola.
And Pochettino believes that action epitomises the growth his side are demonstrating as the season draws towards a conclusion.
"[We are] so pleased, so happy. The players deserve big credit, to play again after a few days and to play again at this level," he said, as reported by Football London.
"We received criticism for the situation with the penalty against Everton, but a young team needs to make mistakes to improve.
"It was a great action from Noni [squaring the ball for Jackson's first goal] to see how the group is starting to believe. It is always a process that takes time. It can take one month, six months or one year.
"People who know about football know the process of building a team is the most difficult thing. You need to have the capacity to emphasise with every single player.
"They need to trust in us, in the coaching staff. That is the most important thing, and then you need to start to identify what the players need. This process always takes time."
Discussing Chelsea's hopes of qualifying for Europe, Pochettino said: "From the beginning of the season, I said we should win because we are Chelsea.
"We need to be mature, keep the momentum and look to improve every single game. We are trying to be in Europe; it will be good for the team and the players to be in Europe this season."
Ronaldo delivers another hat-trick as Al Nassr ease past Al Wedha
Cristiano Ronaldo crafted a decisive hat-trick as Al Nassr hammered Al Wedha 6-0 in Saturday's Saudi Pro League meeting.
Portugal veteran Ronaldo found the net twice in the first 12 minutes at Al Awal Park before completing his treble after the interval.
Sadio Mane teed up Ronaldo's third finish, as well as an 18th-minute strike from Otavio, who returned the favour for the Senegal international to score on the stroke of half-time.
Mohammed Al Fatil added a late sixth as Al Nassr recorded their seventh straight league win since their March 7 loss against Al Raed, moving them back within nine points of leaders Al Hilal.
Jorge Jesus's Al Hilal swept Al Tauwoon aside in a 3-0 away triumph on Friday for their fourth straight victory across all competitions.
Talisman Aleksandar Mitrovic opened the scoring at King Abdullah Sport City Stadium before Saud Abdulhamid and Saleh Alsherhi wrapped up a win that kept Al Hilal in charge of the title race.
There was no such fortune for fifth-placed Al Ittihad as they fell to a third straight defeat in all competitions after a 3-1 loss away against Abha.
Jota levelled after Grzegorz Krychowiak's 57th-minute penalty, only for Hassan Al-Ali and Fabian Noguera to power hosts Abha to a comfortable win.
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