Emile Smith Rowe and Harry Wilson were on target in either half as Fulham triumphed 2-0 over 10-man Crystal Palace at Selhurst Park.
Smith Rowe broke the deadlock in first-half stoppage time, taking Raul Jimenez's pass into his stride before finishing past Dean Henderson.
Fulham forward Smith Rowe had another goal ruled out in the second half for offside, before Daichi Kamada's 76th-minute red card for a poor challenge on Kenny Tete made matters worse for the hosts.
Wilson, the two-goal hero against Brentford on Monday, made sure of all three points with seven minutes remaining, latching onto Alex Iwobi's superb throughball and slotting home.
The Wales international saw another late strike overturned for handball, but another London derby victory moved Marco Silva's side up to sixth place and saw them join a cluster of sides on 18 points.
Meanwhile, Palace's sixth league defeat of the season leaves them 17th and just a point clear of the relegation zone heading into the international break.
Data Debrief: Cottagers extend streak as super sub Wilson strikes again
Fulham have now kept a clean sheet in each of their last four away league games against Palace, not going longer without conceding against a single opponent on the road.
Now unbeaten in seven Premier League London derbies, the Cottagers are now on their joint-longest run without defeat in such matches.
Wilson sealed the victory with his third goal as a substitute in the space of a week. Only Collins John (four) has netted more times as a substitute for Fulham in a single season than the Wales international.
A difficult day for Palace was worsened by Kamada's dismissal. Three of the Eagles' last six Premier League red cards have come against the Cottagers, against no other side have they seen more.