Arsenal manager Mikel Arteta is unsure if Takehiro Tomiyasu will return from injury this season, though he is hopeful the Gunners will receive more positive news on fellow defender William Saliba.
Tomiyasu and Saliba were both forced out of Arsenal's Europa League last-16 second leg against Sporting CP – which Arteta's men eventually lost on penalties – with injuries on Thursday.
Both men were then absent as Arsenal established an eight-point lead at the Premier League summit on Sunday, thrashing managerless Crystal Palace 4-1 on a weekend when title rivals Manchester City were on FA Cup duty.
Asked after that win whether Tomiyasu's knee injury could rule him out for the rest of the campaign, Arteta said: "We don't know, obviously the doctor is assessing him.
"We've had one assessment, they need to have another assessment tomorrow, but it's not looking good, that's for sure.
"Looking at Tomi, he's not someone who exaggerates things. He was really concerned straight away, and we are concerned."
Reports have suggested Saliba may be forced to withdraw from France's squad for their upcoming Euro 2024 qualifiers against the Netherlands and the Republic of Ireland, but Arteta hopes he will not miss a significant portion of Arsenal's run-in.
Rob Holding made his first start of the Premier League season against Palace, and Arteta says more fringe players will need to step up as the Gunners chase their first title since 2004.
"We hope Willy is going to be better news, but again we have to wait until [Monday] to understand a better picture," he said.
"We have lost players – we lost Gabby [Gabriel Jesus] for four months; we lost Thomas [Partey] for one and a half months; we lost Oleksandr Zinchenko for one and a half months.
"We lost [Mohamed] Elneny for six to eight months; we lost Eddie [Nketiah], and now we lost Tomiyasu and Saliba. Everybody has to give more.
"It's not a secret, if we want to maintain that level, everyone has to step in, give more, and Rob is a great example of what we needed today."
Chelsea 2-0 Tottenham: Chalobah and Jackson goals dent Spurs' top-four hopes
Trevoh Chalobah and Nicolas Jackson scored as Chelsea dealt a huge blow to Tottenham's Champions League hopes, recording a 2-0 derby win over Mauricio Pochettino's old club at Stamford Bridge.
Exactly eight years on from the memorable "Battle of the Bridge" between the teams, which saw nine Spurs players booked in a fiery 2-2 draw that confirmed Leicester City as champions, Chelsea inflicted more woe upon their rivals.
Spurs paid for lacklustre set-piece defending midway through the first half as Chalobah headed Conor Gallagher's free-kick home, then Jackson pounced when Cole Palmer rattled the crossbar from another dead ball 72 minutes in.
Ange Postecoglou's side were far from their free-flowing best and have now lost three straight Premier League games. They stay fifth, seven points behind fourth-placed Aston Villa with just one game in hand.
Chelsea, meanwhile, climb above West Ham into eighth, just three points adrift of Manchester United in sixth.
The Blues went agonisingly close to a fifth-minute lead as Jackson raced through on goal to slot his effort under Guglielmo Vicario, but Micky van de Ven raced back to hook it off the line and Palmer could not sort his feet out on the rebound.
Chelsea were ahead after 24 minutes, though, as Chalobah met Gallagher's deep free-kick with a looping header into the top-right corner, the goal being confirmed by VAR following a check for a possible foul by Marc Cucurella.
Mykhailo Mudryk went close with a curling effort as Tottenham continued to toil, the visitors' best chance of the first half coming when Cristian Romero headed Pedro Porro's free-kick wide.
Ange Postecoglou cut an animated figure before half-time, and his side improved after the restart, but Chelsea could have had a second when Palmer shot over at the end of a promising break.
Chelsea did double their advantage with 18 minutes to play, the opportunistic Jackson heading into an unguarded net after Palmer's free-kick clattered off the woodwork with Vicario at full stretch.
Tottenham never looked like responding from there, and they now need a minor miracle to secure a top-four finish.
Pochettino haunts former employers
Having also overseen Chelsea's memorable 4-1 win in November's return fixture at the Tottenham Hotspur Stadium, Pochettino completed a league double over his former employers.
