Champions League holders Chelsea get their knockout campaign started on Tuesday as the defence of their crown enters an altogether more challenging stage.
Thomas Tuchel's men may feel they have dodged a bullet or two by getting this draw, with their next opponents Lille struggling to match the highs of their Ligue 1 title victory from last season in 2021-22.
Tuesday's other encounter sees Juventus travel to Villarreal, with Massimiliano Allegri looking to improve on the knockout exploits of Maurizio Sarri and Andrea Pirlo before him.
Here, Stats Perform delves into the Opta data to pick out the key statistical narratives and subplots ahead of Tuesday's games.
Chelsea v Lille
Much of the attention at Stamford Bridge will be on Romelu Lukaku, whether the Belgian plays or not.
The big-money signing's struggles this season have been well-publicised, but he hit a new low on Saturday as he touched the ball just seven times in the win over Crystal Palace – that is the fewest by any player to feature for 90 minutes in a single Premier League game since at least 2003-04.
On the other side of the contest is a striker aiming to emulate Lionel Messi. Jonathan David may not have scored a Ligue 1 goal since December but the talented Canadian impressed in the second half of the group stage.
He scored one goal in each of his last three appearances in the competitions, meaning if he scores on Tuesday he will be the second-youngest (22 years, 39 days) non-European to score in four successive Champions League games after Messi (21y, 155d in November 2008).
That is not to say Lille are a high-scoring side. Many will be wondering who let Les Dogues out of Group G, given their haul of seven makes them the lowest-scoring group winners since Leicester City and Atletico Madrid (seven each) in 2016-17. In fact, no team from that section scored more than eight.
The omens are, perhaps unsurprisingly, overwhelmingly in Chelsea's favour here. Only Manchester City (15) and Bayern Munich (14) have won more Champions League games than the holders since the start of last season, while Lille are appearing at this stage for just the second time ever.
Further to that, Tuchel boasts a fine record in Champions League knockout ties, having progressed from/won (including finals) eight of his previous 11 (73 per cent), a success rate bettered by only three managers (minimum 10 knockout ties): Vicente del Bosque (80 per cent - 8/10), Jupp Heynckes (86 per cent - 12/14) and Zinedine Zidane (88 per cent - 14/16).
Villarreal v Juventus
Sarri and then Pirlo were both tasked with establishing a new era at Juventus, but when Allegri returned after a two-year break in pre-season, he picked up the pieces of a side that had regressed significantly.
There remain plenty who feel Allegri never should have been re-hired, but this tie at least gives him an opportunity to point to a degree of progress – at least in the context of the Champions League.
After all, neither Sarri nor Pirlo got beyond the last 16. Allegri, on the other hand, was only eliminated at this stage once in five seasons, and that was to Pep Guardiola's excellent Bayern side.
His counterpart on Tuesday, Unai Emery, has something of a point to prove as well, but his has more to do with his own personal record.
While something of a specialist at Europa League level, having won the competition four times including last season, he has won only one of six knockout games in the Champions League.
Much of Emery's hope will be pinned on Arnaut Danjuma.
The Dutchman – who recently returned from two months out and scored a hat-trick at the weekend – had a hand in five goals in the group stage, which is already a joint-club record for the club in the competition.
By no means are the Yellow Submarine a one-man team, however. Young winger Yeremi Pino caught the eye in the group and is plotting to become only the fourth Spanish teenager to score in the knockout stages of the Champions League after Bojan, Cesc Fabregas and Raul.
Napoli 2-1 Parma: Lukaku and Anguissa fire Conte's men to last-gasp win
Romelu Lukaku and Andre-Frank Zambo Anguissa scored in second-half stoppage time as Napoli fought back for a thrilling 2-1 victory over Parma in Serie A.
Newly promoted Parma, who stunned Milan last week, looked set to claim a second surprise win in as many games when Ange-Yoan Bonny won and converted a 19th-minute penalty.
The momentum of the game changed, however, when Parma goalkeeper Zion Suzuki was shown his second yellow card for a foul on David Neres with 15 minutes of the 90 remaining.
With no further substitutions available to the visitors, defender Enrico Del Prato took over in goal and went close to getting his team over the line with a clean sheet intact.
