Will it be Mohamed Salah or Sadio Mane? Italy or Portugal – or indeed neither? Can Canada end their long wait, and are the United States and Australia at risk of missing out?
Those questions and plenty more are set to be answered over the next week or so as World Cup qualifying concludes for many nations.
Just 15 of the 32 participants have so far been confirmed for Qatar 2022, leaving 48 teams battling for the 17 remaining spots.
Fourteen more countries will be assured of a finals berth come the end of next week in what is very much crunch time for those still in contention.
Stats Perform looks at the key talking points.
Egypt seeking revenge in AFCON final repeat
Less than two months on from meeting in the Africa Cup of Nations final, Egypt and Senegal face off over two legs for a place in Qatar.
Senegal prevailed in a penalty shoot-out to claim their first AFCON crown and, buoyed by that triumph, will consider themselves as favourites here.
While both teams boast an array of top-class talent, this fixture is being billed as a showdown between Liverpool team-mates Salah and Mane.
The two biggest stars in African football, only one of the pair will be part of the World Cup later this year – and neither will fancy watching it all unfold from home.
This is not the only grudge match taking place in the CAF section over the next week and a half, as fierce rivals Ghana and Nigeria will also face off in a two-legged play-off.
Cameroon are up against Algeria, Mali take on Tunisia and DR Congo meet Morocco in the other three ties, each of which will be concluded on March 29.
European heavyweights on collision course
Since the play-off draw in the UEFA section took place in November, all talk has centered around a potential meeting between Italy and Portugal for a place in the finals.
The winners of the past two European Championships, either the Azzurri or the Selecao will miss out on the biggest tournament of them all.
It should never have been this way, of course, as both teams were strong favourites to finish top of their groups and qualify automatically.
Italy finished second to Switzerland and Portugal were runners-up to Serbia, meaning the sides must now come through two qualifying ties.
First up for the reigning European champions is a meeting with North Macedonia in Palermo, while Portugal face Turkey in Porto, with the winners of both ties advancing.
Should, as expected, Italy and Portugal come through those semi-finals, the latter will have the advantage of staging the final on home soil five days later.
For Portugal skipper Cristiano Ronaldo, it presents what will surely be his last chance to play at a record-equalling fifth World Cup.
Pathways impacted by political events
Path C of UEFA qualifying is undoubtedly the most eye-catching, but there are also some tasty fixtures in the other two sections – not least a possible Home Nations derby.
Scotland and Wales were kept apart in the Path B semi-finals but could meet in the final should they overcome Ukraine and Austria respectively.
However, due to ongoing events in Ukraine, their game against Scotland has been pushed back – likely until June – as has the final involving either Wales or Austria.
In Path C, Russia had been due to face Poland, but the invasion of Ukraine forced FIFA and UEFA's hand and they have been banned from competing.
Poland have therefore been handed a bye to the qualifying play-off final, where either Sweden or the Czech Republic await. That match will be contested next week as planned.
Canada on verge of ending long wait, USA with work to do
The United States qualified for every World Cup between 1990 and 2014, but they missed out on a place at Russia 2018 after an embarrassing loss to Trinidad and Tobago.
Gregg Berhalter's side are by no means assured of one of the three automatic qualification spots in the CONCACAF section this time around, either.
USA sit second with three games to go, but they still have to travel to third-placed Mexico, as well as facing Panama and Costa Rica, who occupy fourth and fifth respectively.
Level on points with Mexico and four ahead of Costa Rica, it could be a tense finale to qualifying for the Stars and Stripes.
That should not be the case for Canada, who are eight points clear of fourth and are all but assured of ending their 36-year wait to make a second World Cup finals appearance.
Brazil and Argentina through, but who will join them?
The drawn-out South American qualifiers are nearing their conclusion and only four of the 10 sides know their fate at this juncture.
It has been plain sailing for Brazil and Argentina, who are assured of an automatic qualifying spot with three games to go, including a rescheduled meeting between the pair.
Behind those perennial World Cup representatives are Ecuador, who have been the surprise package in qualifying and can finish no lower than fifth.
Ecuador will not be content with anything other than a top-four finish, though, and they can make certain of that with victory over Paraguay.
Assuming Ecuador get over the line, that will leave Uruguay, Peru, Chile, Colombia and Bolivia battling it out for progression, which sets up some intriguing fixtures.
Uruguay occupy fourth place, meaning their qualifying aspirations are in their own hands, but they have Peru and Chile – the two sides behind them – still to face.
