Veteran striker Zlatan Ibrahimovic will miss Milan's Serie A game with Empoli on Wednesday due to a knee injury.
Milan head coach Stefano Pioli confirmed the 40-year-old Swedish forward's absence along with Rafael Leao leaving him short of attacking options.
Ibrahimovic has netted seven league goals this term for Milan, who have only managed one point from their past two games, slipping four points behind leaders Inter in the league
"[Leao] won’t be there tomorrow, he’ll be back against Roma. Ibrahimovic won’t be there tomorrow because of an overload on his knee," Pioli told reporters.
Pioli was more positive about captain Alessio Romagnoli's prospects of playing, along with Theo Hernandez after illness amid an injury crisis at the club, without Simon Kjaer, Davide Calabria, Ante Rebic and Pietro Pellegri also out.
"Theo has become more complete, now he does the defensive phase better too," Pioli said.
"He gives us a lot on the attacking side. He’s better, I hope he’ll be in top condition tomorrow."
Pioli added that he paid little attention to the criticism levelled at his side lately, following Sunday's 1-0 home loss to Napoli who leapfrogged them into second spot.
"I read little, but some things are useful to improve," he said. "Against Napoli, Milan played a good match.
"We make mistakes that are not allowing us to get results, clearly we need to do something more. We need more quality."
Pioli added: "When results don’t come it’s right to be less calm, but also more determined.
"We have to think about tomorrow’s game, we want to get back on track after a home defeat. We wanted to score more points in the first half of the season than we did last year. It won’t be possible, but we want the three points tomorrow."
Milan have 39 points after 18 games, but have only collected eight points from their past seven league games.
Lazio 2-2 Milan: Leao salvages draw but Rossoneri still winless
Rafael Leao came off the bench to earn Milan a 2-2 draw with Lazio at the Stadio Olimpico on Saturday, but Paulo Fonseca's side are still without a Serie A win this season.
Milan were in front at the break through Strahinja Pavlovic's eighth-minute goal, the Serbian rising highest to power home a header from Christian Pulisic's corner.
However, Lazio hit back in the second half with Valentin Castellanos and Boulaye Dia scoring in quick succession.
Nuno Tavares' first-time ball into the centre was met by the unmarked Castellanos to level in the 62nd minute, then Dia tapped another Tavares cutback home to put the Biancocelesti ahead four minutes later.
Fonseca reacted by sending on four substitutes, and those changes had a swift impact as three of them combined for the leveller.
Theo Hernandez – who joined Leao in being dropped from the start – picked out Tammy Abraham, and his lay-off allowed Leao to escape Tavares to fire past Ivan Provedel.
The game was preceded by an emotional tribute to the man who led Lazio to their last league title, Sven-Goran Eriksson, who died at the age of 76 on Monday.
A Lazio shirt bearing the Swede's name was displayed on the home bench, while a banner held up by the home fans read: "You brought us to the top of the world... Have a good trip Mr. Sven."
Data Debrief: Milan's slow start continues
New Milan boss Fonseca is already under pressure after overseeing a return of two points from his first three league games at the helm.
It is the first time the Rossoneri have drawn two of their opening three matches in a Serie A season since 2011-12, when they also drew two and lost one,
They went on to finish second that season, just four points adrift of champions Juventus. If a title challenge is to take place this term, rapid improvements are needed.
Lopetegui rues missed opportunity as West Ham lose to Man City
West Ham manager Julen Lopetegui was not encouraged by the performance of his team despite losing 3-1 at home to Manchester City in their third league game.
“It is true that City is one of the best teams around the world for sure… but it is also true too that in the second half we have been very close to a draw,” he said speaking to BBC Match of the Day.
“I think we have played one very good second half. The start has been very good for us too.”
West Ham threatened for extended periods of the match and had chances to level the match at 2-1 down, with the best coming from Mohammed Kudus as he smashed a shot against the bar in the second half.
They also started the game brightly before going a goal down inside 10 minutes.
“In my mind we started very well, being aggressive,” said Lopetegui.
“We know in this plan normally they have initiative, it’s very difficult to not concede initiative then. That’s why you have to do a lot of very good things to overcome them.
“In the second half we had chances, I think we kept the ball much more, much more, and didn't concede a lot of chances."
But the hosts were ultimately undone by the brilliant finishing of Erling Haaland, who scored his second hat-trick in as many matches.
“He is one of the best players in the world, that's why he plays for Manchester City,” he said.
“You have to compete with these kind of players. City has the power and the quality to create chances.”
But ultimately, he was left frustrated at the sense of a missed opportunity and that his team were unable to earn themselves a draw that hadn’t seemed implausible during the match.
“Today I think the first goal was a pity for us but I’ve said it. I was happy with the performance think we were able to draw but again they damage us,” he said.
“Against this kind of team, if you make a mistake they don’t forgive. This is the difference they have… A little mistake they punish you, they punish us.
“We have to improve, to know to compete against this kind of team to be close to perfection.
“Don't make mistakes, be calm, defend well… we have quality players too.”
Bayer Leverkusen 2-3 Leipzig: Visitors fightback halts unbeaten streak for Alonso's side
Bayer Leverkusen suffered their first defeat in 36 Bundesliga matches, as Leipzig came from behind to stun Xabi Alonso's side 3-2 at BayArena.
Lois Openda struck twice for Marco Rose's, who recovered from 2-0 down to make it two wins from two and move to the summit of the table.
It looked like business as usual for the reigning Bundesliga champions when they scored twice in the last seven minutes of the first half through Jeremie Frimpong and Alejandro Grimaldo.
However, Leipzig replied deep into first-half stoppage time with Kevin Kampl reducing the deficit.
Openda then brought the visitors level in the 57th minute, before a stunning long-range strike completed the turnaround 10 minutes from time, condemning Leverkusen to their first league defeat in 15 months.
Data Debrief: Leverkusen's long streak comes to a shuddering halt
Leipzig became the first side to beat Leverkusen in a Bundesliga match since Bochum achieved the feat a staggering 462 days earlier.
The visitors have begun a Bundesliga season with two wins from two for only the second time, also doing so in 2019-20.
They are also now unbeaten in 13 league matches, their longest such streak since Rose took charge.
As for Leverkusen, their invincible streak is officially history, as is their 29-game unbeaten run on home soil.
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