Celtic suffered more Champions League pain at Parkhead as Lazio scored a stoppage-time winner soon after the home side were denied a goal following a lengthy VAR check.
With the score at 1-1, substitute Luis Palma fired home in the 81st minute after Daizen Maeda had attempted an overhead kick from Alistair Johnston’s cross, and the VAR officials decided he was offside.
There was a bigger blow to come when former Barcelona and Chelsea forward Pedro headed home from fellow substitute Matteo Guendouzi’s cross five minutes into stoppage-time to secure the Italian club a 2-1 win in Group E.
Celtic had taken an early lead through Kyogo Furuhashi but Matias Vecino levelled following a 29th-minute corner.
Brendan Rodgers’ side looked the likelier team to find a winner but their 10-year wait for a home victory in the Champions League group stage continues and the ninth defeat in that 11-game run would be the most difficult one to take after a largely encouraging performance.
The tie was a resumption of hostilities from four seasons ago when Celtic triumphed home and away against Lazio in the Europa League, their victory in Rome sealed by Olivier Ntcham, who appeared on a massive pre-match banner among the home fans in the standing section.
Celtic settled quickly and Furuhashi netted his first goal in eight Champions League appearances 12 minutes in.
The Japanese striker’s finish went through the dive of goalkeeper Ivan Provedel after he was played through by a first-time pass from Matt O’Riley after positive play from Maeda.
The atmosphere went up a notch but Celtic did not build on their advantage. Despite having plenty of possession in the aftermath of the goal, most of it was inside their own half and the occasional slack pass put them in danger.
They had a chance on the break when Yang Hyun-jun played Maeda in behind but the Japanese attacker mis-kicked his ambitious effort.
Lazio’s territorial advantage paid off when they won three headers in a row from Luis Alberto’s corner. Joe Hart appeared to have saved the third one from Vecino but the Lithuanian referee ruled the ball had spun behind the line before being clawed away.
Celtic got back on the front foot and O’Riley forced a good save from a first-time strike before getting back to make an important interception to foil a counter-attack.
The start of the second half was finely-balanced. Felipe Anderson failed to make the most of receiving the ball in yards of space inside the Celtic box before the home side came close from a free-kick. Provedel made a good stop from Reo Hatate’s low drive and Johnston fired over from the rebound.
Cameron Carter-Vickers made his comeback from a hamstring injury after a seven-week lay-off when he replaced Nat Phillips while Palma came on for Yang, who had enjoyed some good moments but generally failed to make the most of his possession.
Hart got down well to save Daichi Kamada’s 20-yard drive before Paulo Bernardo snatched at a half-chance at the other end moments after coming on.
Celtic continued to make the running. Palma was briefly bearing down on goal before Alessio Romagnoli slid in to win the ball, Liam Scales attempted an overhead kick which flew over and Furuhashi was denied from close range.
Palma thought he had scored what would have been one of the best-worked goals in the Champions League this week after a lengthy passing move that went from back to front and side to side.
The Honduran winger was booked for taking his shirt off in celebration before the VAR team delivered worse news, and a crushing blow would soon follow to leave Celtic bottom of their group without a point.
Liverpool 1-0 Real Betis: Szoboszlai gets Slot era up and running
Dominik Szoboszlai's goal was the difference as Arne Slot's first game in charge of Liverpool with spectators present ended in a 1-0 win over Real Betis in Pittsburgh.
Liverpool lost 1-0 in a behind-closed-doors meeting with Preston North End last week, but they were victors in sweltering conditions when their pre-season tour of the United States got under way on Friday.
Szoboszlai scored the only goal after 34 minutes, stroking his finish past Adrian after Mohamed Salah slipped a pass through to the Hungary international.
That goal came four minutes after Curtis Jones was forced off through injury, being replaced by 17-year-old Trey Nyoni.
Former Reds goalkeeper Adrian denied Conor Bradley as a strong Liverpool side chased a second, while Harvey Elliott nodded wide from a Kostas Tsimikas cross.
After Slot rang the changes with 63 minutes gone, Kaide Gordon missed Liverpool's best chance to make it 2-0 by dragging his effort wide, but it did not matter as a controlled performance saw the Reds home.
Data Debrief: Reds in cruise control
Slot had been expected to bring a slightly more measured approach than the "heavy metal football" preached by his predecessor Jurgen Klopp, and that was on full display on Friday as Betis were held at arm's length.
Liverpool enjoyed 62.7% of the possession throughout the match, though Slot will be looking for more penetration when they face Arsenal in the next game of their tour on Wednesday, having only recorded 12 touches in the penalty area to Betis' 10.
Sessegnon rejoins boyhood club Fulham after Tottenham departure
Ryan Sessegnon has resigned for Fulham on a free transfer, five years after leaving the club.
The 24-year-old signed a two-year contract with the Cottagers with the option to extend for a further year following his departure from Tottenham last month.
In his first spell at the club, Sessegnon worked his way through the academy over 11 years, scoring 25 goals in 120 first-team appearances.
He then moved to Spurs in a £25million deal in 2019, though struggled to nail down a place in North London, making just 57 appearances in all competitions, and scoring three goals.
"It's amazing to be back. Emotional, as well," he told FFCtv. "It's where it started for me, where everything began, and it's amazing to be back.
"It will always be home for me. I think it had the feeling that it was meant to be, coming back here, so I'm delighted to get it done."
Sessegnon is Fulham's first signing of the transfer window, though they have seen plenty of first-team departures already, with Joao Palhinha, Tosin Adarabioyo and Bobby De Cordova-Reid all leaving the club.
Dewsbury-Hall: Maresca will surprise people at Chelsea
Kiernan Dewsbury-Hall believes new Chelsea manager Enzo Maresca will "surprise a lot of people" when they watch the Blues this season.
The Italian led Leicester City straight back to the Premier League as Championship winners in his only season in charge and succeeds Mauricio Pochettino at Stamford Bridge.
The Foxes topped the second division table with 98 points, with Dewsbury-Hall a key figure in his squad as he netted 12 goals and provided 14 assists last season – his best tally in a single campaign.
Dewsbury-Hall was also named Leicester's Player and Players' Player of the Year.
The midfielder made the switch to West London earlier this month for £30million and is confident that Maresca will have Chelsea challenging for trophies in no time.
"The manager was a big catalyst in wanting me to come," Dewsbury-Hall told BBC Sport.
"I knew from Leicester, a club that went down and had a lot of problems, how he managed to galvanise that if everyone manages to buy into the system.
"I genuinely think in a short space of time we can be pushing for minimum top four - but more than that.
"He may be unknown for a lot of people, but he is top, top level. He will surprise a lot of people."
Chelsea's pre-season got off to a frustrating start as they were held to a 2-2 draw by League One side Wrexham in Maresca's first game in charge on Wednesday.
Dewsbury-Hall did not play in that match but is training with the squad in the United States and could feature in their next outing against Celtic on Saturday.
The 25-year-old is confident the manager's tactics will come across soon, with the players buying into his style.
"We've only been doing it for two or three weeks, but the combination plays are really quick and tidy," he added.
"That's after two weeks. I remember he said to us at Leicester after six months or a year, there might be teething problems at the start, but it will improve.
"Within the first week at Leicester, I was convinced this was top, top level. I felt a bit stupid; I thought I knew a lot about football, but he was teaching me things on a daily basis that I didn't really know before. He has an aura, he can be strict, or gentle and soft - he has both sides.
"I am getting the same feedback here with the lads. They've bought into it here from minute one which is exciting. With a system and philosophy, you need everyone to buy in because, if they do, you can really achieve something."
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