Teenagers Jamal Musiala and Florian Wirtz have been called up to Germany's senior squad for the first time, but there is still no place for Thomas Muller, Mats Hummels or Jerome Boateng.
Musiala, 18, pledged his allegiance to Germany last month having previously represented England at every level from Under-15 to Under-21.
The versatile attacker played in the Chelsea academy from 2011 until 2019 before opting to move back to Germany, where the Stuttgart-born youngster has since made quite the impression at Bayern Munich.
He has made 18 Bundesliga appearances this term – only four players who are younger than him (18 years, 21 days) have played in more matches across the top five European leagues this term.
One of those is Wirtz, who has shown immense promise at Bayer Leverkusen since making his debut shortly after his 17th birthday in May last year.
With four goals and as many assists in 21 Bundesliga games, Wirtz – a technically gifted attacking midfielder – is one of only two players under the age of 20 (along with Arnaud Kalimuendo) across the top European leagues to be involved in eight league goals.
Similarly, across those same leagues, Adil Aouchiche (46) is the only individual yet to turn 20 with more key passes than Wirtz's tally of 37.
Joachim Low, who earlier this month confirmed he will leave his post later this year, is urging both players to relax despite the added pressures that come with international recognition.
"We are excited to get to know Jamal Musiala and Florian Wirtz even better," he told the German Football Association (DFB). "They earned the nomination with their recent good performances.
"But especially with such young players, our responsibility is to be careful with them and lead them step by step to the highest level.
"Both have huge potential, and I am sure that we will have a lot of fun with them in the next few years, but at the moment it is important not to rush into anything, they should take it easy and develop carefree. I think the next few days will be a good experience for Jamal and Florian."
Amin Younes, who has been impressing with Eintracht Frankfurt this term, has earned his first call-up since October 2017, while Marc-Andre ter Stegen, Emre Can, Lukas Klostermann and Kai Havertz all return after missing the November internationals, which included a 6-0 humiliation by Spain.
However, there is still no recall for Bayern duo Muller and Boateng, nor Borussia Dortmund centre-back Hummels.
All three World Cup winners were cast aside by Low in March last year as he looked to refresh the squad in the wake of the 2018 World Cup failure.
Earlier this month, Low did not rule out potentially bringing them back into the fold given their solid form at club level, yet he has ignored them again on this occasion as Germany begin their World Cup qualification campaign with games against Iceland, Romania and North Macedonia.