Thomas Tuchel says it will be "almost impossible" for Chelsea to avoid a Champions League exit but they must dream of fighting back to knock Real Madrid out.
A Karim Benzema consigned the holders to a 3-1 defeat in the first leg of the quarter-final tie at Stamford Bridge last week.
Chelsea responded to that loss by hammering Southampton 6-0 in the Premier League on Saturday, while Madrid stayed on course to be crowned LaLiga champions with a 2-0 victory over Getafe.
The Blues, who will be without injured record signing Romelu Lukaku due to an Achilles injury, have a mountain to climb at Santiago Bernabeu on Tuesday and Tuchel is realistic over their chances of progressing to the last four.
But the German expects his side to put up more of a fight than they did in London last week.
He said: "It's one of the biggest challenges to perform as an away team at the Bernabeu. If you have to win by at least two goals, it is very difficult, almost impossible. We need to overperform.
He added: "We never manage our input and effort by chances we have for a result, we never did and will not start tomorrow by giving less because it's very unlikely we will make it.
"It's unlikely, but we will try, we will play to our full limit. It's a big night and a big match and we wll try to be in better shape and in a better condition than in the first leg."
Tuchel says Chelsea must arrive in the Spanish capital with belief they can pull off a stunning comeback.
"We need nothing else than a fantastic script," he said. "The task is incredibly high after the first leg. You're always allowed to dream and sometimes it is important to imagine and dream about things, but it doesn't change the fact we need to be ready to deliver.
"We will try hard, it's worth trying. Hopefully we can fulfil our dream, but realistically we have to invest a lot."
Cesar Azpilicueta is available after testing negative for COVID-19, while Callum Hudson-Odoi remains sidelined with an Achilles injury and Ross Barkley is out due to illness.
Slot: Guardiola contract is 'good news' for Premier League
Arne Slot believes it is "good news" for the Premier League that Pep Guardiola has signed a contract extension with Manchester City.
The Spaniard signed a two-year extension with the reigning champions and will remain in the dugout at the Etihad until 2027.
He has won 18 major trophies in his time at City, including six Premier League titles, and twice beat Jurgen Klopp's Liverpool to the top-flight crown by a single point.
Guardiola averages 2.35 points per game in the Premier League, the highest rate of any manager (20+ matches). Indeed, he is so far ahead of the next highest (Alex Ferguson's 2.16), he could lose his next 26 league games in a row and would still be top.
Slot is yet to face City since taking over from Klopp at the start of the season, with the rivals' first meeting of the season set for December 1.
"It's good news for City and for the league because everyone wants the best managers and the best players over here," Slot said when asked about Guardiola's new contract.
"He is definitely one of the best managers, maybe the best manager of the league.
"He's won four titles in a row, so it's fair to say he's maybe the best manager in the league.
"On the other hand, they have so many quality players that, if he would have made the choice to leave, I wouldn't have expected them to end up bottom of the league next season."
Other Premier League managers echoed Slot's sentiment, with Brighton boss Fabian Hurzeler, who inflicted a fourth consecutive defeat on City before the international break, saying it is the "best thing that can happen to the Premier League".
"He is one of the best coaches in the world," Hurzeler said. "With his ideas, he always brings something new to the football stage, and it is always a challenge to compete against him.
"He always adapts quickly, always has new ideas and he can always win the game. I'm very happy because we can learn from him and to compete with him is a big, big experience."
Newcastle United boss Eddie Howe added: "He's contributed so much to English football. He's revolutionised how a lot of teams play.
"I think he's incredibly talented, and it's good for the English game that he's still here.
"He will continue to develop and evolve his style, and people will potentially continue to follow that. From the competition side, I think it keeps the Premier League as the best in the world."
Vlahovic out of Juventus clash with Milan
Dusan Vlahovic will miss Juventus' trip to Milan in Serie A this weekend and is also a doubt for the Champions League game at Aston Villa, head coach Thiago Motta has confirmed.
Vlahovic returned from the international break with a muscle problem in his left thigh, and the manager, after he confirmed the Serbian's absence for Saturday's game at San Siro, was asked about his chances of playing on Wednesday at Villa Park.
"I don't know. He definitely won't be there tomorrow. We hope to have him back as soon as possible," Motta told a press conference on Friday.
"Injuries are part of football. Now it's Vlahovic's turn, but we'll keep playing with the same principles, attacking and defending together."
Vlahovic is the latest of Motta's injury problems at Juventus. Argentine winger Nicolas Gonzalez missed the last six league games and is still unavailable, while Poland striker Arkadiusz Milik is a long-term absentee.
Brazilian midfielder Douglas Luiz will also miss the game with Milan and defender Juan Cabal recently suffered an Anterior Cruciate Ligament (ACL) injury, the same issue which will keep fellow defender Gleison Bremer out for the rest of the season.
"I'm really disappointed for Cabal because, like Bremer, he'll be out for a long time," Motta said.
"This is another reason to push ourselves, to commit that bit more so that these absences don't weigh too heavily."
Juventus go into the game as the only unbeaten side in Serie A but find themselves sixth in the standings in what is so far a very tight title race, with just two points separating Motta's side from leaders Napoli.
"It's very balanced and this is good for both us and the public," Motta said.
"We must all try to continue like this. We have to try to get as many positive results as possible."
Milan are one place behind Juve but six points off Motta's side.
Vlahovic out of Juventus clash with AC Milan
Dusan Vlahovic will miss Juventus' trip to AC Milan in Serie A this weekend and is also a doubt for the Champions League game at Aston Villa, head coach Thiago Motta has confirmed.
Vlahovic returned from the international break with a muscle problem in his left thigh, and the manager, after he confirmed the Serbian's absence for Saturday's game at San Siro, was asked about his chances of playing on Wednesday at Villa Park.
"I don't know. He definitely won't be there tomorrow. We hope to have him back as soon as possible," Motta told a press conference on Friday.
"Injuries are part of football. Now it's Vlahovic's turn, but we'll keep playing with the same principles, attacking and defending together."
Vlahovic is the latest of Motta's injury problems at Juventus. Argentine winger Nicolas Gonzalez missed the last six league games and is still unavailable, while Poland striker Arkadiusz Milik is a long-term absentee.
Brazilian midfielder Douglas Luiz will also miss the game with Milan and defender Juan Cabal recently suffered an Anterior Cruciate Ligament (ACL) injury, the same issue which will keep fellow defender Gleison Bremer out for the rest of the season.
"I'm really disappointed for Cabal because, like Bremer, he'll be out for a long time," Motta said.
"This is another reason to push ourselves, to commit that bit more so that these absences don't weigh too heavily."
Juventus go into the game as the only unbeaten side in Serie A, but find themselves sixth in the standings in what is so far a very tight title race, with just two points separating Motta's side from leaders Napoli.
"It's very balanced and this is good for both us and the public," Motta said.
"We must all try to continue like this. We have to try to get as many positive results as possible."
Milan are one place behind Juve but six points off Motta's side.
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