Bayern Munich will check on Leon Goretzka and Joshua Kimmich ahead of their final Bundesliga match before the winter break against Wolfsburg.
The midfield pair missed the weekend win over Stuttgart with illness and they are still being monitored.
Goalkeeper Sven Ulreich is not fit to return to the squad so Daniel Peretz will continue to deputise.
“We hope there are no more ill players,” Thomas Tuchel said on the club’s official website. “It’s an hourly update with Leon Goretzka and Joshua Kimmich. It’ll be tight for both. We think the rest are fit.
“It looks like Daniel Peretz will be in the squad again with Ulle not yet back.”
Bayern are guaranteed to go into the winter break in second position in the Bundesliga table following an excellent first half of the campaign by Bayer Leverkusen.
They will have work to do if they are to claim a 12th title in a row, but Tuchel wants his side to finish on a high.
“Our work is always about looking ahead,” he added. “A lot has happened this year. We’re making good progress and are trying to meet our tasks.
“We want to continue developing our team. It’s all good and we’re looking forward to a break. But we want to take the next step in Wednesday’s game.
“We want to be better in possession. Wolfsburg have different tactics from Stuttgart. We’re again expecting a back five.
“We want more of the ball and will now take on a new task. It’s down to us. How good are the movements and distances? Let’s see what challenges the game brings. We hope we can have the right answers.”
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Tuchel is keen to temper expectations of teenager Aleksandar Pavlovic following his breakthrough in the team in recent weeks.
The former Chelsea boss said: “We knew before that we have Aleks and what he can do. He was always good in training. It helps nobody if Aleks is our solution in that position now at 19.
“We’ll do everything that makes sense for the club and youth development. We’re the biggest fans of our own youth players from the Campus. Aleks has earned it with the way he is and how he trains. It’s good if we don’t overpraise someone.
“It’s good what he’s doing. He always has a smile on his face and is very grounded. Quality always comes through.”
'I love where I am,' says Simeone after 700th game in charge of Atletico
Diego Simeone said he is "calm and at peace" at Atletico Madrid after his side edged Deportivo Alaves 2-1 in LaLiga in his 700th game in charge of the club.
Atletico went behind through a Jon Guridi penalty in the seventh minute, but Antoine Griezmann drew them level from the spot in the 76th minute.
The winner came via Alexander Sorloth in the 86th minute as Atletico moved four points behind leaders Barcelona.
Simeone, who has been in charge of Atletico since 2011, is the first coach to manage 700 matches with the same LaLiga club.
"I live in the present, we are having a good time, the boys are working very responsibly," Simeone told DAZN.
"I am calm and at peace. I love where I am and that's it."
He managed Atletico to LaLiga title triumphs in 2014 and 2021 and also helped Los Rojiblancos win two Europa League titles in 2012 and 2018.
The game against Alaves was Simeone's 492nd LaLiga match in charge, and the Argentine has also managed the third-most games with a single club in the Champions League (109), after Alex Ferguson with Manchester United and Arsene Wenger at Arsenal.
AC Milan 0-0 Juventus: Bianconeri maintain unbeaten start after Rossoneri stalemate
AC Milan and Juventus shared the spoils following a dour goalless draw at San Siro.
The Bianconeri maintained their unbeaten start to the Serie A season, but missed the chance to go second behind leaders Inter after a game lacking in quality and chances.
With the likes of Dusan Vlahovic and Arkadiusz Milik out injured, Juventus began the game without a recognised striker, as Teun Koopmeiners and Weston McKennie led the line.
Koopmeiners hit the side-netting from a tight angle after 10 minutes, while Kenan Yildiz grazed the post following a fine individual run midway through the half.
Alvaro Morata had Milan's best chance at the other end, but the former Juventus striker could only head wide from Rafael Leao's free-kick.
Opportunities did not fall as freely in the second half either, and both teams left the field to a chorus of boos on the referee's final whistle.
Data Debrief: Stubborn Juve take clean sheet tally into double figures
Juve are the first team to register 10 clean sheets in their opening 13 matches of a Serie A season since Roma (also 10) in 2013-14.
The Bianconeri have also kept five clean sheets in their first six away league games in a campaign for only the fourth time, also achieving the feat in 1967-68, 2004-05, 2023-24.
Meanwhile, Thiago Motta is only the fifth Juventus manager to go unbeaten in his first 13 league matches in charge (won six, drawn seven), after Jesse Carver, Cestmir Vycpalek, Antonio Conte and Maurizio Sarri.
Manchester City 0-4 Tottenham: Guardiola's champions humiliated in fifth straight loss
Manchester City's losing streak stretched to five games across all competitions as Tottenham stunned the Premier League champions with a 4-0 victory at the Etihad Stadium.
On his 28th birthday, James Maddison scored twice in the first 20 minutes as Ange Postecoglou's visitors caught out their hosts on the counterattack.
Maddison was found unmarked at the far post by Dejan Kulusevski for his opener, then exchanged passes with Son Heung-min and dinked a fine finish over Ederson for his second.
City continued to dominate possession but struggled to find a killer pass, and their hopes of a second-half fightback were dashed when Pedro Porro – who spent three years as a City player between 2019 and 2022 – capped another lightning break early in the second half.
Erling Haaland clipped the crossbar but that was as close as City came to making it competitive, with Brennan Johnson completing the rout following fine work from Timo Werner, as the worst run of Pep Guardiola's managerial career continued.
Second-placed City could now find themselves eight points adrift of the summit after Liverpool’s trip to Southampton on Sunday.
Tottenham, meanwhile, climbed to sixth in the table, four points behind City.
Data Debrief: Uncharted territory for Pep
City have now lost five straight matches in all competitions, including two versus Tottenham after they were also beaten in the EFL Cup last month.
They are the first reigning top-flight English champions to lose five games in a row since Chelsea did so in March 1956.
This is the worst losing streak of Guardiola's glittering managerial career, with City last losing six in a row under Stuart Pearce in 2006.
Should their dismal run continue at Liverpool in eight days' time, their title defence may be in tatters before the festive season has even begun.
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