Edinson Cavani will miss the first leg of the Champions League last-16 tie between Manchester United and Atletico Madrid.
The striker is still being troubled by a groin problem, having missed the Red Devils' past three Premier League matches.
Interim manager Ralf Rangnick said the Uruguay international has been unable to train for two weeks and does not feel capable of running at full capacity, meaning there is little point in including him in the squad for Wednesday's match.
"No, Edi will not be able to make the trip," he told reporters on Tuesday. "He didn't train and hasn't been training for the last couple of weeks.
"He has problems with his groin and as long as he doesn't feel ready to fully sprint, it doesn't make sense to train him."
Cavani has scored two goals in 11 games in a season blighted by persistent unavailability.
Having been persuaded to stay at the club for another year by Ole Gunnar Solskjaer after impressing in 2020-21, Cavani has missed 20 of United's 35 matches in all competitions, last playing in the 1-1 draw at Burnley on February 8.
United allowed Anthony Martial to join Sevilla on loan in January but did not sign a replacement, meaning 37-year-old Cristiano Ronaldo will be their only recognised centre-forward for the game at the Wanda Metropolitano.
The Portugal star has scored 25 goals in 35 appearances against Atleti in his career, netting three hat-tricks against Diego Simeone's side, two in the Champions League.
Rangnick, whose side battled to a 4-2 league win at Leeds United on Sunday, said: "We have made sure the players could recover in the last few days and maybe we will have some fresh legs on the pitch. We will see tomorrow.
"Some of our players will not be received with the red carpet. We have some experience and some talented young players, so the balance is perfect.
"Mentally, we need to prepare for a very emotional, if not hostile, atmosphere. I don't think the game or the fixture will be decided tomorrow, it will be decided in the second leg at Old Trafford.
Sheffield United go second after late turnaround, Plymouth continue good home form
Sheffield United staged a late turnaround to win 2-1 away to Bristol City and go second in the Championship, one point behind leaders Sunderland who play on Wednesday.
The game started slowly, with the hosts not opening the scoring until a 75th-minute Anis Mehmeti penalty after a foul on Sinclair Armstrong by goalkeeper Michael Cooper.
The Blades showed great character to haul themselves back into the game, with 18-year-old Ryan One scoring the equaliser in the 86th minute.
But things went up a notch in stoppage time when Robert Dickie was given a straight red card for a cynical foul on Callum O'Hare 35 yards out.
The drama wasn't finished yet and with seconds to go, Harrison Burrows smashed home a left-foot rocket to win the game for the Blades.
At the bottom of the table, Plymouth opened a four-point gap between themselves and the relegation zone with a 1-0 victory over bottom-of-the-table Portsmouth.
The victory means that Wayne Rooney's side have dropped just two points in their last five games at Home Park, having lost six on the bounce in all competitions away.
It is now four without a victory for Portsmouth, who have earned just nine points in their opening 14 matches back in the Championship.
Elsewhere, Middlesbrough responded to their 3-0 defeat at home to Coventry City last weekend by beating second-bottom Queens Park Rangers 4-1 on the road.
That was a first victory in three for Michael Carrick's side, who are one place below the play-off positions and trail only by goal difference.
QPR are four points behind fourth-bottom Preston North End, having failed to win any of their last 10 league games.
Al-Nassr 5-1 Al-Ain: Ronaldo on target in AFC Champions League win
Cristiano Ronaldo powered Al-Nassr to a convincing 5-1 triumph over Asian Champions League Elite holders Al-Ain on Tuesday.
The victory carried a sense of redemption for Al-Nassr as they avenged last season's semi-final defeat to the same opposition on their way to lifting a second title in the competition.
Talisca fired the hosts into a fifth minute lead with a well-taken effort from the edge of the box before Ronaldo poked home his 908th career goal just after the half-hour mark.
Visiting defender Fabio Cardoso then deflected Angelo's effort beyond Khalid Eisa to hand Al-Nassr a comfortable advantage at the interval.
Al-Ain did, however, pull one back early in the second half when Park Yong-woo's strike struck the post and went in off the back of Al-Nassr goalkeeper Bento.
But the result was put beyond doubt late on when Wesley curled home Al-Nassr's fourth, before Talisca notched his brace in second half stoppage time.
Data Debrief: Return of Ronaldo
After winning five Champions League across his glittering career, Ronaldo is now eyeing a first AFC Champions League crown with Al-Nassr.
The 39-year-old has six goals in eight appearances in the competition, with his goal against Al-Ain ending a three-game goal drought for Al-Nassr.
Ronaldo also registered a team-high expected goals (xG) tally of 1.25 towards Al-Nassr's 2.67 total, while also producing more shots (eight) and touches in the opposition box (nine) than any other player on the pitch.
Neymar suffers fresh injury blow
Neymar sustained a new injury as he was forced off during Al-Hilal's AFC Champions League Elite win over Esteghlal.
Aleksandar Mitrovic plundered a hat-trick on Monday to seal a 3-0 win.
But Al-Hilal's victory was soured by an injury to Neymar, who had to make way just 29 minutes after he came on as a second-half substitute.
The Brazilian, who has just returned from over a year out of action following a serious knee injury, was forced off with what appeared to be a thigh issue.
Indeed, Monday's appearance was only the 32-year-old's second for Al-Hilal since his comeback.
He has featured just seven times for the Saudi Pro League champions in all competitions since his big-money move from Paris Saint-Germain in 2023.
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