Brazil were dumped out of the Copa America by 10-man Uruguay, who survived Nahitan Nandez's red card to win on penalties after a bad-tempered, goalless quarter-final.
Marcelo Bielsa's team played the final 16 minutes a man down after Nandez was dismissed for a reckless lunge on Rodrygo, but with star winger Vinicius Junior suspended, Brazil were unable to find a winner and were made to pay in the shoot-out.
Sergio Rochet saved from Eder Militao before Douglas Luiz struck the post, and though Jose Gimenez squandered Uruguay's first chance to win it, Manuel Ugarte made no mistake with their next attempt.
They will now face Colombia in the last four after James Rodriguez inspired Los Cafeteros to a 5-0 rout of Panama, while Brazil's wait for a 10th Copa title goes on.
Brazil struggled to match Uruguay's intensity early on and survived a couple of close calls. Darwin Nunez saw a header hit Militao and drop just wide of the left-hand post before Mathias Olivera powered over the crossbar from the resulting corner.
The Selecao's first opening came just before the half-hour mark as Endrick intercepted a loose back pass from Matias Vina before finding Raphinha, who was just unable to get his shot off.
Uruguay lost Ronald Araujo to a hamstring injury 33 minutes in, and though the game became littered with fouls, both sides carved out chances before the interval.
Nunez should have done better when he headed Nandez's glorious right-wing cross over, then Raphinha twice shot straight at Rochet after scampering in behind.
Federico Valverde fired over after the break as the blood-and-thunder nature of the game continued. Referee Dario Herrera repeatedly dipped into his pocket as the challenges became ever more rugged, and with 74 minutes played, he brandished a red card.
Originally booked for catching Rodrygo in full flight with his studs high on his opponent's ankle, Nandez was given his marching orders following a VAR review.
Penalties were Uruguay's goal from then on as they sacrificed Nunez for an extra defensive body and sat deep, and they got over the line as Endrick sent a tame effort straight at Rochet, making it three of four Copa quarter-finals to go to a shoot-out this year.
While Uruguay's first three kicks were perfect, Rochet got down to palm Militao's effort away and Luiz struck the left post, putting La Celeste on the brink.
Captain Gimenez was denied by a fine stop by Alisson, but Ugarte kept his nerve to blast his kick home and win the tie.
Uruguay battle through
Alongside the vibrant atmospheres and silky skills on display at the Copa America, the tournament is often characterised by a little rough and tumble.
That was certainly the case on Saturday, with Uruguay's 26 fouls committed the highest figure recorded by any team at this year's tournament, the previous high being 20 (by three teams).
Endrick and Rodrygo were bullied out of the contest, even failing to make their mark after Nandez's terrible challenge on the latter gave the Selecao a one-man advantage.
While Uruguay have won plaudits for their free-flowing approach under Bielsa at this tournament, it was their old grit that got them over the line on Saturday, with South America's great overachievers punching above their weight once again.
Penalty pain for toothless Brazil
Penalties were Brazil's nemesis at the 2022 World Cup in Qatar, as they were stunned by Croatia at the quarter-final stage, and it was a similar story here.
It was their failings in regulation time, however, that cost them.
After Nandez's 74th-minute dismissal, Brazil only managed two shots of any description. The first came from the free-kick that resulted from Nandez's foul, and the second was a tame 20-yard attempt from Endrick.
Endrick, remarkably, played the full 90 minutes and only completed one pass, from kick-off.
In total, the two teams managed just 21 touches in the opposing penalty areas, the joint-fewest in any game at this tournament, alongside Costa Rica versus Paraguay.
Arsenal left wanting at Hacken as Man City seize control in Champions League qualifier
Arsenal are facing an uphill battle after a surprise defeat in their Women's Champions League qualifier, though there was no such shock for Manchester City.
Jonas Eidevall's side were defeated 1-0 in the first leg away to Hacken on Wednesday, leaving a comeback needed in the reverse fixture next Thursday.
An error from visiting defender Katie McCabe, who missed a clearance from a diagonal pass, led to Tabitha Tindell's 77th-minute winner at Bravida Arena.
Arsenal face Man City in the Women's Super League between the two Hacken clashes, and Gareth Taylor's side will head into that domestic fixture with growing confidence from a fine European showing.
City ran out comfortable 5-0 winners away to Paris FC, with Vivianne Miedema scoring the opener on her competitive debut for the club.
Jess Park doubled the lead shortly after, and added a second to her own account later on, along with goals for Mary Fowler and Chloe Kelly in a one-sided outing in France.
Elsewhere in the qualifiers, Juventus secured a 3-1 first-leg lead in a battle of two heavyweights with Paris Saint-Germain.
New signing Amalie Vangsgaard opened the scoring against her former club before Thiniba Samoura levelled with a sumptuous equaliser soon after.
Sofia Cantore set up Juve's first and found the net for the home side's second to restore their lead, before Hanna Bennison wrapped up a fine team move to seal a commanding advantage.
There was no such fortune for Juve's fellow Italian side Fiorentina, however, as Wolfsburg produced a 7-0 hammering in the first leg at Viola Park.
Wolfsburg captain Alexandra Popp dominated with a hat-trick, along with a brace from defender Marina Hegering and goals for Jule Brand and Vivien Endemann.
Sparta Prague 3-0 Salzburg: Hosts end 21-year wait for Champions League win in style
Sparta Prague enjoyed a fine return to the Champions League on Wednesday, recording a 3-0 win over Salzburg in their first game in Europe's top club competition in 19 years.
Sparta grabbed an early lead that set the tone for the league-phase opener at the Epet Arena as home fans celebrated their team's first win in the tournament since 2003.
The hosts opened the scoring just two minutes in when Kaan Kairinen pounced on a loose ball after a great save by Salzburg goalkeeper Janis Blaswich, effortlessly slotting home the rebound.
Victor Olantuji then doubled their lead in the 42nd minute, firing in from a tight angle after taking in a long ball over the top from captain Filip Panak.
Olantuji then turned provider as the hosts killed the game off just before the hour mark, assisting Qazim Laci for a coolly struck finish after a cheap giveaway from Salzburg.
Data Debrief: Long wait ends for Sparta
Sparta's victory, their first in the Champions League since beating Lazio 1-0 in December 2003, saw them halt a 14-game winless run in the competition (four draws, 10 losses).
It is also the first time they have ever started a Champions League campaign with a win, on their eighth appearance in the competition proper.
Bologna 0-0 Shakhtar Donetsk: Skorupski heroics preserve point for Rossoblu
Bologna were held to a 0-0 draw by visitors Shakhtar Donetsk, who saw an early penalty saved, in a lacklustre Champions League opener on Wednesday.
The first half lacked excitement, but Bologna's fans relished the milestone occasion as they returned to Europe's elite club competition for the first time in almost 60 years.
The game was four minutes old, though, when the visitors had a chance to take the lead, Stefan Posch fouling Eguinaldo to concede an early penalty.
However, Bologna goalkeeper Lukasz Skorupski denied Heorhiy Sudakov from 12 yards, and that was the most dramatic moment of an otherwise tepid affair.
Despite an energetic start to the second half and a couple of impressive saves from Shakhtar keeper Dmytro Riznyk, neither team could make a breakthrough, taking a point apiece from their first outing in the competition's new-look league phase.
Data Debrief: Skorupski the hero
In a game low on attacking quality, Bologna goalkeeper Skorupski made headlines with his early penalty save, becoming the sixth Polish shot-stopper to keep out a penalty in the Champions League.
It also means that three of the last four penalties taken in the first four minutes of a Champions League game have not found the net.
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