Premier League leaders Manchester City collected a routine victory over Brentford to further their advantage at the top.
That victory saw Pep Guardiola's side extend their lead at the summit to 12 points, with second-placed Liverpool due to host Leicester City on Thursday.
Tottenham fell to a late defeat against Southampton as Antonio Conte suffered his first home league loss as Spurs boss, while Aston Villa shared the spoils in a six-goal thriller with Leeds United.
And strugglers Norwich City picked up a valuable draw at home to Crystal Palace, with Dean Smith's side now a point behind 17th-placed Newcastle United as the relegation battle continues.
Here, Stats Perform unpacks the pick of the Opta data from the day's top-flight action.
Manchester City 2-0 Brentford: Citizens cruise to league double over Bees
Strikes either side of the interval from Kevin De Bruyne and Riyad Mahrez helped City to a 2-0 win over Brentford as the Citizens completed the league double over the Bees for the first time since 1936-37.
Mahrez opened the scoring as he netted in his seventh consecutive game across all competitions for City – only Lionel Messi (twice) and Sergio Aguero have previously achieved that feat under Pep Guardiola.
De Bruyne doubled the hosts' lead in the second half, the midfielder recording his 85th goal involvement (35G 50A) in his 96th top-flight appearance at the Etihad Stadium, where he has found the net five times in his last four games.
Brentford rarely troubled Ederson's goal and were caught offside 10 times in the match, the most by a Premier League team since January 2018 as City recorded their 100th clean sheet under Guardiola in the competition.
The Bees have now lost five consecutive league matches for the first time since December 2007, under Terry Butcher in League Two, and for the first time in the top flight since April 1947 (seven in a row).
Tottenham 2-3 Southampton: No home comforts for Conte
Southampton twice rallied from behind to earn a late 3-2 victory at Tottenham to end Conte's unbeaten start at home in the league as Spurs boss.
Jan Bednarek poked into his own net to give Spurs the lead, the centre-back now on a Premier League-high three own goals since the start of 2019-20. Similarly, Tottenham have benefited from the most own goals in the competition this season (three).
But Armando Broja soon levelled up. That was the Albania striker's sixth top-flight goal this term – only Kevin Davies (nine in 1997-98) managed more in the Premier League for Southampton while aged 20 or under.
Son Heung-min restored his side's advantage with his 12th strike against Southampton across all competitions, five more than he has registered against any other team for Spurs.
Saints fought back again, Mohamed Elyounoussi equalising before Che Adams sealed victory. Both finishes were set up by James Ward-Prowse, who assisted two goals in a single Premier League match for only the second time in 290 appearances.
Having equalised in the 79th minute, Southampton's victory was the latest they had been behind in a Premier League match that they would go on to win since March 2016 against Liverpool (equalised in 83rd minute).
Aston Villa 3-3 Leeds United: Whites continue away scoring run in Villa Park classic
Aston Villa, who had Ezri Konsa dismissed late on, shared the points with Leeds in a 3-3 thriller as Dan James, Jacob Ramsey and Philippe Coutinho dominated proceedings.
James scored his third and fourth Premier League goals this term, his best-ever tally in a season, though Marcelo Bielsa found his side 3-2 down at half-time.
Coutinho initially cancelled out James' opener as he became the sixth Villa player to score in each of his first two Premier League appearances at Villa Park, and the first since Carlton Cole in August 2004.
The Brazil international then teed up a Ramsey double as the midfielder became the youngest player to score more than one goal in a Premier League game for Villa (20y 257d) since Luka Moore got a hat-trick in February 2006 (19y 356d).
Diego Llorente restored parity in the second half as Leeds recorded three goals in consecutive Premier League away games for just the second time, and for the first time since March 1995, to earn a valuable point.
Norwich City 1-1 Crystal Palace: Zaha's penalty falter costs poor travelling Eagles
Norwich City raced out the blocks at Carrow Road but ultimately had to settle for a point after a 1-1 draw with Crystal Palace.
Teemu Pukki – who has scored 43 per cent of Norwich's top-flight this season (6/14), the highest such share of any player in the competition – netted the fastest goal in the Premier League this season as he finished after just 38 seconds.
Wilfried Zaha pegged Smith's team back with his 80th goal involvement in England's top division (53G 27A), 79 of which have been for the Eagles.
