A record-breaking defeat to Germany on matchday two leaves Portugal with work to do against France in a repeat of the previous European Championship final.
Portugal became the first defending champions to concede four goals at the Euros and now need at least a point to reach the last 16.
Top spot in Group F could still be theirs if they beat France, although Portugal's Euro 2016 final triumph was their only win against Les Bleus in 13 attempts.
Reflecting on the Germany match ahead of this tough test, coach Fernando Santos said: "We all felt disappointed on our way back.
"Everyone feels a sense of responsibility, and the following day the players reacted well.
"They are experienced players and appreciate that sometimes you don't win. There are times when even the top teams don't deal well with defeat."
France have never previously played Portugal before the semi-final stage of a major tournament, but their meetings tend to be low scoring. The previous four have provided only three goals.
Although Didier Deschamps' men are already through as at least one of the four best third-placed sides, the coach insists they do not lack motivation.
"To be honest, in the situation where we are now, if we had six points I would have the same thoughts because a negative result would have the same impact," he said.
"We have the insurance of being qualified already, that gives us some kind of tranquillity but it won't change our playing style.
"Of course we owe it to ourselves and the French people to deliver the best possible result."
PLAYERS TO WATCH
Portugal – Cristiano Ronaldo
When is Ronaldo not Portugal's player to watch? He has history in his sights, too, having tied Miroslav Klose as the leading scorer at Euros and World Cups combined (19 goals) and moved within three of Ali Daei's world-record 109-goal tally last time out. The Juventus superstar has never scored against France, though, his six goalless appearances his worst record in international football.
France – Antoine Griezmann
Griezmann was the subject of praise from Santos ahead of this match and is himself only three goals adrift of a benchmark for France. He has 11 goals at major international tournaments, with Michel Platini's 14 leading the way. He has Thierry Henry (12) and Just Fontaine (13) to leapfrog before reaching that record, though.
KEY OPTA FACTS
– This is the fifth match between Portugal and France at a major tournament, but it is the first time they have met in the group stages; all four previous encounters took place in the semis (Euro 1984, Euro 2000, World Cup 2006) or final (Euro 2016). France won the first three while Portugal came out victors in the Euro 2016 showpiece match.
– Following their 1-1 draw with Hungary on MD2, France have avoided defeat in more matches when trailing at half-time than any other team in European Championship history (six – W4 D2).
– France are unbeaten in each of their past 11 group stage games at major international tournaments (World Cup and Euros), winning seven and drawing four. However, each of their past three MD3 group games in these tournaments have ended level (D3).
– Last time out versus Germany (4-2), Portugal became the first reigning champions in European Championship history to concede four goals in a single match in the competition. Indeed, Portugal had never conceded four goals in a single European Championship match before facing Germany on MD2.
– Portugal have lost two of their past three matches at major tournaments (World Cup and Euros), one more than they had lost in the previous 17 such games combined (W8 D8 L1). They last lost consecutive such matches within a single tournament at Euro 2008.
Keane doubts Man Utd will crack top four under Amorim this season
Roy Keane does not believe Manchester United will get back into the Premier League's top four under Ruben Amorim this season due to a "real lack of quality".
The Red Devils legend was speaking after United started life under the Portuguese with a 1-1 draw at Ipswich Town, as Omari Hutchinson cancelled out Marcus Rashford's second-minute opener.
Keane acknowledged Amorim has to be given time to turn things around at Old Trafford, but does not see United cracking the top four this season.
"You have to give the man a chance," Keane told Sky Sports. "But the threat going forward, it's a huge problem for Man Utd. It's not good enough.
"Do I believe they have the quality to get them back to top four? Absolutely not. The evidence is not there. It's the same old stuff. Predictable and a real lack of quality."
United created 0.9 xG compared to Ipswich's 1.75 and had fewer shots on target (four) compared to Ipswich (six) at Portman Road.
They did have more touches in the opposition box (16 to 11) but had fewer final-third entries (48 to 61) and big chances created (two to three).
