Ademola Lookman produced a performance for the ages as his hat-trick ended Bayer Leverkusen's 51-game unbeaten streak and saw Atalanta claim the Europa League with a 3-0 win in Dublin.
Xabi Alonso's Bundesliga title champions were eyeing an unlikely treble this season, but those plans came to a crashing halt as Atalanta secured their first-ever European silverware.
Lookman did the early damage with his first-half brace, the second of which was an eye-catching solo strike, as Gian Piero Gasperini's Serie A side seized unexpected control on Wednesday.
Comeback masters Leverkusen may have fancied a late fightback but Lookman's thumping 75th-minute finish completed his hat-trick and ensured Alonso's team suffered defeat for the first time this season, in what was their penultimate match of an exceptional campaign.
Leverkusen were punished for a slow start as Atalanta, making their maiden appearance in a European final, capitalised with just 12 minutes gone at the Aviva Stadium.
Exequiel Palacios was caught unaware at the back post as Davide Zappacosta slammed a low right-sided cross for Lookman to fire into the top-left corner from close range.
Lookman doubled his tally 14 minutes later, coolly flicking through the legs of Granit Xhaka before curling a right-footed finish into the bottom-right corner from the cusp of Leverkusen's area.
Alex Grimaldo should have responded shortly after but aimed a timid lob straight at the onrushing Juan Musso, who gratefully grasped the chipped effort when way out of his goal.
Charles De Ketelaere fizzed into the hands of Matej Kovar, while Granit Xhaka whipped wide before Alonso introduced striker Victor Boniface at the break.
That alteration failed to change the tide as Jeremie Frimpong blazed over the only chance before the hour-mark – and there would be no way back after Lookman scored his third with 15 minutes remaining.
Gianluca Scamacca played a simple offload out to his left, with Lookman breezing past Edmond Tapsoba before cannoning a wonderful left-footed strike beyond Kovar to seal a famous night for the team from Bergamo.
Atalanta savour legend Lookman
Lookman has etched his name into Atalanta history after helping Gasperini's side become the first Italian side to win the Europa League.
The Nigeria international is the sixth player to score a hat-trick in the final of a major UEFA competition, and the first since Jupp Heynckes' for Borussia Monchengladbach in the 1975 UEFA Cup.
Lookman's match-winning heroics will live long in the memory of Atalanta supporters, who will cherish just their second major trophy in club history – 61 years after winning the Coppa Italia.
Neverlusen comes to an end
Prior to this stunning defeat, Leverkusen were undefeated in all 12 Europa League games this season (W9 D3) and aiming to become the fourth side to win the trophy unbeaten, along with Chelsea in 2018-19, Villarreal in 2020-21 and Eintracht Frankfurt in 2021-22.
Adding in their nine-month unbeaten run, which spanned back to a first-round DFB-Pokal thrashing of Teutonia Ottensen in mid-August, Alonso's side appeared the favourites for this clash.
Yet form went out the window as Atalanta – who also eliminated Liverpool in the quarter-finals – inflicted Leverkusen's first defeat across all competitions in 361 days, and Alonso must now rally his troops for the DFB-Pokal final on Saturday.