David De Gea’s slip loosened Manchester United’s grip on the final Champions League place as they were beaten 1-0 at West Ham.
De Gea let Said Benrahma’s hopeful shot from 20 yards slip over his glove to condemn Erik Ten Hag’s side to back-to-back defeats.
They now lie just one point ahead of a rapidly advancing Liverpool, albeit with a game in hand.
But an eighth defeat on the road this season could prove as costly for the visitors as it was priceless for West Ham, who climbed seven points above the relegation zone and are surely now safe.
De Gea’s evening began inauspiciously when his poor clearance flew to the feet of Declan Rice, whose run into the area was only curtailed by a last-ditch tackle from Wout Weghorst.
Marcus Rashford curled over for the visitors while Bruno Fernandes and Antony fizzed low shots narrowly wide.
Christian Eriksen’s effort also floated too high before Rashford cut inside Thilo Kehrer and crashed his shot against the outside of the near post.
The goal arrived in the 29th minute and it is not one De Gea will want to see again.
Benrahma had few options as he drove forward with Aaron Wan-Bissaka, Victor Lindelof and Luke Shaw for company.
The Algerian tried his luck from 20 yards but his shot lacked any real menace and De Gea should have made a routine save.
But the ball seemed to spin away from the Spaniard as he attempted to push it away, and instead it rolled almost apologetically into the net.
Ten Hag’s men tried to hit straight back and Antony’s shot flicked the heel of Nayef Aguerd before clipping the far post.
But the visitors had a lucky escape in first-half stoppage time when Benrahma broke through again.
De Gea saved the winger’s initial shot and his attempt to turn the rebound back into the box clearly hit the hand of Lindelof.
If anything the Swedish defender got a better hand to it than his goalkeeper did for the goal, but the penalty appeals were waved away with the VAR apparently seeing nothing untoward.
United got away with another after the break when De Gea went down as he was challenged by Michail Antonio, the West Ham striker hooking the ball in only to be pulled up for a foul.
Weghorst had United’s first shot on target as the hour mark approached, a tame effort from the edge of the box which was straight at Lukasz Fabianski.
But West Ham, eager to put their relegation worries to bed with a Europa League Conference semi-final to look forward to, sensed something special and Tomas Soucek’s volley hit a post before the Czech midfielder’s header was ruled out for offside.
Fabianski made late saves from Rashford and Anthony Martial but Ten Hag’s side offered little in their 57th match of a gruelling season which, along with Liverpool, might just be catching up with them.
Silva grateful Fulham's dominance was rewarded with late win
Marco Silva believes Fulham claimed a "deserved win" against Brentford, though admits they should have secured the three points much earlier in their 2-1 victory.
It looked like Vitaly Janelt's 24th-minute strike against the run of play was going to wrap up all three points for Brentford, but Harry Wilson proved the Cottagers' hero off the bench, scoring twice in stoppage time to snatch the three points.
Fulham had dominated from the first whistle and had 26 shots, 12 of which were on target, though they struggled to find a way past their opponents' staunch defence until the 92nd minute.
Wilson became just the sixth player to score an equalising and match-winning goal from the 90th minute onwards in the Premier League, while his second goal was Fulham's latest-ever Premier League winner at 96:46.
Silva was delighted with how his team pushed until the final seconds to ensure they came away with a win.
"It was definitely a deserved win. We started on the front foot and dominated all the game. In the first 20 minutes, we had two clear chances to score," Silva told BBC Sport.
"After they scored, we didn't lose the confidence and the trust in ourselves, we kept pushing them back, and we created enough to not be losing at half-time.
"I told the players this is football, it can happen, but we have to keep pushing, working hard and playing our way.
"It was late, it should've been much before, but that's football."
Brentford, meanwhile, have now dropped a league-high 14 points from winning positions in the Premier League as they suffered a fifth consecutive away defeat in the competition.
In fact, they are the first side in the competition's history to score the first goal in four consecutive away games and lose all four.
They had defended resolutely until their late lapse in concentration, and even had a chance to win it, only for Bernd Leno's impressive save to keep out Fabio Carvalho in the 95th minute.
Thomas Frank, though, admitted he was not yet ready to take the positives from the performance after the disappointment of their late defeat.
"It was tough. It is emotionally very tough right now," Frank told Sky Sports.
"When you are leading in the 92nd minute, and you lose, it is tough. I don't think we hit our highest level. I think on the day Fulham were better.
"There was a lot of good defending and effort, and I thought that would have given us the win. We could have won it with the chance for Fabio Carvalho and then we lost.
"When we look at the game back, and we are more cool-headed, we will probably be very happy with the defensive standard. I thought there were unbelievable blocks, and recovery runs and all that we did well. On the ball, we didn't do enough."
Fulham 2-1 Brentford: Wilson's late brace seals comeback win
Harry Wilson scored twice in stoppage time as Fulham came back to beat Brentford 2-1 in an enthralling West London derby.
Wilson was the hero from Fulham's bench on Monday, as Marco Silva's team – who were on the wrong end of a late comeback against Everton last time out in the Premier League – salvaged a victory from the jaws of defeat.
Fulham will feel it was a win they earned from a match they dominated from the off, with the Bees having taken the lead against the run of play through Vitaly Janelt's stunning 24th-minute strike.
But the Fulham pressure finally told when Wilson rose high to flick in his first in the 92nd minute, and – after Bernd Leno made a superb stop to thwart Brentford at the other end – the former Liverpool midfielder nodded in again to send Craven Cottage into raptures.
Fulham's win takes them up into ninth, while Brentford drop to 12th after suffering a fifth league loss of the season.
Data Debrief: Super-sub Wilson to the rescue
Fulham will feel they deserved to come away from that match with three points, having had 26 shots, 12 of which were on target, in an incredibly dominant display.
They also had 46 touches in the opposition box compared to Brentford's nine, but they could not make those count, at least until Wilson's late intervention as he finally broke through Brentford's stubborn defence.
The Welshman scored with both of his shots on target, having three attempts overall, with his goals coming from a combined 0.19 expected goals.
The Bees looked sure to get a first away win, and first clean sheet, of the Premier League season until their late lapse in concentration, and they have now dropped 14 points from winning positions in the competition this season, more than any other team.
Arsenal sporting director Edu steps down
Arsenal have confirmed Edu has resigned from his role as the club's sporting director.
Edu, a former Arsenal player who was part of the "Invincibles" squad in the 2003-04 season, has been involved in the behind-the-scenes running of the Gunners since July 2019.
He first returned to the club as technical director, and was promoted to sporting director in November 2022.
Edu has played a key role in supporting Mikel Arteta, and helping the Spaniard transform the Gunners into Premier League title contenders.
Reports emerged on Monday, however, that the Brazilian was quitting his role, with speculation mounting that he will be joining Evangelos Marinakis' footballing organisation - the Greek magnate owns Nottingham Forest and Olympiakos.
"This was an incredibly hard decision to make," Edu said in a statement released on Arsenal's website.
"Arsenal has given me the opportunity to work with so many amazing people and the chance to be a part of something so special in the club’s history. It has been a special journey.
"I've loved working with so many great colleagues across our men’s, women’s and academy teams, especially Mikel, who has become a great friend.
"Now it is time to pursue a different challenge. Arsenal will always remain in my heart. I wish the club and its supporters only good things and all the very best."
The news comes after Arsenal were beaten 1-0 by Newcastle United on Saturday to leave them seven points adrift of Premier League leaders Liverpool.
Arsenal face Inter in the Champions League on Wednesday.
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