Kai Havertz and Christian Pulisic put Chelsea in control of their Champions League last-16 tie against Lille with a 2-0 win, but Mateo Kovacic and Hakim Ziyech went off injured.
Despite Romelu Lukaku being dropped to the bench after a dismal showing against Crystal Palace on Saturday, Chelsea needed just eight minutes to find the net through Havertz.
The reigning champions saw in-form duo Kovacic and Ziyech hobble off before the hour mark, casting doubt over their chances of featuring in the EFL Cup final against Liverpool on Sunday.
Pulisic finished off a quick break after 63 minutes to secure a strong first-leg lead for Thomas Tuchel's side, with the return leg to come in France next month.
Havertz wasted little time in making his mark as the central striker, nodding home from Ziyech's corner after failing to take a couple of early chances.
Antonio Rudiger almost turned a Renato Sanches cross into his own net and Lille threatened with a flurry of chances from the resulting corner as they started to get a foothold in the game.
Chelsea were dealt a blow when they lost Kovacic and Ziyech in quick succession early in the second half, but they doubled their advantage in the 63rd minute.
N'Golo Kante surged forward from inside the Chelsea half and fed Pulisic for a delightful dink over the onrushing Leo Jardim and into the bottom-right corner.
Lille tried to reduce the arrears with a push for a late goal, but Edouard Mendy was never really tested and Chelsea remained in charge of the tie.
What does it mean? Advantage Chelsea
The Blues were always going to be the favourites in this match-up and they got the win that was expected of them despite being far from dominant.
Chelsea have a good record when winning the first leg of a Champions League tie; in the 11 occasions they have won the opening encounter, they have reached the next round nine times.
However, the two exits followed first-leg victories at Stamford Bridge against Barcelona in 1999-2000 and Liverpool in 2006-07.
No room for Romelu
Lukaku was dropped after having just seven touches across 90 minutes at the weekend. Havertz needed just five to have three attempts on goal and find the net with the last of them, showing he is more than capable of being a potent threat through the middle.
Sanches shines in defeat
Sanches proved he has come a long way as he returned to the ground where he infamously passed to a logo on an advertising board, which he had mistaken for a team-mate during an underwhelming loan spell at Swansea City in 2017. He bossed the midfield in the first half and played some lovely passes.
What's next?
Chelsea face Liverpool in the EFL Cup final at Wembley on Sunday, when Lille travel to Lyon in Ligue 1.
Returning fan favourite Alonso calls Liverpool 'one of Europe's best'
Bayer Leverkusen coach Xabi Alonso hailed his former club Liverpool as "one of Europe's best" as he prepares for his Anfield return.
Alonso, who spent five successful years at Anfield and helped Liverpool win the Champions League in 2005, returns to his former stomping ground when Leverkusen take on the Reds on Tuesday.
Arne Slot has won 12 of his first 14 matches in charge of Liverpool, including all three in the Champions League so far.
Leverkusen have only won one of their 11 away major European matches in England (D3 L7), and have lost their last two visits to Anfield, and Alonso is under no illusion as to the scale of the task that awaits the reigning Bundesliga champions.
"For us, it is a big challenge," he said.
"Liverpool at the moment are one of the best, if not the best, in Europe, they are showing that in the Premier League and Champions League, a good squad, great coach. We're looking forward to it. Let's see what happens.
"You can play 70 minutes great but in 20 minutes it [the game] is gone, so it is mentally and emotionally we need to be ready.
"In all areas, they are really strong, so the process works really well. [Slot] has done a fantastic job in three months."
Alonso played 210 times across all competitions for Liverpool between 2004 and 2009, scoring 18 goals and providing 20 assists.
After winning the Champions League with the Reds in 2005, he helped them reach the final in 2007, though they lost to Milan on that occasion.
However, the Spaniard does not think he will have too much time for a trip down memory lane.
"Unfortunately, there is no time for tourism – maybe a little run or walk," he said.
"I know the city very well, I love it, but tomorrow I will focus on the game and only the game.
"It feels great to be back here after a few years. It's always special. You notice the development of the club; the new stand looks amazing.
"It is a big game against Liverpool, it cannot get much better than that."
The omens are not great for Leverkusen, though.
Liverpool have lost one of their last 21 European meetings with German opponents (W14 D6), albeit that one defeat came against Leverkusen in 2002.
Neymar suffers fresh injury blow
Neymar sustained a new injury as he was forced off during Al-Hilal's AFC Champions League Elite win over Esteghlal.
Aleksandar Mitrovic plundered a hat-trick on Monday to seal a 3-0 win.
But Al-Hilal's victory was soured by an injury to Neymar, who had to make way just 29 minutes after he came on as a second-half substitute.
The Brazilian, who has just returned from over a year out of action following a serious knee injury, was forced off with what appeared to be a thigh issue.
Indeed, Monday's appearance was only the 32-year-old's second for Al-Hilal since his comeback.
He has featured just seven times for the Saudi Pro League champions in all competitions since his big-money move from Paris Saint-Germain in 2023.
Juve must play at their limits against in-form Lille, warns Motta
Thiago Motta stressed the importance of Juventus playing at their very best when they face Lille in the Champions League on Tuesday.
Juve face a tough task against a side who have already upset Real Madrid and Atletico Madrid in this season's competition.
This will be the first ever meeting between these teams.
However, Juve have lost three of their last four Champions League matches against French opponents (W1), including both against Paris Saint-Germain in the 2022-23 campaign. and Motta warned against any complacency.
"All matches are important. We, as Juventus, always want to win. The most important thing is always trying to improve," Motta told reporters on Monday.
"Lille are very confident, and we want to face them in optimal condition. We aim to give more than our maximum.
"There are no favourites in a match. It's a beautiful game, in a beautiful stadium, and we hope the pitch will be in good condition tomorrow. We can only talk tomorrow about who played better."
Motta will have midfielder Douglas Luiz from injury, but is still without a glut of players.
"He's [Luiz] one more player who can help the team. We’ll be missing Arek [Arkadiusz Milik], Gleison [Bremer] and [Nicolas Gonzalez]."
Lille boss Bruno Genesio knows Juve will present a stern test for his team, despite their shock wins over the Madrid clubs this term.
"Every Champions League match is different, but there is one essential parameter to get a result - commitment," he said.
"Like all Italian teams, Juventus are very well organised, very difficult to play against. Having already achieved two big results in this competition, we are going to give it our all again and we have our fans who will give us strength."
Jonathan David will be one of the standout Lille players Juve have to keep a close eye on.
The Canada international has scored six goals in his last eight Champions League appearances for Lille.
Lille have won all five games he has scored in but have not won any of the six games he has featured in without scoring (D2 L4).
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