However, new signing Lukaku came off the bench to equalise for Napoli in the second minute of stoppage time, shortly after the Partenopei had seen a penalty overturned following a VAR review.
There was more drama to come at the death as Anguissa headed home in the sixth minute of stoppage time, though Napoli also had to survive one last scare as Pontus Almqvist was denied by Alex Meret at the other end.
Data Debrief: Flying start for Lukaku
Just as Napoli's hopes seemed to be slipping away, up stepped debutant Lukaku to level with a low strike, setting the stage for the most remarkable of comeback victories.
Across the last five Serie A campaigns, Lukaku has 29 goals in 48 home games for Inter, Roma and Napoli. That is the fewest home games required by any player to net over 25 goals in the competition during that span.
Parma, meanwhile, were left to rue the sending-off of Suzuki, who became their first goalkeeper to see red in Serie A since Antonio Mirante against Sassuolo, back in March 2015.
Bayer Leverkusen 2-3 Leipzig: Visitors fightback halts unbeaten streak for Alonso's side
Bayer Leverkusen suffered their first defeat in 36 Bundesliga matches, as Leipzig came from behind to stun Xabi Alonso's side 3-2 at BayArena.
Lois Openda struck twice for Marco Rose's, who recovered from 2-0 down to make it two wins from two and move to the summit of the table.
It looked like business as usual for the reigning Bundesliga champions when they scored twice in the last seven minutes of the first half through Jeremie Frimpong and Alejandro Grimaldo.
However, Leipzig replied deep into first-half stoppage time with Kevin Kampl reducing the deficit.
Openda then brought the visitors level in the 57th minute, before a stunning long-range strike completed the turnaround 10 minutes from time, condemning Leverkusen to their first league defeat in 15 months.
Data Debrief: Leverkusen's long streak comes to a shuddering halt
Leipzig became the first side to beat Leverkusen in a Bundesliga match since Bochum achieved the feat a staggering 462 days earlier.
The visitors have begun a Bundesliga season with two wins from two for only the second time, also doing so in 2019-20.
They are also now unbeaten in 13 league matches, their longest such streak since Rose took charge.
As for Leverkusen, their invincible streak is officially history, as is their 29-game unbeaten run on home soil.
'We really let ourselves down' - Coleman slams Everton after late Bournemouth collapse
Seamus Coleman acknowledged Everton "really let ourselves down" and must "look at ourselves in the mirror" following their spectacular late collapse against Bournemouth.
Sean Dyche's side, who were seeking their first points of the season, led 2-0 in the 87th minute at Goodison Park through goals from Michael Keane and Dominic Calvert-Lewin.
However, the hosts were undone by three crosses in the latter stages, with Antoine Semenyo pulling a goal back and Lewis Cook levelling, before Luis Sinisterra completed a sensational turnaround in the sixth minute of stoppage time.
Boos rung around Goodison Park as the Toffees remained pointless and rooted to the foot of the Premier League table, and Coleman echoed the supporters' frustrations.
"We really let ourselves down in front of our fans," the skipper said. "We cannot take our foot off the gas at this level. Unfortunately, we did that.
"We cannot be conceding the goals that we did. We have to look at ourselves in the mirror."
Meanwhile, Dyche bemoaned the lack of responsibility amongst his players, as they became the first side in Premier League history to lose a game after leading by two or more goals in the 87th minute.
"We did so much right until they scored their first goal," the Everton head coach said. "The game should have been out of sight. We conceded one and then threw it away. I can't put my finger on it right now.
"They kept raining it forward and got their reward in the end. They were playing it forward and crossing it into the box, and we didn't deal with it. Simple stuff, but we threw it away. It is the third game we have thrown away this season.
"Everyone was looking at someone else to deal with things and that is when there is trouble. You could see the body language change. You have to see games through, and we have enough experience to do that, but today we didn't."
Bournemouth boss Andoni Iraola added: "It was the worst game we played this season. Everton deserved to win today, but the players kept pushing.
"I always have hope because this team has spirit. We have done it before and had some good comebacks. The spark of the first goal made us believe we could do it again."
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