Julian Nagelsmann confirmed Bayern Munich will be without Robert Lewandowski and Manuel Neuer for their DFB-Pokal clash with Bremer on Wednesday.
The head coach is set to rotate as Bayern launch their campaign against the fifth-tier side at Werder Bremen's Weserstadion.
Bayern are aiming to reclaim the trophy after suffering a surprise defeat against Holstein Kiel in the second round of last season's competition.
Nagelsmann has overseen an unbeaten start to the new season; Bayern taking four points from their opening two games while also retaining the Supercup after a 3-1 win over Borussia Dortmund.
And the head coach revealed he will rest some of his senior players ahead of their trip to Bremen.
"Manuel [Neuer] will be rested, as his foot has flared up again, as we expected," he said. "He won't travel to the game.
"Neither will Robert [Lewandowski], he will stay behind and do some intensive training here. The same goes for Leon [Goretzka].
"For them [Bremer], this is a once-in-a-lifetime game. In the end, the fact is that we need to and want to win, which means that we need to remain focused on the task at hand."
Nagelsmann will soon be able to call upon the services of Lucas Hernandez, who returned to team training on Tuesday.
The France international underwent surgery on a meniscus injury at the beginning of July and missed Bayern’s first three games of the season.
Nashville SC v San Jose Earthquakes: ‘A win would change everything’ - Godoy
Anibal Godoy insists that Nashville are already looking at their game against San Jose Earthquakes on Saturday as a must-win.
Nashville have won just once in the MLS this season and sit in 14th place in the Eastern Conference after a run of four without a win.
The Earthquakes, meanwhile, are bottom of the Western Conference having lost eight of their matches and recording just one win.
Godoy is aware of how their poor start to the season could affect their playoff hopes later down the line but is confident that Nashville can turn things around.
He said: “For us, it's an important week. It's a day we have to win, or we'll start to feel the pressure from other teams as they start to separate in the table.
“This league is long but if we want to get to the playoff you have to win games early on, especially at home.”
Liverpool agree compensation deal for Slot
Liverpool and Feyenoord have reached an agreement in principle over a compensation deal for Arne Slot to become the Reds’ manager next season, according to widespread Dutch media reports.
The Dutchman is reportedly poised to take over from Jurgen Klopp, who announced in January that he would be leaving the club at the end of the campaign.
Slot led Feyenoord to their second Eredivisie title last season after taking over the club in 2021.
It is believed that he topped the list of Liverpool’s favoured candidates due to his attacking playing style and ability to develop players.
Former Liverpool midfielder, Xabi Alonso, who led Bayer Leverkusen to their first Bundesliga title, and Sporting CP’s Ruben Amorim were also reported contenders to take over from Klopp.
Slot had already confirmed his interest in managing in the Premier League, both earlier this week and previously when he was linked to Tottenham in 2023.
QPR 4-0 Leeds United: Shock loss for Farke's men seals Leicester's promotion
QPR thrashed Leeds United 4-0 in the Championship on Friday, ensuring Leicester City booked their promotion straight back to the Premier League.
Ilias Chair was the star for the Hoops as he scored the opener and assisted two more goals to ensure QPR will stay in the Championship for another season.
Lucas Andersen, Lyndon Dykes and Sam Field also got their names on the scoresheet in an emphatic win for Marti Cifuentes' side.
Leeds' heaviest defeat of the season was a huge blow in the race for an automatic promotion spot, with Ipswich Town just one point behind them in third place with two games in hand going into their away clash against Hull City on Saturday.
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