Roy Keane called for Manchester United to dump their derby flops as he attacked "shameful" effort levels in the 4-1 defeat to Manchester City.
Along with fellow 1999 treble winners Gary Neville and Peter Schmeichel, Keane said the performance from United was unacceptable at the Etihad Stadium.
Doubles from Kevin De Bruyne and Riyad Mahrez left United to reflect on a wretched afternoon at the home of their neighbours.
A first-half strike from Jadon Sancho had briefly brought United level, as they began the game well enough before fading alarmingly.
Keane said on Sky Sports: "They did give up, and for a player in any game to give up, it's unforgivable really.
"The beauty of top-level sport is there's no hiding place. I know United have done well here the last couple of years. We saw all the United shortcomings today.
"There's ways to lose football matches. We've all lost football matches. But the way United lost it today, they stopped running, they gave up. There are players not running back, that's what I don't understand."
Ralf Rangnick, the interim manager, had led United on an eight-game unbeaten run in the Premier League before this crushing blow.
"The manager will be criticised, and the tactics," said Keane. "But players not running back when you're playing for Man United, it's really unacceptable, it really is. They threw the towel in, which is shameful.
"It's hard when you're out there and you're up against a really good team and they're keeping the ball and you can't get it back, but I go back to it, we see some of the goals and you've got to run back, you've got to tackle.
"United players have shown quality over the years but we've just seen a reflection of where the team is and where the club is. It's just so far behind the other teams."
Sunday's results saw United slip to fifth, as Arsenal went above them with a 3-2 win at Watford earlier in the day.
Keane suspects there is more to United's troubles than may meet the eye, casting a degree of doubt before kick-off on the reason for Cristiano Ronaldo's absence, which was put down to a hip problem.
But he sees no excuse for United's players letting their focus drift.
"Whatever's gone in the dressing room, and we hear noises all the time, and we hear about problems obviously with the new manager maybe coming in, and recruitment," he said.
"But your own bit of pride eventually has to kick in at some stage. There were five or six players who should never play for Manchester United again. Just shameful, shameful that you can't run back and put your body on the line.
"I thought City had a couple of gears to go. They toyed with them. They [United] gave up, and shame on them."
Schmeichel, speaking on BBC Radio 5 Live, felt United were ripe for being picked off and need to look at themselves.
The former goalkeeper said: "I thought Rangnick should have changed things at half-time. He may have had words, but the second half was worse; at no point were United in the game apart from on the scoreline.
"Far too many players are either not good enough, or don't care enough. Having an interim manager means he can't do much; he knows he's not going to be there, so what can he change?
"There are players whose contracts are running down. [Paul] Pogba started the game, big question marks over whether he's going to stay. [Substitute Jesse] Lingard has said he doesn't want to be there. But for all that, Man City showed, in difficult circumstances, that they are the best in the country."
Guardiola has 'no words' for hat-trick hero Haaland
Pep Guardiola was lost for words to describe Erling Haaland after his eighth Premier League hat-trick fired Manchester City to a 3-1 victory over West Ham.
Having scored a treble to help City claim a 4-1 win over Ipswich Town on matchday two, Haaland did likewise on Saturday to keep them perfect as they edged out the Hammers at the London Stadium.
Haaland's seven goals this season are the most any player has ever netted in the first three matches of a Premier League campaign, while only Sergio Aguero (12), Alan Shearer (11) and Robbie Fowler (nine) have ever helped themselves to more match balls in the competition.
Across English football's top four tiers, he is also the first player to score two hat-tricks in a team's first three games of a league season since Bradford City's Paul Jewell in 1994-95.
The Norwegian has now scored more than once in 26% of his Premier League matches (18/69, eight hat-tricks, 10 braces), leaving Guardiola in disbelief.
"There are no words for him," Guardiola told BBC Sport.
"All we can do is make him play better and better and give him as many balls as possible into the box. It's what we have to do. We are there and we added quality.
"This is a team. When you have to run backward, no one asks who has to do it. Everyone has to. When we see Erling doing that, it is fantastic."
Haaland himself, meanwhile, believes having an extended pre-season due to Norway missing out on Euro 2024 has helped him start the season in peak condition.
"I feel good. I feel energised. I had a long vacation and a long pre-season. I'm feeling good," Haaland told City's website.
