Mauricio Pochettino called for measures that prioritise rest time for players after a run of three games in seven days for Chelsea.
The 3-2 victory over Luton at Kenilworth Road on Saturday, which ended a streak of four consecutive away losses in the Premier League, was the eighth match his team has played in December.
The Professional Footballers’ Association (PFA), which represents the interests of players, is understood to be exploring the possibility of taking legal action over the number of games in which teams are expected to take part.
It comes ahead of the imminent launch of a new format for the Champions League which could see as many as four extra games added to clubs’ schedules, while the 2026 World Cup will feature 48 countries for the first time.
Chelsea are also due to take part in FIFA’s expanded Club World Cup set to take place in the United States in the summer of 2025.
Pochettino, who is one of a number of top-flight managers to have had to contend with an injury crisis during his first six months in charge at Stamford Bridge, said more must be done to protect players amid growing commitments.
“It’s a business that provides many people in many different areas with a comfortable life,” he said. “(But) of course it’s a business where the players are the principal actors. We need to care about them.
“It’s true that it’s the only sport in the world where the players compete for 10, 11 months. Sometimes we need to manage better the way to rest the players, to give the possibility for recovery.
“When we compare with other sports, only footballers are competing for nearly 11 months.
“When you increase the level of competition, football is fast, the players run more, we push them every day to improve and improve their physical condition. But they need rest.”
Pochettino has had to do without a number of key players for long periods this season, most notably his captain Reece James who recently underwent hamstring surgery, as well as Ben Chilwell and new signings Christopher Nkunku and Romeo Lavia.
Defenders Wesley Fofana and Trevoh Chalobah have not played this season, while Lesley Ugochukwu has been unavailable since the second weekend of the campaign.
“It’s a good point to all realise that (there are) 11 players, in the squad 22,” said Pochettino. “When the manager makes changes it’s so not to play the same starting XI every single game.
“It’s to restrict, so players don’t start every two to three days in a busy period. It’s many ideas we need to share all together to find the best solution.
“There have been too many injured the last few years. We need to be cautious about the situation, we need to look after better our players.”
Simeone insists Atletico 'cannot stop pushing' after narrow Mallorca win
Diego Simeone insists Atletico Madrid "cannot stop pushing" in their pursuit of Champions League qualification after a narrow 1-0 victory over Mallorca.
Los Rojiblancos tightened their grip on fourth place in LaLiga, with Rodrigo Riquelme's fine individual effort in the fifth minute enough to secure back-to-back wins.
With four games remaining, Simeone's side moved onto 67 points, six clear of fifth-placed Athletic Bilbao, who they beat 3-1 last weekend.
The Atleti boss was thrilled by his players' performance levels, but has urged them not to rest on their laurels.
"The team interpreted the plan very well," he said. "The commitment was incredible from [Angel] Correa to [Jan] Oblak to play an intelligent game from a defensive point of view.
"After the goal, we controlled the game. We defended as a team and did a great job. We need to continue improving, and we can't stop pushing until the season is over."
Echoing his manager's thoughts, defender Axel Witsel told Movistar Plus+: "It was very important to win. We wanted to win and stay six points ahead. We have to keep it up.
"After Riquelme scored a fantastic goal, we managed to stay well-organised to secure the result."
'It hurts to lose' - Inzaghi apologises after Sassuolo defeat
Simone Inzaghi admits "it hurts to lose" following Inter's surprise 1-0 defeat by relegation-threatened Sassuolo.
The newly crowned Scudetto winners suffered only their second loss of the season in Serie A, as Armand Lauriente's first-half goal was enough to give the 19th-place hosts victory at Mapei Stadium.
Sassuolo, who boosted their survival hopes, subsequently completed the league double over the Nerazzurri, having also prevailed 2-1 at San Siro in September.
Meanwhile, Inter were beaten by a team in the bottom two for the first time since November 2014, with Inzaghi urging his players not to be distracted by their title triumph.
"We started sluggish and didn’t have the right approach to the game," he told Sky Sports Italia. "I'm sorry for the defeat, but credit must be given to Sassuolo for a performance of great effort and sacrifice.
"It's right to enjoy [our Scudetto victory], but there are still three games to go and we have to focus. It hurts to lose, and it should hurt."
After guiding Inter to their 20th Serie A crown, Inzaghi is hopeful he can keep the majority of his squad intact ahead of next season.
However, the Nerazzurri boss did emphasise the club's need to strengthen before launching their Scudetto defence.
"I already told the club that I want to go into next season with all the players I had this term, not losing a single one," he said. "Considering all the games we need to play and the length of the season, we do need a bigger squad."
Inter Miami 6-2 New York Red Bulls: Messi makes more MLS history as Suarez scores hat-trick
Lionel Messi had a hand in all six goals while Luis Suarez scored a hat-trick as Inter Miami overcame the New York Red Bulls 6-2 at Chase Stadium.
The Eastern Conference leaders were on a three-match winning streak in MLS, but fell behind to Dante Vanzeir's opener in the 30th minute.
However, the hosts turned the match on its head after the break, with Messi assisting a brace for half-time substitute Matias Rojas either side of getting on the scoresheet himself.
Suarez then took centre stage with a hat-trick inside 13 minutes - all assisted by his former Barcelona team-mate - while Emil Forsberg's stoppage-time penalty was a mere consolation for the visitors, who are now without a win in four.
Data debrief
Messi broke two more MLS records following yet another inspirational display for the Herons.
The eight-time Ballon d'Or winner's six goal contributions and five assists were both the most recorded by a player in a single game.
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