He is the first coach to ever beat Spurs home and away in a single Premier League campaign having previously managed them in the competition.
The Argentine's first season at Stamford Bridge may not have gone entirely to plan, but there may just be green shoots of recovery emerging in the closing weeks of the campaign.
Having endured a run of one win in 14 home Premier League games between March and November last year (seven draws, six losses), Chelsea – who face West Ham next – have now won eight of their last 10 on their own turf (one draw, one defeat).
Set-pieces costing Spurs
Tottenham have a set-piece problem. Arsenal ruthlessly exploited some slack marking from their neighbours to score two goals from corners in Sunday's north London derby, and on Thursday, it was two free-kicks that undid Postecoglou's men.
Prior to this game, Spurs had conceded 12 goals from set-pieces, excluding penalties, in the Premier League this season. Only Manchester United (15.3) and Burnley (14.9) had allowed opponents a higher cumulative expected goals (xG) figure from such situations than their 14.3.
They did not learn their lesson, Emerson Royal and Brennan Johnson getting nowhere near Chalobah as he headed home from a routine delivery to the back post for the opener.
Those fine margins could prove incredibly costly, with Tottenham now a long way adrift of top-four rivals Aston Villa with daunting fixtures against Liverpool and Manchester City still to come.
Nuno demands Premier League resolves PSR 'mess' as Forest await appeal verdict
Nuno Espirito Santo has called for the Premier League to provide clarity as Nottingham Forest wait on their appeal against a four-point deduction for breaching profit and sustainability rules, describing the situation as a "mess".
Forest were deducted four points in March after being found to have breached the competition's financial rules in the assessment period culminating in the end of the 2022-23 season.
Everton have also had a total of eight points deducted for two separate breaches, but with the Toffees pulling clear of the relegation zone, it is Forest who are looking over their shoulders.
Nuno's team sit just one point clear of 18th-placed Luton Town as they await the outcome of an appeal against their penalty, and he says the lack of clarity is affecting several clubs.
Asked whether he had received an update on Forest's appeal on Thursday, Nuno said: "Unfortunately we haven't heard yet.
"We are expecting to, but not yet. It is very difficult. We have been dealing with this situation for a while.
"We all expected the decision to come sooner, so we would know exactly how many points we have. Do we have 30, 29, 28, 27? We need it as fast as possible.
"To have 30 points would be fantastic, because this is the number of points that the boys achieved on the pitch.
"It is a mess. It should have been decided before. They have had enough time. It is very difficult for us but also for the rest of the league. It is very hard to be in this situation."
Forest visit already-relegated Sheffield United on Saturday, having taken just one point from four Premier League games since beating Fulham 3-1 in early April.
They could be in the relegation zone by the time that match kicks off, with Luton hosting Everton in a huge clash at Kenilworth Road on Friday.
France defender Hernandez to miss Euro 2024 after suffering ACL injury
Lucas Hernandez will miss France's Euro 2024 campaign after tearing his anterior cruciate ligament during Paris Saint-Germain's 1-0 Champions League defeat to Borussia Dortmund.
Dortmund will take a slender lead to the Parc des Princes for next week's semi-final second leg after Niclas Fullkrug's strike powered them past PSG in Wednesday's first leg in Germany.
Hernandez sustained a knee injury while chasing after Fullkrug in the build-up to the goal and was substituted after a brief attempt to play on.
On Thursday, PSG announced an MRI scan had revealed an ACL tear in his left knee, which will require surgery in the coming days.
Hernandez, who has 37 senior international caps, will now miss Euro 2024, with France set to open their Group D campaign against Austria in Dusseldorf on June 17.
Didier Deschamps' side then face the Netherlands in Leipzig four days later, before taking on Poland in Dortmund on June 25.
Hernandez was part of France's squad for the 2022 World Cup but sustained another ligament injury during Les Bleus' opening match against Australia, missing the rest of the tournament and not returning to club football until the start of 2023-24.
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