"The years here have gone quick and it's been going like, 'bam bam bam', now I have a little bit of rest in my body and my feet. I feel really good now and I'm ready for more.
"I feel more refreshed and more energised. So when you do that you can practice on things you want to become better at in training. I feel good. I want to become better. I'm happy."
City sit top of the early-season table with nine points from nine available and saw last season's runners-up Arsenal slip up on Saturday, drawing 1-1 with Brighton and Hove Albion.
Haaland, though, feels it is too early to think about the title race, adding: "They [City's rivals] haven't slipped up yet. Three games, nine points. This is a great start.
"But let's not think too far ahead, because there’s potentially 70 games left this season. Let's breathe a bit and take it game by game."
Lopetegui rues missed opportunity as West Ham lose to Man City
West Ham manager Julen Lopetegui was not encouraged by the performance of his team despite losing 3-1 at home to Manchester City in their third league game.
“It is true that City is one of the best teams around the world for sure… but it is also true too that in the second half we have been very close to a draw,” he said speaking to BBC Match of the Day.
“I think we have played one very good second half. The start has been very good for us too.”
West Ham threatened for extended periods of the match and had chances to level the match at 2-1 down, with the best coming from Mohammed Kudus as he smashed a shot against the bar in the second half.
They also started the game brightly before going a goal down inside 10 minutes.
“In my mind we started very well, being aggressive,” said Lopetegui.
“We know in this plan normally they have initiative, it’s very difficult to not concede initiative then. That’s why you have to do a lot of very good things to overcome them.
“In the second half we had chances, I think we kept the ball much more, much more, and didn't concede a lot of chances."
But the hosts were ultimately undone by the brilliant finishing of Erling Haaland, who scored his second hat-trick in as many matches.
“He is one of the best players in the world, that's why he plays for Manchester City,” he said.
“You have to compete with these kind of players. City has the power and the quality to create chances.”
But ultimately, he was left frustrated at the sense of a missed opportunity and that his team were unable to earn themselves a draw that hadn’t seemed implausible during the match.
“Today I think the first goal was a pity for us but I’ve said it. I was happy with the performance think we were able to draw but again they damage us,” he said.
“Against this kind of team, if you make a mistake they don’t forgive. This is the difference they have… A little mistake they punish you, they punish us.
“We have to improve, to know to compete against this kind of team to be close to perfection.
“Don't make mistakes, be calm, defend well… we have quality players too.”
Sancho given fresh start with Chelsea loan move
Jadon Sancho has secured a move away from Manchester United, having joined Chelsea on Deadline Day on a season-long loan.
The deal includes an obligation to buy for between £20-£25 million at the end of the loan, according to widespread reports, meaning that the 24-year-old will not be returning to Old Trafford next summer.
Work to complete the transfer came late on Deadline Day, with a deal sheet being submitted to ensure the signing could go through after the 11pm deadline.
Chelsea were able to get the deal over the line, confirming the move was complete on Saturday evening.
"I’m really excited to be here," Sancho said. "London is where I grew up and I’m happy to be back.
"The manager spoke to me about the project and, for a young player, it's exciting. Hopefully I can bring goals and assists to the Bridge."
It brings an end to a three-year spell at Old Trafford for Sancho. The winger originally joined United on a five-year contract in 2021 but, following a public falling out with manager Erik ten Hag, found his first-team opportunities limited.
Sancho made 83 appearances in all competitions for United, but his last start for the club came against Manchester City in the 2023 FA Cup final. He made three substitute appearances in August 2023 before moving back to Dortmund on loan in January, where he scored three goals in 21 appearances.
His final outing in a United shirt came off the bench in their Community Shield defeat to Manchester City, but he was not included in the squad for the first two league games.
Sancho joins a club with plenty of competition for attacking places, with Cole Palmer, Christopher Nkunku, Nicolas Jackson, Pedro Neto, Joao Felix and Noni Madueke among their roster.
Chelsea did also manage to move some players on during Deadline Day. Raheem Sterling secured a loan move to Arsenal on Deadline Day, while Trevoh Chalobah joined Crystal Palace, Armando Broja moved to Everton and Djordje Petrovic was loaned by Strasbourg.
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