Ipswich were extremely resilient opponents after their early setback, and Tractor Boys boss Kieran McKenna praised his side, particularly Hutchinson after he grabbed his first Premier League goal.
"I thought he (Hutchinson) was a big threat first half, naturally more a winger, but most teams are going to press us high and in the spaces in the middle of the pitch having a dribbler in the middle of the pitch who's elusive and hard to pick up can be a big threat," he told Sky Sports.
"I think it's his first goal in the Premier League he'll be happy to have that of his back and he's improving."
"The first half, it's a blow to concede the early goal but I thought as the half went on we grew in the ascendancy, and the intensity of pressing and work on the ball.
"I thought we were the dominant team in the first half and deserved to be going in at least level. Second half in fairness, Man Utd had more control. It was difficult, we had to defend with real discipline on shape."
Leganes 0-3 Real Madrid: Mbappe and Bellingham score as Blancos close on Barcelona
Kylian Mbappe and Jude Bellingham were both on target as Real Madrid moved to within four points of LaLiga leaders Barcelona with a 3-0 win at Leganes.
Federico Valverde also scored for Carlo Ancelotti's side, who still have a game in hand on leaders Barca, who were pegged back in a 2-2 draw with Celta Vigo on Saturday.
Mbappe ended a goal drought of over 400 minutes after being teed up by Vinicius Junior shortly before half-time, moments after Leganes had surrendered possession near the edge of their own area.
Madrid dominated possession throughout the second half and doubled their advantage in the 66th minute, Valverde drilling a low effort home from a free-kick won by Bellingham.
Bellingham later got in on the act with a header on the rebound after substitute Brahim Diaz rattled the crossbar, as Madrid cruised to back-to-back league wins.
Data Debrief: Dirty work pays off for Madrid
Mbappe's opener, scored at a vital time shortly before the interval, set Madrid on their way to victory on Sunday.
Eduardo Camavinga and Bellingham both pressed high to help the visitors recover possession in the build-up, and Madrid have now scored five goals resulting from high turnovers in LaLiga this season – the most of any team across Europe's top five leagues.
This was the first time Ancelotti had faced Leganes in LaLiga, and he has now beaten all 28 different opponents he has come up against in the competition.
Napoli 1-0 Roma: Lukaku downs former club on Ranieri's return
Claudio Ranieri's Roma return was spoilt by Romelu Lukaku, whose goal against his old club sealed a 1-0 win for Napoli.
Ranieri was appointed Roma boss over the international break, with the 73-year-old coming out of retirement to take charge of the club for a third time.
Yet it was ex-Roma striker Lukaku who decided Sunday's contest at Stadio Diego Armando Maradona, with his 54th-minute effort sending Antonio Conte's team back to the top of Serie A.
Lukaku was well-placed to convert from Giovanni Di Lorenzo's cutback, bringing up his fifth Serie A goal of the campaign.
Roma, who had just two attempts and managed only 0.07 expected goals (xG) in the first half, woke up after Lukaku's goal, with Artem Dovbyk powering a header off the woodwork from a free-kick minutes later, but the visitors' comeback attempts proved fruitless.
Ranieri's next task is to rally his troops for a Europa League clash with Tottenham on Thursday.
Data Debrief: Ranieri's underwhelming return
There was no sign of an immediate upturn for 12th-place Roma, if they were hoping for a new-coach bounce.
Roma ended the first half with fewer than 70 successful passes (68). It is the first time they have had so few successful passes in the opening half of a league game since 2004-05.
With only three wins to their name in the league, they have won fewer than four matches in their opening 13 Serie A games for the first time since the 1978-79 campaign (also three).
And of course, it had to be Lukaku, who was leading their line last season, that delivered the hammer blow. The Belgium international has been involved in nine goals in Serie A this term (five goals, four assists). Only his former Everton club-mate Ademola Lookman, now a star at Atalanta, has contributed to more goals in the competition (seven goals, four assists).
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