Phil Jones will make his first Premier League start in two years for Manchester United, while Bruno Fernandes was left on the bench for the visit of Wolves.
Jones last started a top-flight game against Burnley in January 2020 but injury issues with Harry Maguire and Eric Bailly, along with COVID-19 complications for Victor Lindelof, have left United short-handed in defence.
The 712 days between games for Jones is the longest gap any player who has not left the club - including loan spells - has had between appearances for the Red Devils in the competition.
The former Blackburn defender, who missed the entire 2020-21 season, has been an unused substitute in five league games this campaign, though he will join Raphael Varane at the back on Monday.
Further forward, Jadon Sancho and Mason Greenwood will operate in behind Cristiano Ronaldo and Edinson Cavani, meaning Fernandes is left among the substitutes for the clash with Bruno Lage's side.
The Portugal international was absent from the 3-1 win over Burnley last Thursday due to suspension, after he and compatriot Ronaldo came into criticism from Sky pundit Gary Neville for their body language during a disappointing 1-1 draw at Newcastle.
Fernandes was an integral figure in propelling United to Champions League qualification last campaign as he netted 28 times in all competitions.
That was the best return by a midfielder for a Premier League club in a single campaign, surpassing Frank Lampard's 27 for Chelsea in 2009-10, but he has failed to hit those lofty heights this term with five top-flight goals to his name so far.
Wolves make two changes as Francisco Trincao and Nelson Semedo come into the starting line-up, while Adama Traore starts on the bench for the visitors.
TEAMS
Manchester United: David de Gea, Aaron Wan-Bissaka, Raphael Varane, Phil Jones, Luke Shaw, Scott McTominay, Nemanja Matic, Mason Greenwood, Jadon Sancho, Edinson Cavani, Cristiano Ronaldo. Subs: Marcus Rashford, Jesse Lingard, Fred, Bruno Fernandes, Diogo Dalot, Dean Henderson, Alex Telles, Donny van de Beek, Anthony Elanga.
Wolves: Jose Sa, Max Kilman, Conor Coady, Romain Saiss, Nelson Semedo, Ruben Neves, Joao Moutinho, Marcal, Francisco Trincao, Raul Jimenez, Daniel Podence. Subs: Ki-Jana Hoever, Rayan Ait Nouri, Bruno Jordao, Fabio Silva, John Ruddy, Leander Dendoncker, Adama Traore, Luke Cundle, Hugo Bueno.
'There are no gimmies' – Dyche warns Everton not to step off the pedal
Everton's big win over Liverpool shows they are "sticking to the task", so says Sean Dyche, who knows his team must keep their feet on the ground as they aim to overcome Brentford.
The Toffees won 2-0 at Goodison Park on Wednesday, taking a huge stride towards Premier League safety and denting their rivals' title hopes in the process.
Everton moved onto 33 points, eight clear of 18th-placed Luton Town with four games remaining.
It means that, should Luton fail to beat Wolves on Saturday, Everton - who face Brentford at home in an evening kick-off - would be able to ensure their safety with a victory.
Dyche, though, is taking nothing for granted.
Reflecting on the derby victory, Dyche said: "Well, it certainly says we're sticking to task, whatever comes at us. I'm certainly proud of that, because we've had some ups and downs ourselves.
"But it has to be parked because another one is coming around. Another important game, another chance, another opportunity to play at Goodison and get three points, so there is a lot on the next game. So they do have to have a window to enjoy that last night.
"That's the challenge. Of course, I said enjoy the moment, but I said let's go and do it again.
"It's a decent outfit in Brentford. They had a funny spell themselves and have come out of that.
"It's not easy. There are no 'gimmies' in this league. I praised the players first last night and then said 'Right, tomorrow we come in and get on with business'.
"We've taken big steps, but there are more to come. We can control the situation ourselves, and that's what we have always aimed to do - even with the points taken away and all that sort of stuff. Grip hold of it and let's run with it and I think we're beginning to show that again. Three wins out of four now: three home wins, clean sheets, good signs."
Brentford boss Thomas Frank said: "It's been a tough season - everyone is in the Premier League, no matter where you are in the table. But this season in particular because of injuries and other things that have been happening."
