Will it be Mohamed Salah or Sadio Mane? Italy or Portugal – or indeed neither? Can Canada end their long wait, and are the United States and Australia at risk of missing out?
Those questions and plenty more are set to be answered over the next week or so as World Cup qualifying concludes for many nations.
Just 15 of the 32 participants have so far been confirmed for Qatar 2022, leaving 48 teams battling for the 17 remaining spots.
Fourteen more countries will be assured of a finals berth come the end of next week in what is very much crunch time for those still in contention.
Stats Perform looks at the key talking points.
Egypt seeking revenge in AFCON final repeat
Less than two months on from meeting in the Africa Cup of Nations final, Egypt and Senegal face off over two legs for a place in Qatar.
Senegal prevailed in a penalty shoot-out to claim their first AFCON crown and, buoyed by that triumph, will consider themselves as favourites here.
While both teams boast an array of top-class talent, this fixture is being billed as a showdown between Liverpool team-mates Salah and Mane.
The two biggest stars in African football, only one of the pair will be part of the World Cup later this year – and neither will fancy watching it all unfold from home.
This is not the only grudge match taking place in the CAF section over the next week and a half, as fierce rivals Ghana and Nigeria will also face off in a two-legged play-off.
Cameroon are up against Algeria, Mali take on Tunisia and DR Congo meet Morocco in the other three ties, each of which will be concluded on March 29.
European heavyweights on collision course
Since the play-off draw in the UEFA section took place in November, all talk has centered around a potential meeting between Italy and Portugal for a place in the finals.
The winners of the past two European Championships, either the Azzurri or the Selecao will miss out on the biggest tournament of them all.
It should never have been this way, of course, as both teams were strong favourites to finish top of their groups and qualify automatically.
Italy finished second to Switzerland and Portugal were runners-up to Serbia, meaning the sides must now come through two qualifying ties.
First up for the reigning European champions is a meeting with North Macedonia in Palermo, while Portugal face Turkey in Porto, with the winners of both ties advancing.
Should, as expected, Italy and Portugal come through those semi-finals, the latter will have the advantage of staging the final on home soil five days later.
For Portugal skipper Cristiano Ronaldo, it presents what will surely be his last chance to play at a record-equalling fifth World Cup.
Pathways impacted by political events
Path C of UEFA qualifying is undoubtedly the most eye-catching, but there are also some tasty fixtures in the other two sections – not least a possible Home Nations derby.
Scotland and Wales were kept apart in the Path B semi-finals but could meet in the final should they overcome Ukraine and Austria respectively.
However, due to ongoing events in Ukraine, their game against Scotland has been pushed back – likely until June – as has the final involving either Wales or Austria.
In Path C, Russia had been due to face Poland, but the invasion of Ukraine forced FIFA and UEFA's hand and they have been banned from competing.
Poland have therefore been handed a bye to the qualifying play-off final, where either Sweden or the Czech Republic await. That match will be contested next week as planned.
Canada on verge of ending long wait, USA with work to do
The United States qualified for every World Cup between 1990 and 2014, but they missed out on a place at Russia 2018 after an embarrassing loss to Trinidad and Tobago.
Gregg Berhalter's side are by no means assured of one of the three automatic qualification spots in the CONCACAF section this time around, either.
USA sit second with three games to go, but they still have to travel to third-placed Mexico, as well as facing Panama and Costa Rica, who occupy fourth and fifth respectively.
Level on points with Mexico and four ahead of Costa Rica, it could be a tense finale to qualifying for the Stars and Stripes.
That should not be the case for Canada, who are eight points clear of fourth and are all but assured of ending their 36-year wait to make a second World Cup finals appearance.
Brazil and Argentina through, but who will join them?
The drawn-out South American qualifiers are nearing their conclusion and only four of the 10 sides know their fate at this juncture.
It has been plain sailing for Brazil and Argentina, who are assured of an automatic qualifying spot with three games to go, including a rescheduled meeting between the pair.
Behind those perennial World Cup representatives are Ecuador, who have been the surprise package in qualifying and can finish no lower than fifth.
Ecuador will not be content with anything other than a top-four finish, though, and they can make certain of that with victory over Paraguay.
Assuming Ecuador get over the line, that will leave Uruguay, Peru, Chile, Colombia and Bolivia battling it out for progression, which sets up some intriguing fixtures.
Uruguay occupy fourth place, meaning their qualifying aspirations are in their own hands, but they have Peru and Chile – the two sides behind them – still to face.