Socceroos sweating on finals spot
Only four teams advance automatically from the CONMEBOL section, with the team in fifth entering a play-off against the winner of the AFC fourth round in a one-off tie in June.
That may well turn out to be Australia as the Socceroos are five and four points behind top two Saudi Arabia and Japan in Group B with two games to go.
However, those remaining two fixtures are against those nations occupying automatic qualification places, so Australia may yet sneak through.
Iran and South Korea have already made certain of progression in Group A, meanwhile, leaving the United Arab Emirates, Lebanon and Iraq to compete for third place.
The two third-placed finishers – which, as it stands, are Australia and the UAE – will meet in a one-legged match ahead of that aforementioned play-off with a CONMEBOL side.
Philadelphia Union v Real Salt Lake: Curtin keen to maintain tough reputation
Jim Curtin is keen to see the Philadelphia Union retain their reputation as a tough team to play against, with his side still unbeaten this season ahead of Saturday's visit of Real Salt Lake.
The Union sit sixth in the Eastern Conference standings with three wins and four draws so far this term, their latest stalemate coming by a 2-2 scoreline against Atlanta United last time out.
While Curtin was somewhat disappointed to see the Union's three-match winning streak ended in Georgia, he is pleased by the resilience they have shown ahead of their return to Subaru Park.
"Whether people in the public think we're good or think we're bad, they will at least say we're tough to play against," Curtin said.
"I think that unequivocally across the board, there's not a coach or general manager or fan in this league that would say we're an easy team to deal with and play against.
"Part of that is not losing, finding ways to turn losses into ties, ties into wins, and we'll look to try to continue to do that and really protect our home field."
Philadelphia face a tough test this weekend, though, against a Salt Lake team currently flying high in third in the Western Conference.
Pablo Mastroeni's men are unbeaten in their last four games, producing their best performance of 2024 to date last time out as they thrashed the Chicago Fire 4-0 on the road.
"I'm so excited about what we can do as a group, as players and coaches, and the onus is on us to continue to get better and really push this thing forward," Mastroeni said after that win.
"I think we've established a decent standard, and we know where we are at our best and where we are lacking, but it's testament to the work the guys are doing during the week."
PLAYERS TO WATCH
Philadelphia Union – Mikael Uhre
Uhre scored the Union's first goal as they fought back from two goals down to draw in Atlanta.
He has four goal involvements in MLS play this term (three goals, one assist), a tally only matched by Daniel Gazdag and Julian Carranza among his Union team-mates.
Real Salt Lake – Cristian Arango
Arango scored twice against the Fire last week and has now been involved in at least one goal in four straight regular-season road games, equalling the longest such streak in Real Salt Lake's history.
Might he break new ground at Subaru Park?
MATCH PREDICTION – PHILADELPHIA UNION WIN
The Union's only win in 12 all-time meetings with Real Salt Lake was a 4-1 home victory when the teams last met at Subaru Park in May 2018 (six draws, five losses). This will be the sides' first meeting on any ground since June 2019.
While the visitors are unbeaten in their last five matches (three wins, two draws), this could be their toughest test to date.
Philadelphia have only lost one of their last 41 regular-season home matches (28 wins, 12 draws), including going unbeaten through their last 16 (nine wins, seven draws), a run dating back over a year.
OPTA WIN PROBABILITY
Philadelphia Union – 57.8%
Real Salt Lake – 17.3%
Draw – 24.9%
New York City v Charlotte FC: Cushing wants more from in-form hosts
Nick Cushing is pushing for more as New York City bid for a third successive victory against Charlotte FC at Yankee Stadium on Saturday.
NYCFC are eighth in the Eastern Conference standings after back-to-back 2-0 home wins over the New England Revolution and D.C. United, having gone four unbeaten (two wins, two draws).
Their consecutive wins have come after a run of just two victories in their previous 10 (three draws, five losses), but Cushing does not want his team to stop there.
"I think the three-game run is something that we have a huge desire to achieve," Cushing said.
"I said after the game in the locker room, it has been a long time since we've gone back-to-back. It's been too long, really, since we went back-to-back, so it's good to enjoy that after the game.
"Now we have the opportunity to do a three-game run. We have to make sure we do that before we think about anything else."
Charlotte have gone the opposite way in recent weeks, losing two of their last three games to leave them behind New York on goal difference.
