Champions League holders Chelsea get their knockout campaign started on Tuesday as the defence of their crown enters an altogether more challenging stage.
Thomas Tuchel's men may feel they have dodged a bullet or two by getting this draw, with their next opponents Lille struggling to match the highs of their Ligue 1 title victory from last season in 2021-22.
Tuesday's other encounter sees Juventus travel to Villarreal, with Massimiliano Allegri looking to improve on the knockout exploits of Maurizio Sarri and Andrea Pirlo before him.
Here, Stats Perform delves into the Opta data to pick out the key statistical narratives and subplots ahead of Tuesday's games.
Chelsea v Lille
Much of the attention at Stamford Bridge will be on Romelu Lukaku, whether the Belgian plays or not.
The big-money signing's struggles this season have been well-publicised, but he hit a new low on Saturday as he touched the ball just seven times in the win over Crystal Palace – that is the fewest by any player to feature for 90 minutes in a single Premier League game since at least 2003-04.
On the other side of the contest is a striker aiming to emulate Lionel Messi. Jonathan David may not have scored a Ligue 1 goal since December but the talented Canadian impressed in the second half of the group stage.
He scored one goal in each of his last three appearances in the competitions, meaning if he scores on Tuesday he will be the second-youngest (22 years, 39 days) non-European to score in four successive Champions League games after Messi (21y, 155d in November 2008).
That is not to say Lille are a high-scoring side. Many will be wondering who let Les Dogues out of Group G, given their haul of seven makes them the lowest-scoring group winners since Leicester City and Atletico Madrid (seven each) in 2016-17. In fact, no team from that section scored more than eight.
The omens are, perhaps unsurprisingly, overwhelmingly in Chelsea's favour here. Only Manchester City (15) and Bayern Munich (14) have won more Champions League games than the holders since the start of last season, while Lille are appearing at this stage for just the second time ever.
Further to that, Tuchel boasts a fine record in Champions League knockout ties, having progressed from/won (including finals) eight of his previous 11 (73 per cent), a success rate bettered by only three managers (minimum 10 knockout ties): Vicente del Bosque (80 per cent - 8/10), Jupp Heynckes (86 per cent - 12/14) and Zinedine Zidane (88 per cent - 14/16).
Villarreal v Juventus
Sarri and then Pirlo were both tasked with establishing a new era at Juventus, but when Allegri returned after a two-year break in pre-season, he picked up the pieces of a side that had regressed significantly.
There remain plenty who feel Allegri never should have been re-hired, but this tie at least gives him an opportunity to point to a degree of progress – at least in the context of the Champions League.
After all, neither Sarri nor Pirlo got beyond the last 16. Allegri, on the other hand, was only eliminated at this stage once in five seasons, and that was to Pep Guardiola's excellent Bayern side.
His counterpart on Tuesday, Unai Emery, has something of a point to prove as well, but his has more to do with his own personal record.
While something of a specialist at Europa League level, having won the competition four times including last season, he has won only one of six knockout games in the Champions League.
Much of Emery's hope will be pinned on Arnaut Danjuma.
The Dutchman – who recently returned from two months out and scored a hat-trick at the weekend – had a hand in five goals in the group stage, which is already a joint-club record for the club in the competition.
By no means are the Yellow Submarine a one-man team, however. Young winger Yeremi Pino caught the eye in the group and is plotting to become only the fourth Spanish teenager to score in the knockout stages of the Champions League after Bojan, Cesc Fabregas and Raul.
Inzaghi expecting Arsenal reaction after Newcastle defeat
Inter boss Simone Inzaghi is expecting a difficult test against "one of the best teams in Europe" when Arsenal visit the San Siro in the Champions League on Wednesday.
Arsenal come into the encounter against the reigning Serie A champions on the back of a defeat to Newcastle United in the Premier League last weekend.
Mikel Arteta's side have now lost two of their last three league games, having tasted defeat just once in their 25 games in the top-flight (W21 D3) in 2024.
But Inzaghi, who helped Inter keep pace at the Serie A summit with a controversial 1-0 win over Venezia, is expecting a reaction from the Gunners.
