Oscar Tabarez has been sacked as Uruguay coach, ending his 15-year reign at the helm of the national team.
The 74-year-old returned for his second spell in charge of Uruguay in 2006 – having also been in the role between 1988-1990 – after La Celeste's failure to reach the World Cup that year.
He led them to fourth place at the 2010 World Cup and presided over success in the 2011 Copa America.
However, after losing their past four games in World Cup 2022 qualifying, including a 3-0 defeat in Bolivia on Tuesday, Tabarez has been dismissed with Uruguay sitting in seventh place with four wins from their 14 games (D4 L6).
With four games remaining, they are just one point off Colombia in the fourth and final automatic qualification spot, but the Uruguayan Football Association (AUF) has taken the decision to act now.
A statement released by the AUF on Friday said: "[This is] a difficult decision due to present circumstances, in a commitment to the future and the achievement of the results we all want.
"We express our respect and acknowledgment to [Tabarez's] professionalism and dedication for such a long process."
Tabarez boasts the records for most games (74, including play-offs) and most wins (31) as head coach in the history of South American World Cup qualifying.
During his first stint in charge of the national team, Tabarez took Uruguay to the 1990 World Cup, being eliminated in the round of 16 by hosts Italy.
After his re-appointment in 2006, the former Boca Juniors and Milan boss took his nation to a further three World Cups (2010, 2014 and 2018).