Cristiano Ronaldo has emerged as an injury doubt for the Premier League match between Manchester United and West Ham on Saturday.
The Portugal star played 71 minutes of the 3-1 win at Brentford on Wednesday before being substituted - a decision with which he was clearly annoyed.
Interim manager Ralf Rangnick insisted he had no problem with the player becoming frustrated at going off and that it would not affect his chances of facing the Hammers at Old Trafford.
However, Rangnick later confirmed Ronaldo suffered a neck injury during the victory over Brentford that could keep him out of the game.
"Cristiano is a question mark because he has a problem with his neck," he said to MUTV on Friday.
"He received treatment yesterday [Thursday] for two, three hours and we will have to wait to see how he feels today."
Edinson Cavani missed the match at Brentford Community Stadium and he too is facing a race to be fit for the visit of David Moyes' men.
"Edi hasn't been training with the team yet and will hopefully resume training today and then we'll take the final decision after the training session, [around] if he will be available for the game," Rangnick said.
Losing Ronaldo and Cavani presents United with a possible striker shortage given Anthony Martial is attempting to secure a move away from the club.
Rangnick left Martial out of the 2-2 draw at Aston Villa, saying the France international had told him he did not want to be involved – a claim Martial later disputed.
Jesse Lingard will be available to face the club for whom he excelled on loan last season, while Jadon Sancho, who missed the Brentford match due to a family funeral, could be involved.
"We need to see where Jadon stands," said Rangnick. "He didn't train yesterday. As you know, he attended a funeral on Wednesday and didn't want to train yesterday as he is still affected by that. We will have to see.
"I will see him for training today and speak with him after the training session, to see if he is in the state of mind, and also his energy [is there], so he can be available for tomorrow."
Aaron Wan-Bissaka will also be missing again with illness, while Victor Lindelof will sit out the game after a burglary of his family home, but midfielder Scott McTominay hopes to be involved after battling a back problem.
Ronaldo concedes he 'can't think long term anymore'
Cristiano Ronaldo has conceded he "can't think long term anymore" as he approaches his forties.
Ronaldo, who has scored the most goals in history, is still starring for Al-Nassr in Saudi Arabia, while he is a regular starter for Portugal under Roberto Martinez.
The former Real Madrid superstar turns 40 in February, though is showing no signs of slowing down and has already scored 10 goals for his club this season.
He also hit the 900-career goals mark when he netted for his country against Croatia in September, and has since added two more international strikes to his vast collection.
Ronaldo has publicly set out his aim to net 1,000 goals before he retires, but he knows short-term targets are now the order of the day in the twilight of his career.
"I now face my life as living in the moment. I can't think long term anymore," Ronaldo said after receiving the Platinum Quinas, the highest honour available to Portuguese players.
"I said that I wanted to reach 1,000 goals, but it seems that now everything is easy, just last month I reached 900.
"It's about living in the moment, seeing how my legs will respond in the next few years. If I reach 1,000 goals, that's fine, but if I don't, I'm already the player with the most goals in history."
FPF president Fernando Gomes hailed Ronaldo as "an ambassador for Portugal".
Ronaldo also took the chance to air his disappointment at players who chose not to represent Portugal.
He said: "I believe there is nothing better than representing the national team. Coming to play for the national team, and representing the entire country — all its culture, your children, your mother, your father, your best friends — that is why I often feel disappointed with some players who do not want to represent the national team.
"Time flies, and there is nothing better than playing. I hear many people say that Portugal is a small country. Portugal is a great country. We need to think that way; we must believe that, regardless of the country's size, we have everything: an extraordinary country, the infrastructures we have, the stadiums, the magnificent coaches we have.
"The potential of these players, the stars we have, we just need to refine a few edges and believe that one day we will be great."
Ronaldo's Portugal host Poland in the Nations League on Friday before taking on Croatia three days later.
'Legend' Van Nistelrooy departs Man Utd after Amorim arrival
Manchester United have confirmed Ruud van Nistelrooy has departed the club following Ruben Amorim's arrival at Old Trafford.
Van Nistelrooy returned to the club in July on a two-year contract as an assistant to Erik ten Hag.
He was placed in interim charge after Erik ten Hag's dismissal last month.
The 48-year-old oversaw four games during his temporary tenure, earning victories over Leicester City in the EFL Cup and PAOK in the Europa League. United were then held to a 1-1 draw by Chelsea, but Van Nistelrooy signed off in style with a 3-0 win over the Foxes in the Premier League on Sunday.
But Amorim, who began his new role on Monday, has decided against retaining the Dutchman's services, with the club saying the full men's first team coaching composition will be announced in due course.
"Ruud is and always will be a Manchester United legend," the club said in a statement.
"We are grateful for his contribution and the way in which he approached his role throughout his time with the club. He will always be very welcome at Old Trafford."
Assistant Rene Hake, goalkeeping coach Jelle ten Rouwelaar and analyst Pieter Morel have also left the club.
However, former United midfielder Darren Fletcher will remain in his coaching role and continue his link between the first team and the academy.
Pereira replaces Amorim as Sporting head coach
Sporting CP have confirmed Joao Pereira as the club's new head coach following Ruben Amorim's departure to Manchester United.
Pereira, who made 154 appearances across three different spells with Sporting, has put pen to paper on a deal that runs through until 2027 with the Primeira Liga champions.
The 40-year-old also appeared five times under Amorim during the 2020-21 season, a campaign that saw Sporting claim their first top-flight title in 19 years.
Pereira has previously managed Sporting's Under-23 side, taking charge of 53 games and winning 20 of those (D17 L16), averaging 1.45 points per match.
He most recently took charge of Sporting's B team, but oversaw just 11 matches, and he is relishing the opportunity of leading the club after the international break.
"As a player, Sporting gave me a lot, allowing me to play for the national team, join one of the best leagues in the world and return home twice," Pereira said.
"I only repaid them with a Super Cup and a national championship, which felt more like their gift to me.
"That’s something I regret, so as a coach I’d like to repay them with more titles because Sporting deserve it.
"If I had doubts and thought things might go wrong, I wouldn’t be here. It hasn’t even crossed my mind that it could go poorly.
"I know we’ll face challenges, but I believe it will go well."
But Pereira has a tough act to follow, with Amorim ending his glittering stint with the club on a high after a 4-2 win over Braga on Sunday.
Amorim won 164 of his 231 games in charge of Sporting, averaging a win percentage of 71%, which is a club record.
During his time in charge, only Manchester City (127) won more matches than his Sporting team (122) across Europe's top 10 leagues.
"Ruben leaves behind a legacy, and that legacy isn’t only in titles, victories, and records but also in the unity he built among the Sporting family," Pereira added.
"I know this brings great responsibility, but that responsibility comes hand-in-hand with a strong ambition and motivation to continue making Sporting a winning club with a bright future.”
Pereira's first assignment will come in the Taca de Portugal against fourth-tier side Amarante on November 22, before welcoming Arsenal to the Estadio Jose Alvalade in the Champions League five days later.
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