For the first time since 2005, neither Lionel Messi nor Cristiano Ronaldo will be involved in the Champions League quarter-finals.
While Barcelona's exit to last season's runners-up Paris Saint-Germain was perhaps not too much of a surprise, few saw Juventus coming out on the wrong end of an upset against Porto in the last 16.
So, could we be witnessing a changing of the guard in the competition? Is it a case of out with the old, in with the new?
While Messi and Ronaldo have dominated in Europe through the years, a collection of some of the most promising talents in the world game have the chance to take centre stage now.
Erling Haaland (Borussia Dortmund)
Even by his own prolific standards, Haaland has been in sensational scoring form in the tournament so far.
His 10 goals in six games includes scoring a brace in each leg of the last-16 tie with Sevilla, helping Borussia Dortmund progress to the quarters.
The Norwegian striker managed the same number in a Champions League campaign last season that saw him represent both BVB and Salzburg. Forget just breaking the record as the fastest to 20 goals, he has shattered it. Harry Kane was previously the quickest to reach that number, doing so in 24 games – Haaland managed it in just 14.
His big chance conversion rate this season sits at a clinical 81.9 per cent, while he has also demonstrated his all-round impact by creating eight chances for his BVB colleagues.
Next in his sights is Manchester City, a team with family ties as his father, Alf-Inge, played for the English club in the early 2000s. Haaland has been linked with them too, along with plenty of other clubs, and Pep Guardiola has been suitably impressed by a player who does not turn 21 until July.
"The numbers speak for themselves, of course he is one of the best strikers in the world right now at his age," said Guardiola, who will be well aware that Haaland has the potential to ruin City's hopes of European glory.
Kylian Mbappe (Paris Saint-Germain)
Mbappe has six goals to his name in European outings in 2020-21, the same tally team-mate Neymar has managed for a PSG squad aiming to go one better than last year.
The France international hit a hat-trick in a 4-1 thrashing of Barcelona at Camp Nou, joining Faustino Asprilla and Andriy Shevchenko as the only players to record a Champions League treble against the Spanish heavyweights.
He was also on target when scoring a penalty in the drawn second leg, in the process becoming the youngest player to reach 25 goals in the competition, aged 22 years and 80 days. Messi was on the same pitch at the time his record was broken.
Mbappe has also demonstrated how he can provide for others, too. No forward from any of the teams still in contention can top his three assists, while only Karim Benzema (15) has bettered his total of 14 chances created.
PSG will be hoping the forward can continue his fine form when they take on Bayern Munich in a repeat of last year's final.
Phil Foden (Manchester City)
After three starts in the Champions League last season, Foden has risen from the periphery to become a prominent figure for Guardiola.
Only goalkeeper Ederson has played more minutes in the campaign so far for City than the versatile 20-year-old, who has contributed a goal and two assists to help ensure smooth progress to the last eight.
Foden has created the most chances for City during his appearances, his tally of 12 putting him just ahead of Kevin De Bruyne (11), while he has also been successful with 64.7 per cent of his attempted dribbles.
The playmaker is set to feature in the Champions League knockout stage for a fourth season before turning 21 – a feat only previously achieved by Cesc Fabregas (2004-05 to 2007-08) and Theo Walcott (2006-07 to 2009-10).
In the Premier League, Foden's 20 goal involvements (11 goals, nine assists) is comfortably the most by anyone aged 21 or under, showing just why he is no longer one to watch for the future but a player for the present, both for club and country.
Alphonso Davies (Bayern Munich)
It is not often a full-back catches the eye to the level that Davies managed during Bayern's triumphant Champions League run in 2019-20.
The most eye-catching moment of all surely came in his side's 8-2 rout of Barcelona in a quarter-final result that sent shock waves across European football, as he initially beat two opposing players before breezing beyond poor Nelson Semedo to set up a goal for Joshua Kimmich, one of his three assists in the competition.
Having arrived at the Bundesliga club as a left winger, the conversion to defence was made as quickly as he sprints up and down his flank (he clocked a top speed of 36.51 kilometres per hour in a Bundesliga game against Werder Bremen last year, the quickest speed recorded since such data began to be collected).
