Manchester City put pressure on Premier League leaders Arsenal ahead of their trip to Liverpool on Sunday with an emphatic 4-1 victory at Southampton.
Erling Haaland's double took him to 30 Premier League goals in 27 games, just 70 shy of Son Heung-min's career total in his eighth season in England after the South Korea international made history on Saturday.
The race for the other top-four places behind Arsenal and City saw Manchester United and Newcastle United both win, while Tottenham remain three points back after riding their luck against Brighton and Hove Albion.
Stats Perform looks at some of the more notable Opta numbers to come out of the pick of Saturday's Premier League action.
Manchester United 2-0 Everton: Wasteful Red Devils still win comfortably
After goals from Scott McTominay and Anthony Martial either side of half-time, United have won 39 Premier League games against Everton, the joint-most one side have against another in the competition's history (also 39 wins for United against Spurs).
Erik ten Hag's men have won 23 of their 28 home games in all competitions this season (D3 L2), their highest total of wins in a single campaign at Old Trafford since 2010-11 (26).
As they continue to fight relegation, Everton have won just one of their last 17 away Premier League games (D7 L9) and remain winless on the road since a 2-1 victory at Southampton in October (11 games since).
McTominay's strike was his fifth in five games for club and country, as many as in his previous 106 appearances for United and Scotland combined.
Ten Hag bemoaned his side's wastefulness as United failed to convert seven big chances – six of which came in the first half – their joint-highest total on record (since 2010-11) in a league match (also seven vs Sunderland in December 2012).
Brentford 1-2 Newcastle United: Bees stung by Magpies
Brentford started well in this one but ultimately failed to win a Premier League game in which they had opened the scoring for the first time (P26 W19 D6 L1), while Newcastle have lost just one of their last five away league games in which they have conceded first (W2 D2), winning the last two.
Eddie Howe has won exactly 100 Premier League points as Newcastle boss (P56 W28 D16 L12), with only fan favourite Kevin Keegan needing fewer games (51) to reach that milestone.
Ivan Toney became just the fourth player to score home and away against Newcastle in a Premier League campaign having previously played for them in the competition, following Louis Saha (2001-02), Craig Bellamy (2008-09) and Abdoulaye Faye (2008-09).
Before netting from the spot, though, Toney failed to score a penalty for the first time since October 2018 for Peterborough United against Barnsley when he saw his first effort saved by Nick Pope, having scored 24 successive penalties before Saturday (excluding shoot-outs).
A David Raya own goal drew Newcastle level, then Alexander Isak scored his eighth Premier League goal to take the points. Seven of those have either drawn Newcastle level (two) or given them the lead (five).
Tottenham 2-1 Brighton and Hove Albion: Son reaches landmark while Seagulls are left to fume
Brighton suffered their first defeat in eight Premier League games on the road (W4 D3) since a 3-1 defeat to Manchester City in October, although they will be tempted to lay a lot of the blame at the door of the officials.
Seagulls boss Roberto Di Zerbi was furious with two goals being ruled out for alleged handballs, while Kaoru Mitoma was also denied what looked like a very good shout for a penalty. The Italian then became the first manager to be sent off twice in the Premier League this season. Cristian Stellini was also dismissed.
For Son, though, it was a landmark day as his terrific opener made him the first Asian player to score 100 Premier League goals, while he is just the 10th player in the league's history to score 100 goals and register 50 assists for one team – and the first to do so for Spurs.
Lewis Dunk equalised in his 200th Premier League appearance, with each of the last four players to mark that milestone in such a way now having been centre-backs (also Kurt Zouma, Virgil van Dijk and Ben Mee).
But after the controversy at the other end, Harry Kane won it for Tottenham with his 10th goal in 12 appearances for the club against Brighton in all competitions. The Seagulls are the ninth team he has reached double-figures against in his career, along with Leicester City, Everton, Arsenal, Southampton, West Ham, Burnley, Crystal Palace and Stoke City.
Southampton 1-4 Manchester City
Kevin De Bruyne was back to his sensational best at St Mary's, registering his 100th Premier League assist, making him the fifth player to reach that mark and doing so in fewer appearances (237) than any of the previous four.
Haaland's brace, including an outrageous bicycle kick, meant he has scored 44 goals in all competitions for City this season – the joint-most ever by a Premier League player in a single campaign, level with Ruud van Nistelrooy (2002-03) and Mohamed Salah (2017-18).
De Bruyne laid on the opener and has assisted seven Premier League goals for Haaland this season, the most one City player has ever assisted for another in a single campaign.
Jack Grealish teed up the other Haaland goal and also got on the scoresheet. He has now been involved in 10 goals in 15 league games since the World Cup (four goals, six assists). Only Haaland (14) has been involved in more for Pep Guardiola's team in that time, while it is three more than Grealish managed in his first 34 appearances for City (four goals, three assists).
Julian Alvarez replaced Haaland and dispatched a second-half penalty, becoming the fifth different City player to score as a substitute in the Premier League this season, with only United and Wolves (six) having more.
St. Louis City v LA Galaxy: Reus sets sights on silverware after dream start
Marco Reus is desperate to bring silverware to the LA Galaxy after making a flying start to his time in MLS, with St. Louis City the destination for his first road game on Sunday.
Reus registered a goal and an assist on debut last week as the Galaxy beat Atlanta United 2-0, maintaining their grip on top spot in the Western Conference.
The Galaxy are five points clear of local rivals Los Angeles FC at the top of the standings ahead of Sunday's trip to St. Louis, who are 13th and 10 points adrift of the playoff picture.