Socceroos sweating on finals spot
Only four teams advance automatically from the CONMEBOL section, with the team in fifth entering a play-off against the winner of the AFC fourth round in a one-off tie in June.
That may well turn out to be Australia as the Socceroos are five and four points behind top two Saudi Arabia and Japan in Group B with two games to go.
However, those remaining two fixtures are against those nations occupying automatic qualification places, so Australia may yet sneak through.
Iran and South Korea have already made certain of progression in Group A, meanwhile, leaving the United Arab Emirates, Lebanon and Iraq to compete for third place.
The two third-placed finishers – which, as it stands, are Australia and the UAE – will meet in a one-legged match ahead of that aforementioned play-off with a CONMEBOL side.
Ramos in 'final phase' of recovery, says PSG boss Luis Enrique
Luis Enrique confirmed that Paris Saint-Germain striker Goncalo Ramos is nearing a return to action after sustaining an ankle injury on the opening day of the season.
Ramos, who scored 14 goals in 40 appearances in all competitions in his debut season for PSG last year, has not featured for the Parisiens since their 4-1 win over Le Havre in August.
But despite his absence, Luis Enrique's side sit top of the Ligue 1 standings ahead of welcoming Toulouse to the Parc des Princes this Friday.
They are also the top scorers in the division, netting 33 goals in 11 matches so far, nine more than Marseille, who are second in the scoring table.
And as the hectic festive schedule kickstarts, Luis Enrique revealed Ramos has already returned to full first-team training.
"It was the 25th and that is in a few days, so it is the final phase of his recovery," Luis Enrique told reporters.
"As for when he is available (to play) we do not know. We will see in training, he is doing really well and is in full training."
Following Friday's fixture against Toulouse, PSG travel to the Allianz Arena to face Bayern Munich in the Champions League, hoping to ignite their European campaign.
The Ligue 1 champions are at risk of failing to qualify for the knockout stages of the competition having taken four points from their first four games this season.
They currently sit 25th in the new 36-team league table, and with an important week coming up, Luis Enrique insisted he would think about rotating his squad.
"You mustn't only think about the game against Toulouse but also the workload for players with their national teams," he said.
"So we will make decisions based on what we think. We want to win against Toulouse, which is our main target."
Ousmane Dembele did not feature during the international break after he left the France training camp with a hamstring issue, though he is expected to feature this Friday.
"In theory, it was nothing serious. I don't think it was a big issue and these things happen during the season," Luis Enrique said.
"It is normal with such a busy schedule, he should be available to play."
While Toulouse sit 10th in the league standings, they will provide PSG with a difficult test. They come into the game on the back of three consecutive wins, all without conceding a goal.
PSG have also not won any of their last two meetings against Toulouse (D1 L1), and could go three games without a win against the Violets for the second time in the 21st century after a winless streak between December 2007 to October 2009 (five).
Hurzeler: Brighton need to 'work to get momentum' despite Man City win
Brighton and Hove Albion boss Fabian Hurzeler believes his players need to rebuild their momentum following a two-week break after their 2-1 victory over Manchester City.
The Seagulls came back from a goal down in dramatic fashion to inflict City's fourth successive defeat in all competitions last time out.
Though the international break came at a bad time for his in-form team, Hurzeler refused to criticise the schedule ahead of their trip to the Vitality Stadium.
"You always have to work to get momentum. It's always a new game and no matter if there's a break between games or not, the game starts from zero," he told a pre-match press conference.
"You have to go into the game and do the things you can influence to the maximum.
"You can't say 'we won against Manchester City and now the momentum will keep going', it's about fighting for momentum.
"It's a new game, a different challenge and a really big challenge because Bournemouth are one of the strongest teams at the moment."
Bournemouth have also beaten City recently, with the Cherries also triumphing over Arsenal and Southampton in their last three home matches.
"They can play very intense, they run a lot, they have individual quality, they are in good shape. For me at the moment, they're one of the best teams in the league," Hurzeler said of the Cherries.
Bournemouth manager Andoni Iraola, meanwhile, was keen to stress that his players need to keep their concentration against Brighton. The Cherries were beaten 3-2 away to Brentford last time out, despite having taken the lead twice.
“You never want to lose the last game before the break because at the end you remember the last feeling. We will remember this week, the actions here against Brentford," he said.
"We can prepare very well for the game against Brighton, that is going to be also very demanding.”