His participation in the group stage this season was limited by an ankle injury, with the 4-1 first-leg victory over Lazio in the last 16 just his second start.
However, the Canada international had no problems upon his return, having 101 touches (second only to team-mate David Alaba) while topping the list for Bayern in terms of tackles (four) and number of times possession was gained from the opposition (seven).
Guardiola insists three teams still in title hunt despite Liverpool slip-up
Pep Guardiola insists Liverpool remain in the Premier League title race, despite the Reds losing further ground on Arsenal and Manchester City in a dramatic few days at the summit.
Liverpool suffered a surprise 2-0 defeat to Merseyside rivals Everton on Wednesday, a result which meant they failed to close the gap to Arsenal after the Gunners thrashed Chelsea 5-0 on Tuesday.
While Jurgen Klopp's men couldn't respond to the Gunners pulling clear, City did on Thursday, with Phil Foden scoring twice in an emphatic 4-0 win over Brighton at the Amex Stadium.
One point behind Arsenal with a game in hand, City know five wins from their five remaining matches will seal an unprecedented fourth successive English top-flight title.
However, Guardiola expects further twists and turns in the coming weeks.
Asked if Liverpool were still in contention after City's win, Guardiola told Sky Sports: "Yeah. Many things can happen.
"What happened with Liverpool, losing to Crystal Palace and Everton, can happen to us. It can happen to Arsenal. No-one is safe. We have to rest. Now it is just about recovering for the next one.
"We have been here in the past but being here in the past doesn't mean it is going to happen. We have to do the things to make it happen."
City's comprehensive win – in which Kevin De Bruyne scored his first headed goal in the Premier League – saw them cut Arsenal's goal difference advantage to eight goals.
However, Guardiola believes it will be tough for City to close that gap, saying: "It is difficult to cut. The margin is so big. They score a lot of goals and don't concede.
"The main thing is to win the games. We have five games left and they are tough ones – it's a lot of games. We'll take it one game at a time."
Foden's first goal against Brighton – a deflected free-kick – saw him become just the third player to score 50 top-flight goals under Guardiola while aged 23 or younger, after Erling Haaland and Lionel Messi.
Foden is the favourite to be named Premier League Player of the Season, and while Guardiola believes he should be in contention, he says his player is more concerned with team honours.
"For sure, but he wants to win the Premier League," Guardiola said when asked if Foden deserved individual honours. "His influence in the final third was better than in the last two or three games. Today he was more calm, his decision-making was good and to score goals is always good."
Foden: De Bruyne the best in the Premier League
Phil Foden hailed Manchester City team-mate Kevin De Bruyne as the Premier League's best player after the pair both netted in the 4-0 win over Brighton and Hove Albion.
De Bruyne opened the scoring in Thursday's contest at Amex Stadium before Foden took over with a couple of goals of his own before half-time.
Julian Alvarez rounded off the scoring just after the hour in a one-sided contest as an Erling Haaland-less City moved to within a point of leaders Arsenal with a game in hand.
Belgium international De Bruyne now has four goals and six assists in just 13 league appearances for City this season.
Speaking to Sky Sports News after the win over Brighton, Foden said: "I think when he is at it, he is the best player in the Premier League."
Foden's first goal came via a deflected free-kick that he himself won, although replays showed he slipped rather than being fouled.
The England international doubled his personal tally with a composed finish after Brighton were caught in possession at the back.
Asked about playing more centrally, Foden said: "I have always said that I see myself there. This year I have moved inside and it has helped me massively.
"I enjoy it in the middle. It's where I want to be. At the moment, I am just enjoying my football and playing with freedom."
De Bruyne had earlier opened the scoring with a brilliant opener - his first headed goal for City in the Premier League - as City made it 30 games unbeaten in normal time across all competitions.
Alvarez then went on to round off the scoring in a game that not only saw the reigning champions close the gap on Arsenal, but also narrow the goal difference margin to eight.
"It was a good game," De Bruyne said. "I think we played really good in the first half and every game is a lot of pressure. All we can do is prepare as we did today and win the game that is in front of us.
