The Serie A title has gone for both last season's champions Juventus and 2020-21 pace-setters Milan, but they still have plenty to play for on Sunday.
The two Italian giants are third and fourth heading into the weekend but neither are yet assured of Champions League qualification.
The losers when the sides meet in Turin – or both teams in the event of a draw – could soon be caught by those below them.
And Milan's preparations have been impacted by speculation around regular goalkeeper Gianluigi Donnarumma, as Stats Perform explains.
What's happened with Donnarumma?
The Italy international is out of contract at the end of the season and his failure so far to commit his future to the club has riled Milan supporters.
No Serie A player has made more appearances or starts (both 211) in the competition than Donnarumma since his 2015 debut – he ranks second behind Samir Handanovic (80) with 67 clean sheets – but fans reportedly confronted the keeper last week and demanded he either sign a new deal or sit out the Juve game.
It was an exchange that was said to have left Donnarumma in tears.
"It is important to firmly reiterate that nobody outside of Milan can decide who stays at the club and who renews," Milan technical director Paolo Maldini told ANSA in response.
"Choices regarding what happens on the pitch are down to the coach, while the club is in charge of contractual issues.
"From this moment, every single negotiation for new contract renewals is frozen until the end of the season so that the team can focus solely on the league.
"In the meantime, we will continue to protect our players, as we always have done."
A predictable complication is Juve's status as the most likely suitors for Donnarumma, who has lost more matches to the Bianconeri in Serie A (eight of 10) than any other side.
Why leave Milan?
Reported interest in Donnarumma from elsewhere is nothing new, but he has surely never been closer to quitting his only club.
The 22-year-old holds the power this time given his expiring contract, and patience could understandably be wearing thin at San Siro.
Donnarumma has been kept extremely busy by a misfiring Milan team in recent seasons. He ranks second for saves (609) and penalty saves (eight) – behind Andrea Consigli (642 and nine) in both categories – over the course of his Serie A career.
These heroics have not yet been enough to return the Rossoneri to the Champions League, where Donnarumma is remarkably still to make his bow, and a top-four finish in 2020-21 is now far from assured.
Milan were unbeaten in the league this season before hosting Juve in the reverse fixture in January but have since lost seven times.
A young team may be blowing their best shot at qualifying for Europe's top club competition, while Donnarumma's form has started to wobble, too.
The keeper has saved 72.6 per cent of shots since his Serie A debut, but that figure has dropped to 68.9 this term. He has also conceded 35 non-penalty goals from shots worth just 33.1 expected goals on target.
If Milan miss out on the Champions League again, Donnarumma could reasonably argue he is in need of a fresh challenge.
Would Juventus be interested?
Four keepers have made 100 or more saves in Serie A while keeping out a greater share of shots than Donnarumma during his Milan career. Two of them already play for Juve.
Along with Alisson (79.3 per cent), who left Roma for Liverpool, and Inter champion Samir Handanovic (73.1), Gianluigi Buffon (77.0) and Wojciech Szczesny (73.7) have bettered Donnarumma's output.
Juve may not even be getting an upgrade then if they tempt the Naples-born star away from Milan.
But Buffon is now 43 and Szczesny 31, meaning both are likely to wane as Donnarumma presumably improves.
Illan Meslier, in 2020-21 at Leeds United, is the only keeper born after Donnarumma to have made 30 starts in a single season in one of Europe's 'top five' leagues. Donnarumma has done so six times already.
And not only is the Italian young, he is, of course, cheap.
Juve love a bargain deal for a free transfer, willing to pay the various related sums to avoid transfer fees for Andrea Pirlo, Paul Pogba, Kingsley Coman, Sami Khedira, Aaron Ramsey and Adrien Rabiot, among others. And that was before the coronavirus pandemic and its financial crisis.
The Turin giants might be able to pick up their keeper of the future for nothing. Alternatively, he could on Sunday further dent their own Champions League aspirations.
Hurtig the hero after late goal sends Arsenal into Champions League quarters
Lina Hurtig's 89th minute winner ensured Arsenal progressed to the quarter-finals of the Women's Champions League after edging Juventus 1-0 on Thursday.
After being frustrated for large parts of the encounter, Hurtig bundled home from close range after Martina Lenzini's poor clearance to book the Gunners' place in the last eight.
Despite Arsenal dominating the early exchanges, it was Juventus who had the first sight of goal, though Eva Schatzer's effort was easy for Daphne van Domselaar to gather.
