Thomas Tuchel will expect Chelsea to mark his 50th Champions League game as a boss with a win at Lille and Juve will be favourites to knock Villarreal out on Wednesday.
There is huge uncertainty at Stamford Bridge after Roman Abramovich put the club up for sale before having his assets frozen by the United Kingdom government, but the London club have won four consecutive games.
The holders travel to Lille for the second leg of the round-of-16 tie with a 2-0 lead courtesy of goals from the in-form Kai Havertz and Christian Pulisic.
Juve and Villarreal will start their showdown at the Allianz Stadium locked at 1-1 after Dani Parejo equalised following Dusan Vlahovic's early strike.
Stats Perform picks out the standout Opta data ahead of the two games.
Lille v Chelsea
Havertz has become the Blues' main man, scoring four goals in his past three matches and six in seven.
Chelsea head coach Tuchel has won 31 of his 49 matches and can set a record for the most victories in his first 50 games as a boss in the competition with another success in Lille, as he is currently level with Zinedine Zidane's tally.
Lille's chances of forcing their way back into the tie appear to be slim, as not only do they trail by two goals, they have lost their past three Champions League games against the Premier League club.
They have also been eliminated from each of their three previous European knockout ties after losing the first leg.
The last side to progress against Champions League holders after failing to score in the opening leg was Arsenal versus Milan in 2007-08, with the first leg a goalless draw.
Each of Chelsea's past 11 wins in the Champions League have come with a clean sheet, 10 of which have come under Tuchel in just 14 matches.
Juventus v Villarreal
January signing Vlahovic set a record for the quickest goal by a Champions League debutant when he was on target after only 32 seconds of the first leg.
Juve are without a win in each of their past seven first-leg games in the Champions League (D3 L4), going on to be eliminated from four of their previous five knockout ties in the competition.
Villarreal have won their past two away games in the Champions League, the same number of victories as they managed across the 15 such matches beforehand.
Juve have only lost three of their previous 23 Champions League matches at home to Spanish sides in this competition, winning 12 and drawing eight.
This will be Villarreal’s first visit to Juventus in any competition as they scent a place in the quarter-finals.
Juan Cuadrado is in line to make his 50th appearance for Bianconeri in the Champions League. He has provided 11 assists for the Serie A giants in the competition, which is the most by any player in the period since he first joined the club in 2015.
Lille 1-1 Juventus: French side's resistance broken after second-half penalty
Lille held firm to hold Juventus to a 1-1 draw at home on Tuesday in the Champions League, extending their unbeaten run to nine matches.
Jonathan David had fired the French club ahead in the first half, before Dusan Vlahovic scored a second-half penalty to level things up and leave both sides on seven points after four matches.
Things didn't start well for the home side, with Teun Koopmeiners thinking he had scored the opener for Juventus only for it to be disallowed for offside.
David put Lille ahead just three minutes later with their first chance of note in the match. The Canadian turned home to convert from a slick counter-attacking move.
Goalkeeper Lucas Chevalier had to be on form to keep the home side ahead before half-time, sensationally saving a Vlahovic half-volley 10 minutes before the break. Koopmeiners, meanwhile, had another effort chalked off in the 42nd minute.
Juventus upped the pressure in the second half, with Chevalier also upping things and pulling off two impressive saves in quick succession.
But ultimately, the Lille resistance was broken by a Vlahovic penalty on the hour after Francisco Conceicao had been fouled by Benjamin Andre.
The result leaves Juventus 10th and Lille 12th in the Champions League table.
Data debrief: Lille looking good for qualification
After drawing 1-1, Lille are unbeaten in nine matches in all competitions and three matches in the Champions League.
The French side had beaten Atletico Madrid and Real Madrid in back-to-back European games.
They now have a seven-point buffer between themselves and the bottom eight in the league table.
Al-Nassr 5-1 Al-Ain: Ronaldo on target in AFC Champions League win
Cristiano Ronaldo powered Al-Nassr to a convincing 5-1 triumph over Asian Champions League Elite holders Al-Ain on Tuesday.
The victory carried a sense of redemption for Al-Nassr as they avenged last season's semi-final defeat to the same opposition on their way to lifting a second title in the competition.
Talisca fired the hosts into a fifth minute lead with a well-taken effort from the edge of the box before Ronaldo poked home his 908th career goal just after the half-hour mark.
Visiting defender Fabio Cardoso then deflected Angelo's effort beyond Khalid Eisa to hand Al-Nassr a comfortable advantage at the interval.
Al-Ain did, however, pull one back early in the second half when Park Yong-woo's strike struck the post and went in off the back of Al-Nassr goalkeeper Bento.
But the result was put beyond doubt late on when Wesley curled home Al-Nassr's fourth, before Talisca notched his brace in second half stoppage time.
Data Debrief: Return of Ronaldo
After winning five Champions League across his glittering career, Ronaldo is now eyeing a first AFC Champions League crown with Al-Nassr.
The 39-year-old has six goals in eight appearances in the competition, with his goal against Al-Ain ending a three-game goal drought for Al-Nassr.
Ronaldo also registered a team-high expected goals (xG) tally of 1.25 towards Al-Nassr's 2.67 total, while also producing more shots (eight) and touches in the opposition box (nine) than any other player on the pitch.
Neymar suffers fresh injury blow
Neymar sustained a new injury as he was forced off during Al-Hilal's AFC Champions League Elite win over Esteghlal.
Aleksandar Mitrovic plundered a hat-trick on Monday to seal a 3-0 win.
But Al-Hilal's victory was soured by an injury to Neymar, who had to make way just 29 minutes after he came on as a second-half substitute.
The Brazilian, who has just returned from over a year out of action following a serious knee injury, was forced off with what appeared to be a thigh issue.
Indeed, Monday's appearance was only the 32-year-old's second for Al-Hilal since his comeback.
He has featured just seven times for the Saudi Pro League champions in all competitions since his big-money move from Paris Saint-Germain in 2023.
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