Mikel Arteta confirmed Arsenal captain Martin Odegaard will be out "for a while" after suffering a significant ankle injury while playing for Norway.
The 25-year-old hobbled off during his country's Nations League 2-1 win over Austria in Oslo on September 9 and returned to London on crutches.
Odegaard missed Sunday's 1-0 derby victory against Tottenham and Arteta revealed the bad news on the midfielder ahead of Arsenal's opening Champions League game away to Atalanta.
"The scans showed that he's got some damage especially on one of the ligaments in the ankle," the Arsenal manager said on Wednesday.
"It's something quite significant so we're going to lose him for a while."
Arteta, whose side are second in the league and two points behind Manchester City, said he hoped it would not be months "but let's see".
Odegaard has become a key player for Arsenal, missing only a handful of games over the last three seasons, and a lengthy absence will come as a huge blow.
"He's our captain. He's been one of the biggest and best players in our team," continued Arteta.
"Our identity is very linked to how he plays and behaves. It's a big test for the team to see how able we are to show a different face."
Norway coach Stale Solbakken told VG newspaper he had been fully updated about the injury and was "preparing for a life without Martin".
"We have to take it week by week and day by day. Some types of damage go faster and some go slower," he said.
Napoli 5-0 Palermo: Five-star hosts cruise into Coppa Italia last 16
Cyril Ngonge scored twice in an electrifying performance, as Napoli breezed into the Coppa Italia last 16 with a crushing 5-0 win over Serie B Palermo on Thursday.
Ngonge struck first in the seventh minute with a left-footed drive that bounced in front of Salvatore Sirigu before squirming under his body into the net, leaving the goalkeeper shaking his head in disbelief.
Sirigu was at fault again five minutes later when Ngonge lashed another left-footer from a difficult angle, the ball flying across the face of the goal before nestling in the side netting to make it 2-0.
Palermo gave the hosts a scare as Matteo Brunori struck the post 29 minutes in, but Napoli were too big, too strong and too quick for their second-tier visitors, with Juan Jesus nodding home from a corner to make it 3-0 just before the break.
The visitors' hopes of a comeback were shattered when they were reduced to 10 men just before the hour mark. Aljosa Vasic was given a straight red card for dangerous play after catching Billy Gilmour in the face.
David Neres slotted home the fourth in the 70th minute, pressing to help win the ball back before coolly knocking into the net.
Scott McTominay then came off the bench to score with his first touch, rifling home a pass from fellow substitute Romelu Lukaku seven minutes later to complete the rout.
Data Debrief: A perfect performance
Conte's first game in charge was in the first round of this competition, and the Partenopei edged their way through with a penalty shootout win over Modena.
It was a totally different performance this time around though. They had 16 shots, seven of which were on target, accumulating just 1.55 expected goals.
Ngonge's part was perhaps the most impressive - he scored with both of his shots, with those chances equalling just 0.09 xG, though he just could not snatch a hat-trick in the second half to round off a brilliant game.
KC, JC, Excelsior all score heavily in Manning Cup wins
Kingston College, Jamaica College and Excelsior High all scored massive wins in ISSA/Digicel Manning Cup action on Wednesday.
KC hit seven past Meadowbrook High at Meadowbrook to remain atop Zone C with 13 points from five games.
Elsewhere in Zone C, Campion College dispatched Penwood 2-0 to draw level on 10 points with their opponents who are in second place on goal difference.
Jose Marti Technical edged Cumberland High 2-1 in the St. Catherine derby in the day’s other Zone C clash.
Zone F action saw leaders Jamaica College defeat Bridgeport High 9-0 with Giovanni Taylor bagging four goals as the standout performer. Excelsior High hammered Pembroke Hall 11-0 in the other game from the zone.
In Zone D, Vauxhall High grabbed a late equalizer to secure a 1-1 draw against Camperdown High to remain unbeaten this season.
STATHS displayed a vintage performance as they held firm to secure their third win of the season with a 1-0 victory versus Haile Selassie and remain top of the zone with 10 points from their four outings.
Celta Vigo 0-1 Atletico Madrid: Super-sub Alvarez snatches last-gasp win
A late Julian Alvarez goal earned Atletico Madrid a dramatic 1-0 win at Celta Vigo on Thursday to lift them to third in LaLiga.
Atletico looked to be heading to a second straight draw, but the substitute was alert in the final minute of the 90 to ensure they returned to Madrid with all three points.
Goalkeeper Jan Oblak was key as Celta suffered their first home defeat of the season, producing an excellent save to deny Iago Aspas at his near post just before the break.
He kept his side in it throughout a poor showing, also keeping out Borja Iglesias twice after the break as Celta struggled to find their clinical edge.
But big-money signing Alvarez struck in the dying minutes, stretching out a leg to meet Antonie Griezmann's pinpoint cross to poke his second goal of the season past Vicente Guaita.
Data Debrief: Atleti ride their luck
It was not a vintage performance for Atletico by any stretch of the imagination, which was only confirmed as Oblak was awarded player of the match at the end of the contest.
The visitors only had two shots on target (from eight attempts), with both of those coming in the final 11 minutes as they accumulated just 0.63 expected goals.
Celta's profligacy came back to haunt them though as they had 10 shots, four of which hit the target, with three of those classed as big chances. They created an xG of 1.37, but just could not find a way past Oblak.
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