"We are facing one of the best teams in Europe, very recognisable with a great coach," Inzaghi said.
"We all know how the big teams react after a defeat. Look at us after the derby... You find teams out for redress.
"I saw the match between Arsenal and Newcastle. Playing at Newcastle's home is not easy, but it was an open and fascinating match.
"We will find a team that lost two-and-a-half days ago, they will want to play a great game at San Siro."
Inter lost the Derby della Madonnina 2-1 to Milan in September, but have since gone on to win seven of their eight games in all competitions.
Inzaghi's side are just ahead of Arsenal in the Champions League table, with both teams picking up seven points from their opening three games.
The two sides have only met previously in the 2003-04 Champions League – both games were away wins (Arsenal 0-3 Inter, Inter 1-5 Arsenal).
While history favours the visiting side, Inzaghi has said his side will try to dominate possession against Arsenal in order to remain unbeaten in the competition.
"If you see Arsenal among 100 teams, without knowing the name, you recognise them. They played for the last two English titles, point for point with Manchester City," he said.
"We will have to try to keep the ball as much as possible, we know that we are facing a team that put on a lot of offensive pressure.
"We know that it will be a problem for us when they have the ball but the opposite is also true."
Arsenal have also struggled in recent games in the Champions League in Italy, failing to find the back of the net in their last four away games in the country.
Emmanuel Adebayor was the last Gunners player to score there in a 2-0 win over Milan in March 2008, and Inter will be confident of keeping it that way.
Although only five teams have faced more shots in the Champions League this season than Inter (53), they have kept three clean sheets so far.
Neymar suffers fresh injury blow
Neymar sustained a new injury as he was forced off during Al-Hilal's AFC Champions League Elite win over Esteghlal.
Aleksandar Mitrovic plundered a hat-trick on Monday to seal a 3-0 win.
But Al-Hilal's victory was soured by an injury to Neymar, who had to make way just 29 minutes after he came on as a second-half substitute.
The Brazilian, who has just returned from over a year out of action following a serious knee injury, was forced off with what appeared to be a thigh issue.
Indeed, Monday's appearance was only the 32-year-old's second for Al-Hilal since his comeback.
He has featured just seven times for the Saudi Pro League champions in all competitions since his big-money move from Paris Saint-Germain in 2023.
Juve must play at their limits against in-form Lille, warns Motta
Thiago Motta stressed the importance of Juventus playing at their very best when they face Lille in the Champions League on Tuesday.
Juve face a tough task against a side who have already upset Real Madrid and Atletico Madrid in this season's competition.
This will be the first ever meeting between these teams.
However, Juve have lost three of their last four Champions League matches against French opponents (W1), including both against Paris Saint-Germain in the 2022-23 campaign. and Motta warned against any complacency.
"All matches are important. We, as Juventus, always want to win. The most important thing is always trying to improve," Motta told reporters on Monday.
"Lille are very confident, and we want to face them in optimal condition. We aim to give more than our maximum.
"There are no favourites in a match. It's a beautiful game, in a beautiful stadium, and we hope the pitch will be in good condition tomorrow. We can only talk tomorrow about who played better."
Motta will have midfielder Douglas Luiz from injury, but is still without a glut of players.
"He's [Luiz] one more player who can help the team. We’ll be missing Arek [Arkadiusz Milik], Gleison [Bremer] and [Nicolas Gonzalez]."
Lille boss Bruno Genesio knows Juve will present a stern test for his team, despite their shock wins over the Madrid clubs this term.
"Every Champions League match is different, but there is one essential parameter to get a result - commitment," he said.
"Like all Italian teams, Juventus are very well organised, very difficult to play against. Having already achieved two big results in this competition, we are going to give it our all again and we have our fans who will give us strength."
Jonathan David will be one of the standout Lille players Juve have to keep a close eye on.
The Canada international has scored six goals in his last eight Champions League appearances for Lille.
Lille have won all five games he has scored in but have not won any of the six games he has featured in without scoring (D2 L4).
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