Thomas Tuchel will expect Chelsea to mark his 50th Champions League game as a boss with a win at Lille and Juve will be favourites to knock Villarreal out on Wednesday.
There is huge uncertainty at Stamford Bridge after Roman Abramovich put the club up for sale before having his assets frozen by the United Kingdom government, but the London club have won four consecutive games.
The holders travel to Lille for the second leg of the round-of-16 tie with a 2-0 lead courtesy of goals from the in-form Kai Havertz and Christian Pulisic.
Juve and Villarreal will start their showdown at the Allianz Stadium locked at 1-1 after Dani Parejo equalised following Dusan Vlahovic's early strike.
Stats Perform picks out the standout Opta data ahead of the two games.
Lille v Chelsea
Havertz has become the Blues' main man, scoring four goals in his past three matches and six in seven.
Chelsea head coach Tuchel has won 31 of his 49 matches and can set a record for the most victories in his first 50 games as a boss in the competition with another success in Lille, as he is currently level with Zinedine Zidane's tally.
Lille's chances of forcing their way back into the tie appear to be slim, as not only do they trail by two goals, they have lost their past three Champions League games against the Premier League club.
They have also been eliminated from each of their three previous European knockout ties after losing the first leg.
The last side to progress against Champions League holders after failing to score in the opening leg was Arsenal versus Milan in 2007-08, with the first leg a goalless draw.
Each of Chelsea's past 11 wins in the Champions League have come with a clean sheet, 10 of which have come under Tuchel in just 14 matches.
Juventus v Villarreal
January signing Vlahovic set a record for the quickest goal by a Champions League debutant when he was on target after only 32 seconds of the first leg.
Juve are without a win in each of their past seven first-leg games in the Champions League (D3 L4), going on to be eliminated from four of their previous five knockout ties in the competition.
Villarreal have won their past two away games in the Champions League, the same number of victories as they managed across the 15 such matches beforehand.
Juve have only lost three of their previous 23 Champions League matches at home to Spanish sides in this competition, winning 12 and drawing eight.
This will be Villarreal’s first visit to Juventus in any competition as they scent a place in the quarter-finals.
Juan Cuadrado is in line to make his 50th appearance for Bianconeri in the Champions League. He has provided 11 assists for the Serie A giants in the competition, which is the most by any player in the period since he first joined the club in 2015.
Gravenberch ready to show off Liverpool form ‘to the world’, says Gakpo
Liverpool’s Cody Gakpo expressed his pride in seeing compatriot Ryan Gravenberch show off his qualities ‘to the whole world’ after a fine start to the Premier League season.
Though the Netherlands pair did not become teammates at Liverpool until late summer of 2023, Gakpo knew well Gravenberch’s talents from their respective Eredivisie spells with PSV Eindhoven and Ajax.
Now in his second season at Anfield, Gravenberch has drawn widespread plaudits for his form in a new deeper-lying midfield role under new head coach Arne Slot, having largely been used as a substitute under Jurgen Klopp.
Gravenberch is the only midfielder in Europe's big-five leagues to both make 30+ tackles (30) and 30+ interceptions (33) in all competitions this season, and Gakpo insisted that his Netherlands team-mate can continue to go from strength to strength, starting against Southampton this Sunday.
“We [the Dutchmen at Liverpool] knew Ryan already from the Eredivisie when he played at Ajax, and I think everybody knew already that he is this good,” Gakpo recently told Men in Blazers.
“After that, he made a move to Bayern Munich, and maybe he didn’t play that much over there, but still everybody in Holland knew how good he could be when he was playing.
“And I think maybe the manager [Slot] also knew this. At the beginning of the season, he put him in a slightly different position, but he gave him the confidence to play there.
“Ryan showed his quality in that position, grabbed his chance as well and turned out to be a good match. He is playing outstandingly for us this season.
“I’m very happy that we can see Ryan, as we Dutchmen already knew, but now he can show it to the whole world. I’m very proud of him.”
Southampton, meanwhile, welcome the Reds to St. Mary’s on the back of a 2-0 defeat to Wolves ahead of the international break, leaving them bottom of the table after 11 games of the season.
