Cameroon were hot favourites to book a quarter-final place even before Comoros revealed they must field an outfield player in goal for Monday's Africa Cup of Nations last-16 clash.
Now hosts Cameroon must keep their focus in the unusual circumstances, while tournament debutants Comoros surely need a footballing miracle.
That is Monday's second knockout game, and it comes after a tussle between Guinea and Gambia in Bafoussam.
Guinea v Gambia (16:00 GMT)
Guinea will be without Liverpool midfielder Naby Keita for this one, after he picked up a second yellow card of the tournament late on in the defeat to Zimbabwe last time out.
The clash at Kouekong Stadium is one between teams that finished second in their respective groups, and Gambia will hope their good fortune holds after arguably riding their luck to reach this point.
Tom Saintfiet's Gambia side have outperformed their expected goals (xG) total, scoring three times from an xG of 2.0, while conceding just once despite an expected goals against (xGA) tally of 4.7. The 3.7 gap between xGA and actual goals conceded was the highest of all teams in the group stage.
Gambia faced the most shots of all teams (58) in the group stage, but remarkably they still kept two clean sheets, including when they pulled off a shock 1-0 win over Tunisia.
Guinea underperformed in their shooting, scoring only twice from an xG of 4.0 across their three group fixtures.
Gambia coach Saintfiet said ahead of the game: "We are not afraid as we have been together with the players for over three years, meaning we have cohesion and great team spirit."
One to watch: Amadou Diawara (Guinea)
Guinea are looking to win their first knock-out match at the Africa Cup of Nations at the sixth attempt, having lost all five of their previous such attempts. Roma midfielder Diawara should be a key figure in their efforts to come through this one, bringing his plentiful Serie A experience to bear.
Cameroon v Comoros (19:00 GMT)
Considering Cameroon were the top scorers in the group stage with seven goals, Comoros would have liked their first-choice goalkeeper fit for this one. Second choice would have been fine, third choice a salvageable situation. But instead they are all out of keepers, with Salim Ben Boina injured and both Moyadh Ousseini and Ali Ahamada testing positive for COVID-19.
The minnows will hope their chosen emergency keeper proves a revelation at Stade d'Olembe, but the prospects for Comoros appear bleak, despite them reaching the knockout stages with a shock 3-2 win over Ghana.
This will be the first Africa Cup of Nations encounter between Cameroon and Comoros, who on Saturday reported a total of 12 COVID cases in their camp.
Cameroon have reached at least the quarter-finals in eight of their last 10 Africa Cup of Nations appearances, although they have failed to do so in two of the previous three editions (group stage in 2015 and last-16 in 2019).
No doubt licking his lips at the prospect of facing Comoros will be Cameroon captain Vincent Aboubakar, top scorer in the tournament with five goals in the group stage. The last players to score more than five goals in a single edition of the Africa Cup of Nations were Egypt's Hossam Hassan and South Africa's Benni McCarthy (both 7) in 1998.
One to watch: The rookie goalkeeper
Whoever gets the gloves faces a daunting challenge. Cameroon attempted 35 shots in the group stage, more than any other side, and also tried 63 crosses (only Senegal and Egypt had more). Comoros shipped five goals in three games when they had a recognised goalkeeper, losing two of their three Group B games. They should be ripe for being picked off by the home team in Yaounde.
Coventry City 2-3 Hull City: Tigers win five-goal thriller to keep play-off hopes alive
Hull City kept their hopes of gatecrashing the Championship play-offs alive with a thrilling 3-2 win over beaten FA Cup semi-finalists Coventry City on Wednesday.
Noah Ohio scored the winner with his first touch after coming on as a second-half substitute as Hull moved within three points of sixth-placed Norwich City with two games to play.
Coventry, meanwhile, saw their own hopes of returning to Wembley Stadium for a second successive play-off final all but ended, as they sit six points further back with three matches remaining.
