It's fair to say Serie A sides have enjoyed themselves on the continental stage this season, with six Italian clubs reaching major European quarter-finals for the first time this century.
Three of those teams have been making waves in the Champions League, for which Luciano Spalletti's Napoli have been touted as genuine contenders after outscoring every other team in the competition.
Meanwhile, rivals Milan and Inter went about their last-16 assignments in quietly impressive fashion, seeing off Tottenham and Porto respectively, both winning 1-0 on aggregate.
With three of Italy's finest reaching the last eight, a first all-Italian Champions League meeting since 2005 was always highly probable, and so it proved with Milan and Napoli paired together.
With the winner of that tie set to face either Inter or Benfica in the semi-finals, the prospect of a first Italian Champions League winner since Inter's class of 2009-10 has perhaps never appeared more realistic.
Ahead of a blockbuster tie between last season's Serie A winners and their likely successors, Stats Perform looks back at the Champions League's previous all-Italian tussles.
Shevchenko decisive in tight derby double-header
Given the remarkable European pedigree enjoyed by seven-time European Cup/Champions League winners Milan, the fact that the Rossoneri have featured in all five previous all-Italian games in the competition is perhaps unsurprising.
The first two of those came at the semi-final stage in the 2002-03 campaign, when Milan and Inter faced off in a tense double-header ultimately decided by a Rossoneri great.
Milan had reached the last four courtesy of Jon Dahl Tomasson's last-gasp strike against Ajax, while the Nerazzurri edged out Valencia on away goals.
Hector Cuper's men had less luck with that rule against their rivals, with Andriy Shevchenko's 'away' goal deciding a tie which ended 1-1 on aggregate – despite, of course, both legs being held at San Siro.
Inter's Obafemi Martins set up a tense finish after coming on as a substitute, but Carlo Ancelotti's team held on to reach a first final since 1995 – where they would face another domestic rival.
Dida wins battle of the goalkeepers at Old Trafford
Italian football's reputation for being risk-averse has not always been warranted, but given the way 2003's Champions League final between Milan and Juventus played out, that tag is perhaps understandable.
Juve had already edged out both Milan giants to win Serie A by the time they faced the Rossoneri at Old Trafford, for what represented Marcello Lippi's fourth Champions League final with the Bianconeri (winning in 1996, losing in 1997, 1998 and 2003).
Both defences were on top throughout a nail-biting affair, with Shevchenko seeing a goal ruled out for offside and Antonio Conte rattling the crossbar as the game went to a penalty shoot-out.
With both goalkeepers clearly advancing off the goal line for each spot-kick, Gianluigi Buffon saved from Clarence Seedorf and Kakha Kaladze – only for Dida to go one better by denying David Trezeguet, Marcelo Zalayeta and Paolo Montero as Milan won their sixth European crown.
Dida in the spotlight again as violent scenes mar San Siro clash
Dida was again in the spotlight when two Italian sides last squared off in the Champions League – this time for all the wrong reasons.
The 2004-05 quarter-finals featured another heavyweight derby clash between Milan and Inter – who, as was the case two years earlier – finished the Serie A season in second and third respectively as Juventus triumphed.
Milan have always been Italy's European kings, however, and goals from Jaap Stam and Shevchenko put them in the ascendency as Ancelotti's men won the 'home' leg 2-0.
When Shevchenko's first-half effort put the Rossoneri ahead in the return game and Inter – now requiring four goals – saw an Esteban Cambiasso strike ruled out for a foul, the Nerazzurri supporters reacted furiously.
Flares rained down from the stands onto the San Siro pitch, with Dida struck on the shoulder and left requiring treatment for a burn.
Referee Markus Merk attempted to restart the game after a lengthy delay, but when Christian Abbiati was targeted with further missiles, the game was abandoned and Milan were awarded a 3-0 win, making it 5-0 on aggregate and leading to condemnation from across the continent.
From a Milan point of view, the less said about their subsequent trip to Istanbul for the 2005 final against Liverpool, the better.
Lazio 2-2 Milan: Leao salvages draw but Rossoneri still winless
Rafael Leao came off the bench to earn Milan a 2-2 draw with Lazio at the Stadio Olimpico on Saturday, but Paulo Fonseca's side are still without a Serie A win this season.
Milan were in front at the break through Strahinja Pavlovic's eighth-minute goal, the Serbian rising highest to power home a header from Christian Pulisic's corner.
However, Lazio hit back in the second half with Valentin Castellanos and Boulaye Dia scoring in quick succession.