The Saints are the lowest scorers in the Premier League this season (seven), while only Crystal Palace (5.1%) have a lower shot conversion rate than Russell Martin’s side (6.2%). Just 30.1% of Southampton’s shots have been on target this term (34/113), a league-low ratio.
However, the Southampton head coach is relishing the opportunity of facing Liverpool, with his players performing well against the likes of Arsenal and Manchester City already this term.
"I'm really excited about Sunday. We're playing the best team in the country at the moment, on their current form and what they have been doing with their manager, built on an incredible foundation from the previous manager, so I'm really looking forward to it,” Martin said.
"I think we showed the guys the Premier League table last season and how much it changed by the end and by the end of December. But it's honestly such an exciting month.
"People talk about the difficulty of the game and every competition we face in the next four or five games, but it's what we all worked so hard for. We should be excited about the challenge.
“I think teams have shown in the last few weeks that you can pick up big results against big teams, good opposition, and we are going to have to. Our level of performance against teams at the top end of the table has been good on the whole."
PLAYERS TO WATCH
Southampton – Mateus Fernandes
Fernandes has become a mainstay in the Southampton team, starting the last eight Premier League games in a row, and has been one of Martin’s standout performers in a lacklustre start to the campaign.
In the Saints’ 2-0 defeat to Wolves last time out, the Portuguese contributed a team-high expected goals (xG) tally of 0.22 from his three shots, while only Yukinari Sugawara (10) and Flynn Downes (12) have created more chances in the top-flight than Fernandes (eight) this season.
Liverpool – Mohamed Salah
Salah has both scored and assisted in the same match 35 times in the Premier League (including four already this term), just one shy of Wayne Rooney’s record of 36 games with both a goal and an assist in the competition. The Egyptian has been directly involved in 11 goals (seven goals, four assists) in 11 Premier League appearances against Southampton.
He has also been directly involved in 67% of Liverpool’s Premier League goals this season (14/21 – eight goals, six assists), the highest ratio by a player for any side in the division in 2024-25. Indeed, only Matt Le Tissier for Southampton in 1993-94 (69% - 34/49) has scored or assisted a higher proportion of a side’s goals in a single season in the competition.
MATCH PREDICTION: LIVERPOOL WIN
Liverpool have won nine of their 11 Premier League games under new head coach Slot (D1 L1). A win over Southampton will see the Dutchman become the joint-fastest manager to reach 10 wins from the start of a Premier League career (12 games), alongside Guus Hiddink in May 2009 and Carlo Ancelotti in November 2009 (both with Chelsea).
The Reds’ last Premier League game against the Saints was a 4-4 away draw in May 2023 – they conceded as many goals in that game as they had in their previous six visits to St Mary’s combined.
Southampton have won just one of their last 14 Premier League games against Liverpool (D3 L10), a 1-0 home victory in January 2021.
This will also be the first Premier League match between the side starting the day bottom of the table and the side starting the day top since April 2023, and Southampton’s 3-3 draw away to Arsenal. The league leaders are unbeaten in 14 such matches (W12 D2) since Wolves won 2-1 against Manchester United in February 2011.
However, Southampton have only lost one of their last eight Premier League home games against sides starting the day at the summit (W2 D5) and are unbeaten in their last four (W2 D2 – including a 1-0 win over Liverpool in January 2021) since a 0-1 defeat to Man City in May 2018.
But Martin’s side have lost nine of their 11 Premier League games this season (W1 D1). Only seven sides in English top-flight history have reached 10 defeats in 12 or fewer matches from the start of a campaign, with all seven going on to be relegated.
OPTA WIN PROBABILITY
Southampton – 9.7%
Draw – 12.6%
Liverpool – 77.7%
Taylor proud of 'gritty' Man City display in Hammarby victory
Gareth Taylor was pleased with how his Manchester City players handled the atmosphere against Hammarby to secure their passage into the Champions League quarter-finals.
Khadija Shaw opened the scoring in the 31st minute before Ellen Wangerheim restored parity shortly after the interval with a finish from close range.
But Shaw continued her fine start to the campaign, scoring the winner to become City's all-time top scorer in the competition, surpassing Georgia Stanway and Janine Beckie (both six).