Michael Olise teed up the Ivory Coast international's second-half equaliser, his seventh goal involvement (3G 4A) across all competitions in 2022 – the most by any Premier League player.
Palace should have secured all three points but Zaha failed from the penalty spot for the first time, on his fifth attempt, meaning the Eagles have won just one of their last 13 away games in the league.
Sessegnon rejoins boyhood club Fulham after Tottenham departure
Ryan Sessegnon has resigned for Fulham on a free transfer, five years after leaving the club.
The 24-year-old signed a two-year contract with the Cottagers with the option to extend for a further year following his departure from Tottenham last month.
In his first spell at the club, Sessegnon worked his way through the academy over 11 years, scoring 25 goals in 120 first-team appearances.
He then moved to Spurs in a £25million deal in 2019, though struggled to nail down a place in North London, making just 57 appearances in all competitions, and scoring three goals.
"It's amazing to be back. Emotional, as well," he told FFCtv. "It's where it started for me, where everything began, and it's amazing to be back.
"It will always be home for me. I think it had the feeling that it was meant to be, coming back here, so I'm delighted to get it done."
Sessegnon is Fulham's first signing of the transfer window, though they have seen plenty of first-team departures already, with Joao Palhinha, Tosin Adarabioyo and Bobby De Cordova-Reid all leaving the club.
Ederson slams reports of rift with Man City backup Ortega
Ederson has hit out at reports of a rift between himself and fellow Manchester City goalkeeper Stefan Ortega.
The Brazilian was substituted after suffering a fractured eye socket in City's penultimate game of the Premier League season, a vital 1-0 win over Tottenham.
Ortega replaced him and made a brilliant save to deny Son Heung-min as City maintained their slender lead over Arsenal at the top of the table, sealing an unprecedented fourth straight title by beating West Ham five days later.
Ortega was widely lauded for his role in that triumph, and an article published by The Athletic this week suggested Ederson took issue with that praise.
However, the goalkeeper – who missed the Copa America as a result of his injury – has now moved to shut down those suggestions with a post to his Instagram story.
"I would like to clarify that the note published by The Athletic yesterday, referring to my alleged dissatisfaction with a co-worker, is completely false," he wrote.
"The alleged day reported was, without a doubt, one of the most difficult days of my career, when I suffered a fracture that prevented me from playing in the final stretch of the season and, consequently, from representing my country in the Copa America.
"At the time of the injury, my only thought was to continue in the match, defending City in the fight for the title.
"But the emotion of the match would be greater than the reality and, inevitably, I would not be able to continue as I would have liked due to the damage it caused, completely blocking my field of vision. I remain focused on preparing for the season."
Ederson has been linked with a transfer in recent days, reportedly attracting interest from Saudi Pro League clubs.
Postecoglou urges Tottenham fans to be patient amid transfer 'misinformation'
Ange Postecoglou has urged Tottenham fans to have patience when it comes to bringing new players in during the transfer window.
Spurs have signed just two new faces so far, with Archie Gray joining from Leeds United in a deal reportedly worth up to £40million, and Lucas Bergvall signing from Djurgardens.
Alongside the two 18-year-olds, Timo Werner has also been resigned on loan for the upcoming season. He enjoyed an impressive start after initially joining in January, as he contributed two goals and three assists, but his season was ended prematurely by injury.
While the Spurs faithful are keen for their club to bring more reinforcements, Postecoglou asked for their trust as the club works towards adding to the squad.
"At this time of year, it's pretty hard for supporters because they don't have all the information, and it's fair to say there's plenty of misinformation out there," he said in a press conference.
"We're working hard to bring players in, and it's a process that you sometimes have to be patient with. But in terms of what we set out to do, that's still the plan, and you have to stay disciplined with that.
"Sometimes the timings don’t work out, and it doesn’t happen as quickly as you want, and you don't get them [players] in at the right time, but I think it's really important you stay disciplined and not run off and chase other things.
"So, what we started with at the start of summer is still there, and I wouldn't want to put timelines on it. A lot of that is out of our control, and we just need to be patient.
"From where I sit, at the moment, we're still in that phase where what we identified is still what we're after."
Spurs will face Japanese side Vissel Kobe in their next pre-season match on Saturday.
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