Jonathan David's first-half penalty saw Lille stun Champions League holders Real Madrid on Wednesday, handing Los Blancos their first loss in any competition since January.
Fifteen-time European champions Madrid had not tasted defeat since going down to Atletico Madrid in the Copa del Rey 36 games ago, while they were also unbeaten in their last 14 Champions League outings.
But Los Blancos were flat from the off in France and had a couple of warnings before David converted from the spot in first-half stoppage time, after Eduardo Camavina handled from Edon Zhegrova's free-kick.
Andriy Lunin, standing in for the injured Thibaut Courtois, had earlier clawed David's attempt onto the post, while Endrick called Lucas Chevalier into action at the other end after becoming the youngest player to start for Madrid in the Champions League, at the age of 18 years and 78 days.
Zhegrova went close to a second Lille goal after the break, before Carlo Ancelotti introduced the fit-again Kylian Mbappe from the bench in a bid to find a leveller.
However, Los Blancos were unable to salvage a point with Dani Carvajal heading wide and Chevalier making an instinctive save to deny Antonio Rudiger at the death.
The result sees Lille move level with Madrid in the competition's new-look league phase, on three points apiece after two matches.
Data Debrief: Lille halt imperious Madrid
Madrid entered Wednesday's game unbeaten in their last 14 Champions League outings, but they were kept out by a resolute Lille rearguard – though they also had Chevalier to thank as Los Blancos failed to score from chances worth 2.09 expected goals (xG).
This is Madrid's first Champions League loss since they were crushed 4-0 by Manchester City in the 2022-23 semi-finals, and their first in the group stages since October 2022 versus RB Leipzig (2-3).
Ancelotti's men started with a home victory against Stuttgart on matchday one, but they are now winless in three straight European away games, drawing two and losing one.
That is their longest such run since November 2016, when they endured a run of four without victory on their travels (three draws, one defeat).
'It's a great night for everyone' - Genesio revels as Lille shock Madrid
Bruno Genesio revelled in "a great night for everyone", as "incredible" Lille stunned Champions League holders Real Madrid 1-0 at Stade Pierre-Mauroy.
Jonathan David's first-half penalty - after Eduardo Camavinga handled from Edon Zhegrova's free-kick - ended Madrid's 14-match unbeaten streak in this competition, while condemning them to a first reverse overall in 36 games.
Genesio also had Lucas Chevalier to thank after the Lille goalkeeper made a string of superb saves to keep Carlo Ancelotti's side at bay, including a wonderful instinctive stop to thwart Antonio Rudiger right at the death.
Indeed, Madrid simply had no answer to their stubborn hosts, despite the introduction of a fit-again Kylian Mbappe during the second half.
And Genesio saluted his players for their efforts in delivering a memorable result.
"What this team did is incredible," he said. "We try to put things in place, but you need the players to believe in the plan for this kind of upset to happen.
"You have to do everything perfectly, you need a keeper who makes the decisive saves, a striker who scores, and a bit of luck.
"We played a very good first half, we played together. It's a great night for everyone.
"We saw that Real like to cut inside, so we put intensity in that sector - even if we had to abandon possession sometimes.
"Then, it was all about pressing when it mattered. Everything worked perfectly, it was an ideal scenario - even if we suffered a lot in the last 25 to 30 minutes, but Lucas made the saves we needed."
Motta praises Juve spirit after thrilling fightback at Leipzig
Thiago Motta hailed Juventus' team spirit after they shrugged off two injuries and Michele Di Gregorio's red card to secure a thrilling 3-2 Champions League win over RB Leipzig.
Juventus, who are yet to concede a goal in Serie A this season, twice had to fight back from a goal down before securing the win with a late goal from Francisco Conceicao.
They endured a nightmare start as captain Bremer and winger Nicolas Gonzalez were both withdrawn after suffering injuries.
They then went down to 10 men when Di Gregorio was dismissed for handling outside his area, but Dusan Vlahovic's brace had them level before Conceicao showed great feet to tuck home an 82nd-minute winner.
"It was a good match, even in the first half where we made some mistakes in the details," said Motta.
"In the second half, we did better, even playing with 10 men. It was a great performance and a great win.
"Courage from the boys, they were determined to push forward and hurt the opponents.
"Even with a man down, we had that feeling, so why step back? We kept pushing, and we did it well right until the last minute."
Two-goal hero Vlahovic echoed those sentiments, saying: "I'm really happy, especially for the team. We are becoming a real unit.
"We fought together, kept pressing even when we were down to 10 men, and in the end, we deserved to win. It was a great match, and fortunately, we came out on top."
Dinamo Zagreb 2-2 Monaco: Zakaria snatches point at drenched Stadion Maksimir
Monaco came from two goals down to snatch a 2-2 draw at Dinamo Zagreb in the Champions League at a rain-sodden Stadion Maksimir, with Denis Zakaria equalising with an 89th-minute penalty.
Petar Sucic put Dinamo ahead in first-half stoppage time with a delightful chipped finish, later doubling their lead in 66th minute when Martin Baturina rifled home from outside the area.
Having been crushed 9-2 at Bayern Munich in their opening game, it looked like the Croatian side would bounce back in style, with Monaco struggling to get going on a sodden pitch.
However, Mohammed Salisu headed in from a corner with 16 minutes left to provoke a Monaco onslaught, and Maxime Bernauer fouled Folarin Balogun to concede an 89th-minute spot-kick.
Zakaria converted to put Monaco on four points after they beat Barcelona in their first match, with Dinamo defender Nenad Bjelica subsequently sent off when he picked up a second booking for dissent.
Data Debrief: Monaco show fighting spirit
Monaco looked set for a demoralising defeat in Croatia when they went 2-0 down, struggling to get their slick passing style to work on a pitch that was close to waterlogged.
However, they showed great resilience to fight back in the latter stages, avoiding defeat from two or more goals down in a Champions League match for the first time since May 2004, when they earned a 2-2 draw versus Chelsea en route to making the final.
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