Three days on from their remarkable comeback against Manchester United, the Sky Blues twice fought back to level things at Coventry Building Society Arena. Jaden Philogene's shot squirmed under goalkeeper Bradley Collins to put Hull ahead 31 minutes in, but Kasey Palmer levelled within five minutes with a stunning free-kick.
Hull went back ahead in controversial circumstances on the stroke of half-time, Liverpool loanee Fabio Carvalho converting from the penalty spot despite replays showing Joel Latibeaudiere's foul on Liam Delap took place outside the area.
Mark Robins' men again dragged themselves back into the game as Bobby Thomas headed Jay Dasilva's cross in just before the hour mark, but it was Liam Rosenior's visitors who found a winner.
Thomas went from hero to villain as his poor back pass sold Collins short, and Ohio got a toe to the ball to score the winner, keeping Hull's hopes of Premier League football intact.
Van Dijk: Liverpool have 'no chance' in title race after derby defeat
Virgil van Dijk conceded Liverpool might be out of the Premier League title race after they suffered a surprise 2-0 defeat to Everton in Wednesday's Merseyside derby.
Jarrad Branthwaite and Dominic Calvert-Lewin scored in either half to give the Toffees their first win over Liverpool at Goodison Park since 2010.
Liverpool struggled to find a way through the Toffees' defence despite dominating for long periods, and the Reds' captain says they will not outlast Arsenal and Manchester City without major improvements.
Speaking to Sky Sports, Van Dijk said: "If we play like today, then we have no chance to consider ourselves in the title race.
"We have to just focus on the next game and that will be a tough one anyway, so we will see.
"We're very disappointed, in so many ways. I think everyone has to look at their own performances. Did they really give everything, and do they really want to win the league?
"We're still fighting and there are still games after tonight, but if we play like we did overall in the game today – not winning challenges and giving the referee a chance to give free-kicks like he did many times, then you have no chance to win the title."
Howe: Newcastle performance in Palace defeat 'way off' Spurs win
Eddie Howe admitted Newcastle United's performance in the 2-0 loss at Crystal Palace on Wednesday was "way off" the one that saw them thump Tottenham in their previous game.
Howe's men hammered Spurs 4-0 in their last match, but they never got close to matching the attacking verve from that outing and a Jean-Philippe Mateta double condemned the Magpies to defeat at Selhurst Park.
Newcastle didn't even manage a shot on target until the 87th minute, accumulating just 0.42 xG (expected goals) as the likes of Alexander Isak and Anthony Gordon struggled to make an impact.
Only against Manchester City in August (one) have Newcastle recorded fewer shots on target in a Premier League game this season than their two against Palace, and Howe was critical of his team's display in the loss, one that all but ends their hopes of finishing in the top four.
"[It is a] bad day for us," Howe told Newcastle's club media.
"I thought we were disappointing today, especially in the first 60 minutes. We were way off our levels against Tottenham and our best levels.
"I thought technically we didn't deliver a good performance, and out of possession I don't think it was a particularly good performance either."
Newcastle were unlocked twice for Mateta to score by a Palace side who themselves only generated 0.88 xG.
Howe was left frustrated by the manner in which his side conceded, adding: "I think we'll be disappointed with our performance technically today, and that's probably epitomised by the two goals where we're disappointed with how we've given them the ball in those situations and then how we defended.
"I think the goals sum up aspects of our performance where there was some good, lots of moments that could have led to opportunities, but we were slow to shoot around the box," he said.
The defeat, combined with Manchester United's 4-2 win over Sheffield United, means Newcastle drop to seventh, while eighth-placed West Ham are two points behind with a game in hand.
Newcastle have now lost eight of their last 11 Premier League away games, while they have lost on four occasions in London in the league this term, only doing so more times in a Premier League season in 2000-01 and 2005-06 (both five).
It's been a disappointing season for Howe and his side, especially compared to the heroics of last term when Newcastle finished in the top four, and the Magpies boss knows there's work to be done to get back to those levels.
"It's a day that we have to take our punishment, deal with it, and then try and improve," Howe continued. "It's frustrating because we know we're capable of much better."
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