"We just want to win game-by-game and push for the title. We don't get ahead of ourselves. Now the next game is coming quickly. Try to recover and we go again."
Kyle Walker assisted the De Bruyne and Alvarez goals - the first time the defender has set up two goals in a single Premier League game in what was his 390th appearance in the competition.
Reflecting on his rare headed goal, De Bruyne said: "It doesn't happen too much. Kyle gave a good cross and I think the only way I could reach it is by jumping to it. I will take it but it's not something I am good at."
City have rather ominously won four Premier League games in a row and travel to strugglers Nottingham Forest next up at the weekend, knowing victory in their remaining five games will secure an unprecedented fourth straight title.
"I trust my team. All respect to Liverpool and Arsenal, they are amazing," De Bruyne added. "Arsenal are doing what they need to do and we are also needing to do it. Work hard and be humble enough to keep pushing."
Brighton 0-4 Manchester City: Foden at the double as champions leapfrog Liverpool
Phil Foden scored twice as Manchester City leapfrogged Liverpool and kept the Premier League title race in their own hands by thrashing Brighton 4-0.
Foden moved onto 16 league goals for the season with a first-half brace at the Amex Stadium, seeing a free-kick deflect past a wrongfooted Jason Steele before stroking home after some reckless play from the Seagulls.
De Bruyne had earlier given City the lead with what was his 68th Premier League goal but the first with his head, as Pep Guardiola's men made light of Erling Haaland's injury-enforced absence.
Julian Alvarez added a fourth as City pulled two points clear of Liverpool and within one of Arsenal with a game in hand, knowing five further wins will guarantee they retain their crown.
Brighton, meanwhile, stay in the bottom half with 44 points, having been surpassed by Bournemouth on Wednesday.
Nathan Ake could not keep his shot down when presented with the first half-chance after a low-key start, but City went ahead with a brilliant goal after 17 minutes.
Foden slipped Kyle Walker in on the right flank, and De Bruyne watched the full-back's cross all the way before sending a wonderful diving header into the top-right corner.
There was more fortune about City's second, which arrived just nine minutes later as Foden's free-kick deflected in off Pascal Gross amid Brighton complaints about how Foden won the set-piece.
Brighton only had themselves to blame when Foden got his second after 34 minutes, though. Valentin Barco conceded possession cheaply on the edge of his area, and Foden swept the loose ball into the bottom-left corner.
Ederson denied Joao Pedro as Brighton improved in the second half, but City had further daylight just after the hour mark, Walker breaking in behind and beating Steele to a loose ball, with Alvarez on hand to turn home.
Brighton were enraged when Josko Gvardiol avoided conceding a penalty for a clumsy challenge on Pedro, who skewed wide late on as City – who went close to a fifth through Jeremy Doku late on and face struggling Nottingham Forest next – claimed a statement win.
Foden's star still rising
Foden has emerged as the favourite to be crowned Premier League Player of the Season, and he has gone up a gear in the run-in, also scoring a hat-trick on his last league appearance when City thrashed Aston Villa 4-1 earlier this month.
He was in imperious form again on Thursday, even if Brighton's fans were not happy with the way he went down for the free-kick that ultimately resulted in his first goal.
That strike was Foden's 50th in the Premier League, making him just the third player to score 50 top-flight goals under Guardiola while aged 23 or younger, after Lionel Messi and Erling Haaland.
It is no wonder Brighton's fans are sick of the sight of the England man; he has eight goals in his last eight Premier League appearances against the Seagulls, more than he has scored against any other club in the competition.
Seagulls' wings clipped
Hampered by injuries to the likes of Pervis Estupinan, Kaoru Mitoma and Evan Ferguson, Brighton have seen their European hopes falter in recent weeks and now appear to be limping to the finishing line.
Roberto De Zerbi's team are winless in their last five Premier League games (two draws, three defeats) and sit six points adrift of the top seven with matches against Bournemouth, Aston Villa, Newcastle United, Chelsea and Manchester United to come.
Brighton have even seen their supply of goals dry up, scoring just four times in eight league matches since thrashing Sheffield United 5-0 in February.
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