In a first half that saw just two shots on target, both coming from the visitors, Renee Slegers' substitutes proved to be the difference for Arsenal.
Slegers introduced Beth Mead, Stina Blackstenius and Hurtig late on, with the latter somehow putting Kim Little's cross over the bar from five yards out.
However, the Swede would atone for her earlier error, combining with fellow substitute Blackstenius to net against her former club and send them out of the competition with two group games remaining.
Meanwhile, in Group D, Barcelona edged closer to the quarter-finals of the competition with a convincing 4-1 victory over St. Polten at the Generali Arena.
The reigning champions are still three points behind Manchester City following their 2-1 win over Hammarby, and know a win against the Swedes next month will see them progress.
Kika Nazareth opened the scoring in the 20th minute after capitalising on a mistake by Kamila Dubcova, notching her second nine minutes later from close range.
Barca found themselves three goals up at the break when Vicky Lopez netted her first goal in the competition to put the result beyond doubt.
There was also a landmark moment for Alexia Putellas, who netted her 200th goal for the club with a well-taken effort into the far corner.
Valentina Madl took some of the shine off an otherwise impressive display from the visitors, who have now taken their tally to 20 goals from their four matches in the competition.
Guardiola agrees two-year contract extension with Man City
Pep Guardiola will be Manchester City manager for at least two more seasons after 2024-25, after he signed a two-year contract extension on Thursday.
The 53-year-old was coming to the end of his City deal, which was due to expire at the end of the current campaign, but he has opted to remain at the Etihad Stadium.
The deal itself will take Guardiola's tenure at the club to over a decade, making him City's longest-serving manager since Les McDowall in 1963.
There had been suggestions that he may leave at the end of the season following the announcement that director of football Txiki Begiristain was on his way out.
Guardiola was strongly linked with the England job after Gareth Southgate resigned in the wake of their Euro 2024 final defeat, but the Football Association appointed Thomas Tuchel last month.
“Manchester City means so much to me," Guardiola said. “This is my ninth season here; we have experienced so many amazing times together. I have a really special feeling for this football club.
“That is why I am so happy to be staying for another two more seasons.
“Thank you to everyone for continuing to trust and support me – The Owner, The Chairman Khaldoon, Ferran, Txiki, the players and, of course, the fans… everyone connected to Manchester City. It has always been an honour, a pleasure and a privilege to be here.
“I have said this many times before, but I have everything a manager could ever wish for, and I appreciate that so much.
“Hopefully, now we can add more trophies to the ones we have already won. That will be my focus.”
Having been appointed in 2016, Guardiola is by some distance Manchester City's most successful manager of all time, having won 18 major trophies during his time at the club.
That list includes their first-ever Champions League triumph in 2023 and six Premier League titles, including an unprecedented four on the spin.
He also boasts a 72.04% win percentage across all competitions, which is unsurprisingly the highest of any full-time City manager in history.
Shaw at the double as Man City progress in Champions League
Khadija Shaw scored twice as Manchester City beat Hammarby 2-1 to seal their place in the Women's Champions League quarter-finals.
Gareth Taylor's team entered Thursday's game with a perfect record in Group D, and their fourth win in as many European matches ensured they finished in the top two.
Shaw—the leading scorer in the Women's Super League this season with eight goals—put them ahead in the 31st minute, driving into the area after taking in Yui Hasegawa's pass before seeing her shot deflect into the top corner.
Shaw was booked for celebrating in front of the home fans despite appearing to have objects thrown at her from the stands, and Hammarby should have levelled when Julia Blakstad fired wide 10 minutes later.
The hosts did draw level three minutes into the second half as Ellen Wangerheim tapped home while City's Laura Blindkilde Brown was down appealing for a free-kick.
That parity was short-lived, though, as Shaw blasted into the top corner from 25 yards out, taking her overall tally for this season to 12 goals in all competitions.
In Group C, meanwhile, Bayern Munich lost their perfect record as they played out a 1-1 draw with Valerenga, boosting Arsenal's hopes of topping the pile.
Jovana Damnjanovic came off the bench to put Bayern ahead 15 minutes from time in Norway, but Elise Thorsnes headed home following an 88th-minute corner to snatch a point for the hosts.
Arsenal could now move within a point of Bayern when they face Juventus in Group C's other match later on Thursday.
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