Phil Jones will make his first Premier League start in two years for Manchester United, while Bruno Fernandes was left on the bench for the visit of Wolves.
Jones last started a top-flight game against Burnley in January 2020 but injury issues with Harry Maguire and Eric Bailly, along with COVID-19 complications for Victor Lindelof, have left United short-handed in defence.
The 712 days between games for Jones is the longest gap any player who has not left the club - including loan spells - has had between appearances for the Red Devils in the competition.
The former Blackburn defender, who missed the entire 2020-21 season, has been an unused substitute in five league games this campaign, though he will join Raphael Varane at the back on Monday.
Further forward, Jadon Sancho and Mason Greenwood will operate in behind Cristiano Ronaldo and Edinson Cavani, meaning Fernandes is left among the substitutes for the clash with Bruno Lage's side.
The Portugal international was absent from the 3-1 win over Burnley last Thursday due to suspension, after he and compatriot Ronaldo came into criticism from Sky pundit Gary Neville for their body language during a disappointing 1-1 draw at Newcastle.
Fernandes was an integral figure in propelling United to Champions League qualification last campaign as he netted 28 times in all competitions.
That was the best return by a midfielder for a Premier League club in a single campaign, surpassing Frank Lampard's 27 for Chelsea in 2009-10, but he has failed to hit those lofty heights this term with five top-flight goals to his name so far.
Wolves make two changes as Francisco Trincao and Nelson Semedo come into the starting line-up, while Adama Traore starts on the bench for the visitors.
TEAMS
Manchester United: David de Gea, Aaron Wan-Bissaka, Raphael Varane, Phil Jones, Luke Shaw, Scott McTominay, Nemanja Matic, Mason Greenwood, Jadon Sancho, Edinson Cavani, Cristiano Ronaldo. Subs: Marcus Rashford, Jesse Lingard, Fred, Bruno Fernandes, Diogo Dalot, Dean Henderson, Alex Telles, Donny van de Beek, Anthony Elanga.
Wolves: Jose Sa, Max Kilman, Conor Coady, Romain Saiss, Nelson Semedo, Ruben Neves, Joao Moutinho, Marcal, Francisco Trincao, Raul Jimenez, Daniel Podence. Subs: Ki-Jana Hoever, Rayan Ait Nouri, Bruno Jordao, Fabio Silva, John Ruddy, Leander Dendoncker, Adama Traore, Luke Cundle, Hugo Bueno.
Leicester's Fatawu ruled out for rest of season with ACL injury
Leicester City manager Steve Cooper confirmed Abdul Fatawu will miss the rest of the season.
The 20-year-old sustained an anterior cruciate ligament injury (ACL) while playing for Ghana against Angola during the international break.
Fatawu has featured in all 11 of Leicester's Premier League matches so far this season and has registered two assists.
No Leicester player has attempted (61) or completed (29) more dribbles than him, while his 30 crosses is also a team-high in the top-flight this season.
"It's not good, it's a serious injury," said Cooper ahead of their match against Chelsea on Saturday.
"It's a real blow, first and foremost for him, being a young player and having an injury as serious as what an ACL is.
"Albeit, it can be quite common in sport, and in particular football, but it's still a serious injury.
"For it to happen at a young age is a blow for him and a blow for us as well.
"He's obviously a big talent and a young player, as exciting as he can be at his age, with lots to learn.
"It's only a pause, and we will make sure, as difficult as it is at the moment for him, that he comes back being a stronger player and person, which, with the mentality and character that he has, I think will be the case."
Arsenal qualifying for Champions League quarter-finals feels 'surreal', says Slegers
Renee Slegers says it feels "surreal" that Arsenal have secured their place in the Champions League quarter-finals with two games to spare.
The Gunners will finish at least second in Group C after Lina Hurtig's late strike secured a 1-0 win over Juventus on Thursday.
What looked to be a frustrating encounter was turned around by Slegers' substitutions, and after missing a glorious chance, Hurtig was eventually the difference at the Emirates.
Arsenal created 3.69 expected goals (xG) from their nine shots, getting three on target, compared to just 0.5 for Juventus, who tested Daphne van Domselaar the same amount of times.
Slegers was impressed by her side's resilience as they pushed to come away with all three points.
"It's surreal to be honest," Slegers said post-match. "I never felt we would get into this situation. We have done really well.
"I was part of Jonas [Eidevall's] staff and there was so much that was built during his time. I don't want to separate that. There is so much we are still building on. It's surreal in so many ways but we are very happy.
"I'm just happy for the team to win. Obviously, we have amazing depth in the squad, and we know anyone can do it for us - whether it's starting players or finishing players.
"It's the visualisation of how much everyone contributes in the team. I think that's what it means for us."
Slegers took over as interim manager following Jonas Eidevall's departure last month and has gone unbeaten in her first seven games, winning six and drawing one.
They have won each of their last five in all competitions, and have not conceded a goal in their previous four matches.
"It was just a very impressive block of the team," Slegers said. "We conceded only one goal during this whole block, so defensively very solid.
"The players have been stepping up big time, they've been owning this; we tried to relay it back to them all the time, so giving them the ownership.
"I'm just very happy with how the block has been, different challenges along the way, so all games have asked something different from us. We've responded to that really well, sticking to our identity but also playing the game that's ahead of us."
Arsenal qualifying for Champions League quarter-finals feel surreal, says Slegers
Renee Slegers says it feels "surreal" that Arsenal have secured their place in the Champions League quarter-finals with two games to spare.
The Gunners will finish at least second in Group C after Lina Hurtig's late strike secured a 1-0 win over Juventus on Thursday.
What looked to be a frustrating encounter was turned around by Slegers' substitutions, and after missing a glorious chance, Hurtig was eventually the difference at the Emirates.
Arsenal created 3.69 expected goals (xG) from their nine shots, getting three on target, compared to just 0.5 for Juventus, who tested Daphne van Domselaar the same amount of times.
Slegers was impressed by her side's resilience as they pushed to come away with all three points.
"It's surreal to be honest," Slegers said post-match. "I never felt we would get into this situation. We have done really well.
"I was part of Jonas [Eidevall's] staff and there was so much that was built during his time. I don't want to separate that. There is so much we are still building on. It's surreal in so many ways but we are very happy.
"I'm just happy for the team to win. Obviously, we have amazing depth in the squad, and we know anyone can do it for us - whether it's starting players or finishing players.
"It's the visualisation of how much everyone contributes in the team. I think that's what it means for us."
Slegers took over as interim manager following Jonas Eidevall's departure last month and has gone unbeaten in her first seven games, winning six and drawing one.
They have won each of their last five in all competitions, and have not conceded a goal in their previous four matches.
"It was just a very impressive block of the team," Slegers said. "We conceded only one goal during this whole block, so defensively very solid.
"The players have been stepping up big time, they've been owning this; we tried to relay it back to them all the time, so giving them the ownership.
"I'm just very happy with how the block has been, different challenges along the way, so all games have asked something different from us. We've responded to that really well, sticking to our identity but also playing the game that's ahead of us."
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