PLAYERS TO WATCH
Bournemouth – Evanilson
Evanilson has scored four goals for Bournemouth since joining the club in August. He is tied with Antoine Semenyo as the club's top scorer, although his goals have come in one fewer appearance.
The Brazilian forward has found the net in three successive matches and will become the first Bournemouth player since Callum Wilson in 2019 to score in four straight top-flight games should he do so on Saturday.
Brighton – Danny Welbeck
Danny Welbeck is Brighton's leading scorer so far this season, with six league goals – a total that includes three opening goals.
He has scored two away goals so far in the current campaign, coming on the opening day at Everton and the only goal of the game at Newcastle United last month.
MATCH PREDICTION: DRAW
Bournemouth come into this in 12th place in the Premier League on 15 points after 11 matches, having lost 3-2 to Brentford in their most recent game.
At home, though, they have taken 10 points from five matches (three wins, one draw, one loss) and come into this with three successive victories at the Vitality Stadium. They have never won four Premier League home games in a row.
Brighton have earned seven points from five away games (two wins, one draw and two losses) and, despite being six places above their hosts in the table, there are just four points between them.
While Bournemouth have won four of their five Premier League home games against Brighton, Fabian Hurzeler's side come into this in good form having won three of their last five (one draw, one loss) Premier League matches – as many victories as they managed across their previous 16 league games (six draws, seven defeats).
OPTA WIN PROBABILITY
Bournemouth – 41.2%
Draw – 25.1%
Brighton – 33.7%
McKenna fired up for 'biggest game in world football' against Man United
Kieran McKenna believes Ipswich Town's Premier League clash with Manchester United will be the "biggest game in world football" this weekend.
United are in action under new manager Ruben Amorim for the first time since the Portuguese officially replaced Arne Slot as head coach.
While plenty of focus is on the visitors at Portman Road, Ipswich are fired up after beating Tottenham 2-1 before the international break.
That was Ipswich's first league win of the season – and their first in the Premier League in 22 years – and now attention turns to facing United.
McKenna, who previously coached United, said at a fan event this week: "Sunday, what a game. It's one we're really, really looking forward to.
"Not for the personal connection, but as manager of Ipswich Town, to be on that stage, it's what we've worked so hard for.
"It's the biggest game in world football anywhere this weekend, the biggest game in the world in the biggest sport in the world and it's at Portman Road."
Ipswich's surprise win at Tottenham last time out moved them up to 17th, while United are 13th after beating Leicester City 3-0 in Ruud van Nistelrooy's final game in caretaker charge.
Amorim took his first training session on Monday, albeit with many first-team stars away on international duty, and the former Sporting CP boss believes his style of play will be clear to see from the off.
"I think you will see an idea," he told the club's website. "You could like it or not, I don't know, but you will see an idea.
"You will see a positioning. You will see something that we want to reach that kind of level. You will feel that.
"We have to know it's [only] two trainings before the first match. This is the best league in the world. But if I have to say something to you, [it's that] you will see an idea. This I can guarantee."
PLAYERS TO WATCH
Ipswich Town - Liam Delap
Delap scored what proved to be Ipswich's winner against Tottenham and has now netted six of his side's 12 Premier League goals this term.
That makes the Manchester City academy product one of only three players to have scored at least half of his side's goals in the competition this season, along with Erling Haaland at City (55%) and Chris Wood at Nottingham Forest (53%).
Manchester United - Alejandro Garnacho
Garnacho was among the scorers against Leicester two weeks ago and has now been directly involved in 20 Premier League goals for United (13 goals and seven assists).
The Argentina international is one of only two non-British players to reach that figure for United before turning 21, along with Cristiano Ronaldo (25 goals).
MATCH PREDICTION: MANCHESTER UNITED WIN
Ipswich are seeking back-to-back Premier League wins for the first time since February 2022, with that run also beginning with a 2-1 victory against Tottenham.
The Tractor Boys are the only side in the competition without a home win this season. Only five newly promoted clubs have failed to win any of their first six home matches, all of whom went back down.
United have won 17 of their past 19 Premier League games against newly promoted opponents, meanwhile, including nine wins in a row in away fixtures.
The Red Devils were 1-0 winners on their most recent league trip to Portman Road in April 2022, but only once have they won successive league games away to Ipswich.
However, the Tractor Boys have lost four of their past five league matches against Man United, failing to score in each of those losses.
OPTA WIN PROBABILITY
Ipswich Town - 22.2%
Draw - 23%
Manchester United - 54.8%
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