Teenagers Jamal Musiala and Florian Wirtz have been called up to Germany's senior squad for the first time, but there is still no place for Thomas Muller, Mats Hummels or Jerome Boateng.
Musiala, 18, pledged his allegiance to Germany last month having previously represented England at every level from Under-15 to Under-21.
The versatile attacker played in the Chelsea academy from 2011 until 2019 before opting to move back to Germany, where the Stuttgart-born youngster has since made quite the impression at Bayern Munich.
He has made 18 Bundesliga appearances this term – only four players who are younger than him (18 years, 21 days) have played in more matches across the top five European leagues this term.
One of those is Wirtz, who has shown immense promise at Bayer Leverkusen since making his debut shortly after his 17th birthday in May last year.
With four goals and as many assists in 21 Bundesliga games, Wirtz – a technically gifted attacking midfielder – is one of only two players under the age of 20 (along with Arnaud Kalimuendo) across the top European leagues to be involved in eight league goals.
Similarly, across those same leagues, Adil Aouchiche (46) is the only individual yet to turn 20 with more key passes than Wirtz's tally of 37.
Joachim Low, who earlier this month confirmed he will leave his post later this year, is urging both players to relax despite the added pressures that come with international recognition.
"We are excited to get to know Jamal Musiala and Florian Wirtz even better," he told the German Football Association (DFB). "They earned the nomination with their recent good performances.
"But especially with such young players, our responsibility is to be careful with them and lead them step by step to the highest level.
"Both have huge potential, and I am sure that we will have a lot of fun with them in the next few years, but at the moment it is important not to rush into anything, they should take it easy and develop carefree. I think the next few days will be a good experience for Jamal and Florian."
Amin Younes, who has been impressing with Eintracht Frankfurt this term, has earned his first call-up since October 2017, while Marc-Andre ter Stegen, Emre Can, Lukas Klostermann and Kai Havertz all return after missing the November internationals, which included a 6-0 humiliation by Spain.
However, there is still no recall for Bayern duo Muller and Boateng, nor Borussia Dortmund centre-back Hummels.
All three World Cup winners were cast aside by Low in March last year as he looked to refresh the squad in the wake of the 2018 World Cup failure.
Earlier this month, Low did not rule out potentially bringing them back into the fold given their solid form at club level, yet he has ignored them again on this occasion as Germany begin their World Cup qualification campaign with games against Iceland, Romania and North Macedonia.
Kompany relishing 'special game' when Bayern travel to Frankfurt
Vincent Kompany is relishing a "special game" when Bayern Munich face Eintracht Frankfurt in a battle of the Bundesliga's top two teams on Sunday.
Bayern top the table with 13 points after their first five games, with Eintracht just a point behind after recovering from losing their opener with four straight wins.
However, Kompany's side travel to Deutsche Bank Park seeking a response after two winless games.
After their perfect start to the Bundesliga campaign was ended by a 1-1 draw with reigning champions Bayer Leverkusen, they went down 1-0 to Aston Villa in the Champions League on Wednesday.
Nevertheless, Kompany is only looking forward.
"It is a special game in Frankfurt against a very tough team," he told reporters during his pre-match press conference. "They have a lot of young players with a lot of talent, so the team can grow.
"For us, it is a normal game. We have to get our points and keep going in the Bundesliga. I am only focused on the next game.
"It is always important after every game, win or lose, to say the game is now behind us and now comes the next game. We have a lot to take into our next game and that should be the reason for our success."
Once again, Bayern will be without Jamal Musiala, who remains sidelined with a hip injury, and Kompany hopes to have the Germany attacking midfielder available as soon as possible.
"We know how good and how important Jamal is for the club and Germany," the Bayern head coach added. "He is a young player and our total priority is to get him back fit and stay fit."
Stokes out of first Pakistan Test through injury
England captain Ben Stokes is out of their first Test against Pakistan having failed to recover from a hamstring tear in time.
Stokes suffered the hamstring injury in August playing in The Hundred and has not played since, missing England's three-match series against Sri Lanka last month.
England said last week that the 33-year-old was "on track" to participate in the tour and trained away from the rest of the team in their first session.
Stokes confirmed he will miss the first Test, which begins on Monday in Multan, and Ollie Pope will continue to deputise as captain in his absence.
"I tried my hardest to get myself fit for this game but have taken the call to miss this one because I've not quite managed to get game-ready," Stokes told BBC Sport.
"There is a lot that has to go into my rehab programme. We got to a certain point, but looking at the picture of what we've got coming up and physically where I'm at, I'm not quite ready to play.
"It's always frustrating to miss out. I've got some good things to focus on, so even though I'm not playing, I've got a goal in mind."
The second Test starts on October 15, but the all-rounder admitted he was not sure whether that was a realistic target for his return.
"I've pushed myself incredibly hard and worked really hard with the medical team to get to where I'm at now. I think I'm further ahead than what we expected," he added.
"I'll be working just as hard over the next 10 days to try to get myself fit for the second Test."
In his absence, Durham seamer Brydon Carse will make his England Test debut.
He has previously played 19 ODIs and four T20s for England and will make his red-ball bow just over a month after completing a three-month ban for historical gambling offences.
England XI for first Test against Pakistan: Zak Crawley, Ben Duckett, Ollie Pope (captain), Joe Root, Harry Brook, Jamie Smith, Chris Woakes, Gus Atkinson, Bryson Carse, Jack Leach, Shoaib Bashir.
Sinner reaches 250 career wins after seeing off Daniel in Shanghai opener
Jannik Sinner notched up his 250th career win after defeating Taro Daniel in his Shanghai Masters opener.
The world number one wrapped up a commanding 6-1 6-4 victory over his Japanese opponent in just over an hour-and-a-quarter on Saturday.
Sinner, who is fresh from reaching the Beijing final last time out, is targeting his seventh silverware of the season, in which he has already triumphed at the Australian Open and US Open.
"I felt quite comfortable today," said the Italian, who set up a clash with 31st seed Tomas Etcheverry. "I also feel in good shape physically, which is very important for me.
"Of course, I will try to improve for tomorrow's performance, but today I was serving really, really well - especially in important moments - and was moving well."
Data Debrief: 250 up for Sinner
Sinner became the first player born in the 2000s to reach 250 career wins, while taking his tally for a remarkable campaign to 60.
The Italian, who won 64 matches last term, is the sixth player aged 23 or under to record 60 or more ATP wins in successive seasons, after Lleyton Hewitt, Andy Roddick, Roger Federer, Rafael Nadal and Novak Djokovic.
Sinner also maintained his perfect record in opening-round matches this year (14-0), and is now 51-0 against players ranked outside the ATP top 20.
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