Nuno Tavares' first-time ball into the centre was met by the unmarked Castellanos to level in the 62nd minute, then Dia tapped another Tavares cutback home to put the Biancocelesti ahead four minutes later.
Fonseca reacted by sending on four substitutes, and those changes had a swift impact as three of them combined for the leveller.
Theo Hernandez – who joined Leao in being dropped from the start – picked out Tammy Abraham, and his lay-off allowed Leao to escape Tavares to fire past Ivan Provedel.
The game was preceded by an emotional tribute to the man who led Lazio to their last league title, Sven-Goran Eriksson, who died at the age of 76 on Monday.
A Lazio shirt bearing the Swede's name was displayed on the home bench, while a banner held up by the home fans read: "You brought us to the top of the world... Have a good trip Mr. Sven."
Data Debrief: Milan's slow start continues
New Milan boss Fonseca is already under pressure after overseeing a return of two points from his first three league games at the helm.
It is the first time the Rossoneri have drawn two of their opening three matches in a Serie A season since 2011-12, when they also drew two and lost one,
They went on to finish second that season, just four points adrift of champions Juventus. If a title challenge is to take place this term, rapid improvements are needed.
Napoli 2-1 Parma: Lukaku and Anguissa fire Conte's men to last-gasp win
Romelu Lukaku and Andre-Frank Zambo Anguissa scored in second-half stoppage time as Napoli fought back for a thrilling 2-1 victory over Parma in Serie A.
Newly promoted Parma, who stunned Milan last week, looked set to claim a second surprise win in as many games when Ange-Yoan Bonny won and converted a 19th-minute penalty.
The momentum of the game changed, however, when Parma goalkeeper Zion Suzuki was shown his second yellow card for a foul on David Neres with 15 minutes of the 90 remaining.
With no further substitutions available to the visitors, defender Enrico Del Prato took over in goal and went close to getting his team over the line with a clean sheet intact.
However, new signing Lukaku came off the bench to equalise for Napoli in the second minute of stoppage time, shortly after the Partenopei had seen a penalty overturned following a VAR review.
There was more drama to come at the death as Anguissa headed home in the sixth minute of stoppage time, though Napoli also had to survive one last scare as Pontus Almqvist was denied by Alex Meret at the other end.
Data Debrief: Flying start for Lukaku
Just as Napoli's hopes seemed to be slipping away, up stepped debutant Lukaku to level with a low strike, setting the stage for the most remarkable of comeback victories.
Across the last five Serie A campaigns, Lukaku has 29 goals in 48 home games for Inter, Roma and Napoli. That is the fewest home games required by any player to net over 25 goals in the competition during that span.
Parma, meanwhile, were left to rue the sending-off of Suzuki, who became their first goalkeeper to see red in Serie A since Antonio Mirante against Sassuolo, back in March 2015.
Lopetegui rues missed opportunity as West Ham lose to Man City
West Ham manager Julen Lopetegui was not encouraged by the performance of his team despite losing 3-1 at home to Manchester City in their third league game.
“It is true that City is one of the best teams around the world for sure… but it is also true too that in the second half we have been very close to a draw,” he said speaking to BBC Match of the Day.
“I think we have played one very good second half. The start has been very good for us too.”
West Ham threatened for extended periods of the match and had chances to level the match at 2-1 down, with the best coming from Mohammed Kudus as he smashed a shot against the bar in the second half.
They also started the game brightly before going a goal down inside 10 minutes.
“In my mind we started very well, being aggressive,” said Lopetegui.
“We know in this plan normally they have initiative, it’s very difficult to not concede initiative then. That’s why you have to do a lot of very good things to overcome them.
“In the second half we had chances, I think we kept the ball much more, much more, and didn't concede a lot of chances."
But the hosts were ultimately undone by the brilliant finishing of Erling Haaland, who scored his second hat-trick in as many matches.
“He is one of the best players in the world, that's why he plays for Manchester City,” he said.
“You have to compete with these kind of players. City has the power and the quality to create chances.”
But ultimately, he was left frustrated at the sense of a missed opportunity and that his team were unable to earn themselves a draw that hadn’t seemed implausible during the match.
“Today I think the first goal was a pity for us but I’ve said it. I was happy with the performance think we were able to draw but again they damage us,” he said.
“Against this kind of team, if you make a mistake they don’t forgive. This is the difference they have… A little mistake they punish you, they punish us.
“We have to improve, to know to compete against this kind of team to be close to perfection.
“Don't make mistakes, be calm, defend well… we have quality players too.”
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