PLAYERS TO WATCH
Everton - Dominic Calvert-Lewin
Calvert-Lewin was immense against Liverpool, scoring for the third time in four Premier League appearances. The striker netted in Everton's 3-1 win over Brentford in the reverse fixture in September.
Brentford - Bryan Mbeumo
Mbeumo has been involved in nine goals in his last 10 Premier League starts, while Brentford have won 39 per cent of their league games when the Cameroonian has started this season (7/18), compared to 12.5% when he has not (2/16).
MATCH PREDICTION: DRAW
Brentford have scored eight goals in their last two Premier League away games, netting five on the road for the first time ever in the top flight last time out at Luton.
Everton have opened the scoring in each of their last four Premier League meetings with Brentford, doing so in the opening 10 minutes of the match on three occasions in that run.
None of the 10 league meetings between Everton and Brentford at Goodison Park have ended in a draw, with the Toffees winning seven of these to the Bees' three. However, the Opta supercomputer is predicting a draw is a likely result.
Having been unbeaten in their first three Premier League games against Everton (W2 D1), Brentford have now lost their last two against the Toffees.
OPTA WIN PROBABILITY
Everton - 32.4%
Brentford - 38.2%
Draw - 29.4%
Man Utd matchwinner Fernandes: Criticism part of the job
Bruno Fernandes said Manchester United's players cannot afford to get annoyed by outside criticism, after he scored twice to fire the Red Devils to a much-needed win over Sheffield United.
Erik ten Hag's team were roundly criticised for their performance in Sunday's FA Cup semi-final against Coventry City, as they surrendered a 3-0 lead to draw 3-3 before inching through in a penalty shoot-out.
They had also gone four Premier League games without a win (three draws, one defeat) prior to Wednesday's meeting with the rock-bottom Blades, with their hopes of Champions League football all-but over.
They twice trailed as Sheffield United threatened a huge upset, but Fernandes scored twice and supplied an assist as they fought back to claim a 4-2 win.
Asked whether the noise around Sunday's semi-final win had affected the mood at Old Trafford, Fernandes told Sky Sports: "That's part of the job.
"You can be in a run of games where you win eight or nine in a row, and when you lose one you know you'll be criticised.
"Being at Manchester United demands winning every game, so it's part of the job. If there is anyone in the dressing room still not used to that, they will get used to it!
"Being a Manchester United player demands being ready to receive as much criticism as praise. We receive praise when we do good things so we can't be annoyed by the criticism.
"When people want to do that, they might have a point. We can think in a different way, but we have to take it in the same way as we take the credit they give us."
Ten Hag's team did look disjointed for long periods on Wednesday, though, and they have now conceded 50 Premier League goals this season.
The Red Devils have now shipped a half-century of goals in two of their last three Premier League campaigns, having done so just once in their previous 29.
Ten Hag, though, was content with most aspects of their performance, saying: "It was a good game for the crowd, they saw four goals and many chances that we created.
"I think we played quite well, we created many more chances, so there's many positives. But also negatives. Conceding two goals from giveaways, that's unacceptable.
"We want to play dynamic, attacking football. That is what we want to see. Since the winter we have created lots of chances and also scored a lot of those chances."
Premier League record falls as 2023-24 becomes most goal-laden 20-team season
The current Premier League season has become the most goal-laden 20-team campaign in the competition's history, with Harry Maguire the unlikely man to seal 2023-24's place in history.
Maguire scored Manchester United's first equaliser as they twice fought from behind to clinch a 4-2 win over Sheffield United on Wednesday, with Bruno Fernandes netting twice in the second half.
The centre-back's 42nd-minute header was a significant moment, representing the 1,085th goal scored in the Premier League this term.
That is the most ever scored in a season containing 20 teams, since 1995-96.
The 2022-23 season saw 1,084 goals scored, a tally that was reached on the final day to surpass the previous 20-team record of 1,072, set in 2018-19.
It was somewhat fitting for the record-breaking goal to be conceded by Sheffield United, who have certainly played their part in making 2023-24 the most goal-laden season to date.
The Blades have now shipped 92 goals this term, the most ever conceded in a 38-game Premier League campaign.
With four games to come, including a rematch with a Newcastle United team that thrashed them 8-0 earlier this campaign, the prospect of Chris Wilder's men bringing up triple figures is a realistic one.
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