Former Aston Villa boss Dean Smith acknowledges they need to show more in the forward areas after averaging just one goal per game in 2024.
"That's certainly an area where we need to be better, I think we all know that. We've been working on it for the last three or four weeks," Smith said.
"I think defensively we've been really solid. In terms of our creativity, we've had some big chances that we haven't taken.
"Last week [in a 3-0 loss to Minnesota United] there were some moments we didn't take as well, technically we just failed on that."
PLAYERS TO WATCH
New York City – Santiago Rodriguez
Rodriguez recorded a goal and an assist in NYCFC's win over D.C. last week and now has four goals and one assist this season, with all of those involvements coming at home.
Since the start of last season, 14 (seven goals, seven assists) of Rodriguez's 16 goal contributions in regular-season matches have come at home.
Charlotte FC – Ashley Westwood
Charlotte have failed to score in two of their last three games, and a lack of creativity has been a theme of their campaign to date.
Captain Westwood leads all Charlotte players for chances created this season, with 13, and he could be key if they are to hit the goal trail.
MATCH PREDICTION – NEW YORK CITY WIN
Charlotte are unbeaten in five all-time meetings with New York (four wins, one draw), including a 1-0 win over them in the teams' season opener on February 24.
The Crown are the only team NYCFC have faced more than once in MLS play and never defeated, but that may just change this week.
New York have won back-to-back matches to nil, a major defensive upturn after they managed just one clean sheet in their previous 10. Charlotte, meanwhile, have only earned one point from four road games in MLS this year, losing their last three in a row.
OPTA WIN PROBABILITY
New York City – 51.8%
Charlotte FC – 21.1%
Draw – 27.1%
FC Cincinnati v Colorado Rapids: Armas wants players to enjoy rise
Chris Armas says his Colorado Rapids players deserve to enjoy their meteoric rise up the MLS standings, and he is confident they will not get carried away ahead of their trip to FC Cincinnati.
Colorado sit fourth in the Western Conference with 15 points from nine games, winning three of their last four after an inconsistent start to the year.
They benefitted from two own goals as they beat FC Dallas 2-1 last time out, and Armas has no issue with his players enjoying their place in the standings, particularly given they finished rock bottom of the West in 2023.
"I see the boys looking at the TV where we have the standings posted, and they see that we're climbing, so it's all good stuff," Armas said.
"From day one the message that I preached is that everything we do will be based on hard work and that we will never get too low on ourselves.
"We don't get too high, the boys are realistic. That part's not that hard and our group is hungry and looking to improve every day."
Supporters' Shield holders Cincinnati have had an up-and-down start, going unbeaten through their first five games of the year before suffering back-to-back defeats against the New York Red Bulls and CF Montreal (both 1-2).
However, Pat Noonan's men bounced back with a statement 2-1 victory over Atlanta United last week, and defender Matt Miazga hopes that result will be a turning point.
"I look at everybody and I'm like, 'Alright, I see in his face, I see in his face. We want it,'" Miazga said.
"We all realised we are a top team, with big personalities, big characters, and it's time to show up in big moments."
PLAYERS TO WATCH
FC Cincinnati – Luciano Acosta
Acosta assisted Cincinnati's equaliser against Atlanta last Saturday before scoring the winner two minutes later.
That was Acosta's 13th regular-season match with a goal and an assist since the start of the 2022 season, three more than any other player in MLS has managed during that time.
Colorado Rapids – Djordje Mihailovic
Mihailovic has created at least twice as many chances as any other Colorado player in MLS this term (16), with Keegan Rosenberry and Sam Vines creating eight apiece.
He also has two goals and one assist to his name, while only Rafael Navarro (16) has bettered his 10 successful dribbles among his team-mates.
MATCH PREDICTION – FC CINCINNATI WIN
Cincinnati earned their first win over the Rapids last May, triumphing 1-0 on the road. The Rapids had won the first two meetings between the sides, including a 2-0 victory on their only previous trip to Cincinnati.
The Rapids also enter Saturday's game having won successive regular-season matches for the first time since September 2022, eyeing their first three-game winning streak since August 2021.
However, Cincinnati ended their poor run by beating Atlanta last time out and have, despite some underwhelming performances, only lost two of their nine league games this term (four wins, three draws). On home soil, the Supporters' Shield holders are favourites.
OPTA WIN PROBABILITY
FC Cincinnati – 49.3%
Colorado Rapids – 23.3%
Draw – 27.4%
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