Southampton have already been relegated from the Premier League, but the race to avoid joining them looks set to go down to the wire.
Two of West Ham, Nottingham Forest, Everton, Leeds and Leicester will play alongside the Saints in the Championship next season.
Here, the PA news agency takes a look at the relegation battle with two games to go.
West Ham (Leeds H, Leicester A)
Given their own plight and their opposition in the final two rounds of fixtures, West Ham will play a deciding role in who goes down. It will take an extraordinary set of results for them to be relegated as they are six points clear of Leeds with a significantly better goal difference, so would need to lose both games heavily and see a number of other results go against them. Their only concern will be how their European exertions affect them, with their match against Leeds coming days after a Europa Conference League semi-final second leg against AZ Alkmaar.
Nottingham Forest (Arsenal H, Crystal Palace A)
Seven points from the last four games has hauled Forest out of the bottom three and they now could stay up even if they lose their remaining fixtures. Safety will be assured if they draw with Arsenal at the City Ground and then Leeds lose at West Ham and Leicester fail to beat Newcastle. However, two defeats, including on the final day at Crystal Palace, and results going against them elsewhere would see them drop back into the Championship.
Everton (Wolves A, Bournemouth H)
Everton, on paper, have the kindest fixtures of those in the fight and they will fancy their chances of staying up, with their Bank Holiday win at Brighton last week looking pivotal. They will confirm their survival if they win at Wolves and then Leeds lose at West Ham and Leicester fail to beat Newcastle. Two defeats could be enough for Leeds to overtake them by drawing just one of their two games, although that will be dependent on a minor goal difference swing.
Leeds (West Ham A, Tottenham H)
Leeds are relying on other teams to lose, but they also have to do their own business under Sam Allardyce, with so many permutations still possible. The most worrying one is they will be sent back to the Championship if they lose at West Ham, Everton win at Wolves and Forest pick up a positive result against Arsenal. But, as mentioned, they could stay up by drawing just one game, if Everton and Leicester lose both of their matches. They will be hoping to take advantage of West Ham’s European distraction as Allardyce visits his old club on Sunday before a vital home game against Tottenham.
Leicester (Newcastle A, West Ham H)
Leicester, Premier League champions seven years ago, could be relegated if they fail to beat Newcastle on Monday night, Forest pick up a point against Arsenal and Everton beat Wolves. Defeat at St James’ Park would also mean Everton would only need two points from their final two games. To stay up, Leicester realistically need to win at least one of their remaining games at Newcastle or at home to West Ham, although it is possible two draws could be enough.
'Right guy at the right time' - Amorim confident of changing Man Utd's fortunes
Ruben Amorim believes he is the "right guy at the right time" to turn Manchester United's fortunes around.
The 39-year-old signed a two-and-a-half-year deal earlier this month to keep him at Old Trafford until June 2027, replacing Erik ten Hag after he was sacked in October.
Amorim is the sixth permanent United manager since Alex Ferguson retired in 2013, having left Sporting CP to take charge during the international break.
He won two Primeira Liga titles as Sporting head coach as well as two Taca da Liga trophies, while he led the club to a perfect start in the league this season, winning all 11 of their games.
United sit 13th in the Premier League table ahead of their trip to Ipswich Town on 15 points, though they are just four points behind Chelsea in third.
Amorim recognised the size of the task ahead of him in Manchester but is confident he can make a change.
"I'm a little bit of a dreamer and I believe in myself, and I believe in the club," he said during his first press conference.
"I think we have the same idea, the same mindset and that can help.
"I truly believe in the players; I know you don't believe a lot, but I do. I want to try new things. You guys don't think it's possible, I do.
"Call me naive, but I believe I am the right guy at the right time. I truly believe I am the right guy."
Aged 39 years and 302 days, Amorim will be the youngest to take charge of his first match for the Red Devils since Wilf McGuinness in August 1969 (31y 288d).
United have won just four of their 11 league games so far this season, and have struggled in front of goal, netting just 12 times so far.
Expected to implement his favoured 3-4-3 formation, Amorim admitted it would take time for the club to adapt and has asked for patience as the players get used to his tactics.
"I know at Manchester United we have to win games. We need a lot of time because it's a tough league, we have to improve a lot to try to win the title," he added.
"We have to change the physical aspect of the team. I don't know how long it will take."
'It's a shame' - Alonso confirms Leverkusen's Boniface out with thigh injury
Bayer Leverkusen boss Xabi Alonso confirmed that Victor Boniface will be sidelined for some time after picking up a thigh injury on international duty with Nigeria.
Boniface, who has scored eight goals in 15 appearances in all competitions this season, was replaced late on in the Super Eagles' 2-1 defeat to Rwanda on Monday.
It is another blow for Leverkusen, who have managed 17 points from 10 games so far this season, the worst start to a league campaign in 12 years by a defending champion.
Only Omar Marmoush and Harry Kane (both 11) have scored more goals in the league than Boniface this term (six).
Alonso revealed that the 23-year-old will miss Saturday's Bundesliga encounter against Heidenheim and their Champions League tie against RB Salzburg next week.
"We will have to see how long he will be out. It is a shame," Alonso told a press conference.
"He has a thigh injury. For tomorrow, for Salzburg and maybe a bit longer. We will have to wait and see.
"It is too early to say but we hope he can still play this year. We have to see with the recovery and improvement but it is not a matter of six or eight weeks."
Leverkusen have dropped points in six Bundesliga games already this season (D5, L1), as often as they did during the entirety of their 2023-24 title-winning campaign (D6).
They come into this weekend's fixture against Heidenheim on a three-game winless run in the Bundesliga (D3), the first time they have gone this long without a victory since between April and May 2023 (five games).
Leverkusen sit fourth in the Bundesliga, already nine points behind leaders Bayern Munich as the busy festive schedule kickstarts on Saturday.
Alonso's side have eight games in just under a month, including a DFB-Pokal round of 16 clash with Bayern at the start of December.
"Eight games in four weeks. It is nothing new for us," Alonso said. "An intense phase is coming up for us and it starts tomorrow.
"We have clear goals for the Bundesliga, the Champions League and the German Cup."
Object thrown at City striker 'Bunny' Shaw in Champions League win over Hammarby sparks UEFA investigation
UEFA has opened an investigation after Manchester City striker Khadija Shaw was hit by an object during their Women’s Champions League win against Swedish side Hammarby on Thursday.
The towering Jamaican striker scored both goals in City’s 2-1 win at the Stockholm Arena to see her side through to the quarterfinal stage.
Her animated celebration in front of the home fans after her first goal saw the 27-year-old being booked, with replays also showing an object seemingly thrown her way from the stands.
“Proceedings have been opened against Hammarby IF for throwing of objects (Article 16(2)(b) of the Disciplinary Regulations),” UEFA said in a statement.
“Manchester City player Khadija Shaw received a yellow card following her goal presentation for unsporting conduct,” the statement added.
Following the game, City captain Alex Greenwood chided match broadcaster DAZN for failing to mention the incident in a social media post.
The post on X, external said Shaw “antagonised” the home fans and received “stick” from them.
Greenwood replied, "Correction. Travel to Stockholm, score a big goal. Celebrates her goal. Gets objects thrown at her.”
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