Reus' arrival in Los Angeles has caused plenty of fanfare, but he is focused solely on the team's collective aims.
"It's not about me, it's about the team," he said. "We want to be champions. So we take it game by game.
"Besides the traffic, it's really amazing. The people are so friendly. The weather, it's really nice. When you wake up in the morning and the sun is shining, you start the day differently.
"So I'm really, really happy every morning I come into the dressing room. I'm just happy and excited."
St. Louis played out a thrilling 4-4 draw with the Portland Timbers last week, twice throwing away a two-goal lead to leave interim coach John Hackworth bewildered.
"Really don't know what to say," Hackworth said. "It's hard to imagine coming to a place like this and scoring four goals, being up, and then just losing one-versus-one defensive battles.
"Sometimes, the number of goals you give up, or the number of goals you score, can hide a lot of the transition moments.
"An easy way to prevent some of these defensive miscues from happening is to just be better with the ball."
PLAYERS TO WATCH
St. Louis City – Eduard Lowen
Lowen scored his fourth goal of the MLS season last time out, converting from the penalty spot as St. Louis drew 4-4 with the Timbers.
Only Joao Klauss, with five goals, has outscored him for St. Louis this term.
LA Galaxy – Marco Reus
Reus is one of 20 players in MLS history to record a goal and an assist on his regular-season debut.
He is also the fifth Galaxy player to do so, after Steven Gerrard, Andreas Herzog, Giovani dos Santos and Sasha Victorine. No other team have had more than two players achieve the feat.
MATCH PREDICTION – DRAW
The Galaxy have won 10 of their last 13 regular-season matches, the first time they have done so in a single season since 2011. LA have not recorded 11 wins in a span of 14 matches within a single regular season in the post-shootout era (since 2000).
It would be no surprise to see the points shared in this one, though. All three meetings between St. Louis and the Galaxy have ended level, all with different scorelines (1-1, 2-2, 3-3).
St. Louis have only won one of the last six matches in which they have held the lead in regular-season play dating back to the beginning of June (four draws, one defeat).
OPTA WIN PROBABILITY
St. Louis City – 35.8%
LA Galaxy – 38.1%
Draw – 26.1%
Raphinha hails Barcelona after statement win over Valladolid
Barcelona forward Raphinha believes the team have laid down a statement of their intent by starting the season with four straight wins in LaLiga.
Raphinha scored the first hat-trick of his career and also delivered two assists on Saturday, as Barca crushed Real Valladolid 7-0 at Camp Nou.
Hansi Flick's side already possess a four-point cushion at the top of the table after also recording victories over Valencia, Athletic Bilbao and Rayo Vallecano.
Raphinha believes their results have demonstrated the club got things right in the transfer market, telling Movistar: "Today's game has shown that there is no need for anyone else to come. We are very happy because of that.
"We are in very good shape. The team is working hard. Today's result shows what we are working for.
"We saw that the coach was on the sidelines asking for more goals and that's our mentality.
"We are hungry and want to score as many goals as we can. When we are dominant like we have been, the best way to respect our rivals is not taking the foot off the gas."
Raphinha was one of the players who faced criticism during Barca's trophyless 2023-24 campaign and was rumoured to be on his way out ahead of the new season.
The Blaugrana again battled financial restrictions throughout the window, allowing Ilkay Gundogan to leave in order to secure the registration of new arrival Dani Olmo.
With his future now certain, Raphinha is keen to nail down a starting spot and contribute on a regular basis.
"I don't know if today's was my best game, but it's certainly among my best. I will try to play even better and as much as I can," the Brazilian said.
"I'm very happy to be able to help the team. I feel good. I knew that this season would be very important for me. I'm looking for my best version to help my team-mates and be more confident."
Lazio 2-2 Milan: Leao salvages draw but Rossoneri still winless
Rafael Leao came off the bench to earn Milan a 2-2 draw with Lazio at the Stadio Olimpico on Saturday, but Paulo Fonseca's side are still without a Serie A win this season.
Milan were in front at the break through Strahinja Pavlovic's eighth-minute goal, the Serbian rising highest to power home a header from Christian Pulisic's corner.
However, Lazio hit back in the second half with Valentin Castellanos and Boulaye Dia scoring in quick succession.
Nuno Tavares' first-time ball into the centre was met by the unmarked Castellanos to level in the 62nd minute, then Dia tapped another Tavares cutback home to put the Biancocelesti ahead four minutes later.
Fonseca reacted by sending on four substitutes, and those changes had a swift impact as three of them combined for the leveller.
Theo Hernandez – who joined Leao in being dropped from the start – picked out Tammy Abraham, and his lay-off allowed Leao to escape Tavares to fire past Ivan Provedel.
The game was preceded by an emotional tribute to the man who led Lazio to their last league title, Sven-Goran Eriksson, who died at the age of 76 on Monday.
A Lazio shirt bearing the Swede's name was displayed on the home bench, while a banner held up by the home fans read: "You brought us to the top of the world... Have a good trip Mr. Sven."
Data Debrief: Milan's slow start continues
New Milan boss Fonseca is already under pressure after overseeing a return of two points from his first three league games at the helm.
It is the first time the Rossoneri have drawn two of their opening three matches in a Serie A season since 2011-12, when they also drew two and lost one,
They went on to finish second that season, just four points adrift of champions Juventus. If a title challenge is to take place this term, rapid improvements are needed.
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