The result saw City make it to the last eight of the competition for the first time since 2021, though the encounter was far from comfortable at the Tele2 Arena on Thursday.
Hammarby ended the contest with an expected goals (xG) total of 2.15 compared to the visitors' 1.07, despite both sides having 14 shots throughout the match.
However, City maintained their unbeaten record against Swedish sides in the competitor (W6), and Taylor was proud of his side's "gritty" display in Stockholm.
“I’m really pleased. It was about qualification for us tonight," Taylor said.
"There were a couple of ways we could do it. Obviously, we knew a point was enough, but I don’t think the players were thinking that way.
“It was a really gritty performance on a really difficult on this pitch. It probably doesn’t look like that for the viewers at home watching it.
"But it was a really lively surface and we worked so hard.
“I felt there were some areas we could control the play better. I have to give credit to Hammarby, they were really aggressive.
"The referee was on our side a little bit in the first half and maybe not in the second.
“I’m really pleased and proud of the players, they really dug in tonight. You come away from a hostile environment with a win.”
McKenna fired up for 'biggest game in world football' against Man United
Kieran McKenna believes Ipswich Town's Premier League clash with Manchester United will be the "biggest game in world football" this weekend.
United are in action under new manager Ruben Amorim for the first time since the Portuguese officially replaced Arne Slot as head coach.
While plenty of focus is on the visitors at Portman Road, Ipswich are fired up after beating Tottenham 2-1 before the international break.
That was Ipswich's first league win of the season – and their first in the Premier League in 22 years – and now attention turns to facing United.
McKenna, who previously coached United, said at a fan event this week: "Sunday, what a game. It's one we're really, really looking forward to.
"Not for the personal connection, but as manager of Ipswich Town, to be on that stage, it's what we've worked so hard for.
"It's the biggest game in world football anywhere this weekend, the biggest game in the world in the biggest sport in the world and it's at Portman Road."
Ipswich's surprise win at Tottenham last time out moved them up to 17th, while United are 13th after beating Leicester City 3-0 in Ruud van Nistelrooy's final game in caretaker charge.
Amorim took his first training session on Monday, albeit with many first-team stars away on international duty, and the former Sporting CP boss believes his style of play will be clear to see from the off.
"I think you will see an idea," he told the club's website. "You could like it or not, I don't know, but you will see an idea.
"You will see a positioning. You will see something that we want to reach that kind of level. You will feel that.
"We have to know it's [only] two trainings before the first match. This is the best league in the world. But if I have to say something to you, [it's that] you will see an idea. This I can guarantee."
PLAYERS TO WATCH
Ipswich Town - Liam Delap
Delap scored what proved to be Ipswich's winner against Tottenham and has now netted six of his side's 12 Premier League goals this term.
That makes the Manchester City academy product one of only three players to have scored at least half of his side's goals in the competition this season, along with Erling Haaland at City (55%) and Chris Wood at Nottingham Forest (53%).
Manchester United - Alejandro Garnacho
Garnacho was among the scorers against Leicester two weeks ago and has now been directly involved in 20 Premier League goals for United (13 goals and seven assists).
The Argentina international is one of only two non-British players to reach that figure for United before turning 21, along with Cristiano Ronaldo (25 goals).
MATCH PREDICTION: MANCHESTER UNITED WIN
Ipswich are seeking back-to-back Premier League wins for the first time since February 2022, with that run also beginning with a 2-1 victory against Tottenham.
The Tractor Boys are the only side in the competition without a home win this season. Only five newly promoted clubs have failed to win any of their first six home matches, all of whom went back down.
United have won 17 of their past 19 Premier League games against newly promoted opponents, meanwhile, including nine wins in a row in away fixtures.
The Red Devils were 1-0 winners on their most recent league trip to Portman Road in April 2022, but only once have they won successive league games away to Ipswich.
However, the Tractor Boys have lost four of their past five league matches against Man United, failing to score in each of those losses.
OPTA WIN PROBABILITY
Ipswich Town - 22.2%
Draw - 23%
Manchester United - 54.8%
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