The Champions League knockout stages are renowned for delivering high drama, and that will be required if Liverpool and Eintracht Frankfurt are to progress to the last eight.
Both Liverpool and Eintracht face uphill battles to reach the quarter-finals having been comfortably beaten at home in the first legs of their respective last-16 ties.
Eintracht lost 2-0 to Napoli, while Liverpool have the task of overturning a 5-2 first-leg deficit against Real Madrid, the team who beat them in last year's final.
Although you can never count Liverpool out of any tie, the omens are squarely against either trailing side completing a comeback on Wednesday.
Here, Stats Perform previews the final two matches of the last 16 with the help of Opta numbers.
Napoli v Eintracht Frankfurt
Dominant in Serie A, Luciano Spalletti's Napoli already appear destined to claim their first Scudetto since 1990.
Should they finish the job at home in the second leg after victory in Frankfurt, they will make another piece of history.
Indeed, if they do progress, Napoli will reach the quarter-finals of the Champions League for the first time.
Hope for Eintracht comes from the 2011-12 season, the last time Napoli won a Champions League knockout match (3-1 v Chelsea). That was followed by a 4-1 defeat at Stamford Bridge and elimination from the competition.
But Napoli are unbeaten in their last 11 Champions League home games (W8 D3), and the odds of Eintracht stopping the hosts scoring appear slim.
Napoli have scored 22 goals in the Champions League this season – the last time an Italian side netted more in a single campaign (excluding goals in awarded victories, such as Milan in 2004-05) was in 2002-03, with Juventus scoring 30 and Inter netting 26. The form book favours Napoli turning Eintracht's already tough task into an impossible one.
Real Madrid v Liverpool
This will be Madrid's 300th match in the Champions League, at least 20 more than any other side since the 1992 rebrand, and Liverpool have a mountain to climb if they are to ruin the occasion.
Liverpool, of course, do have history of remarkable turnarounds in this competition. The Reds are one of just four sides to have progressed from a Champions League tie having lost the first leg by three or more goals, doing so against Barcelona in the 2018-19 semi-final (0-3 away, 4-0 home).
But Madrid are used to getting the job done at the Santiago Bernabeu. They have progressed from 26 of their previous 27 European Cup or Champions League knockout ties when winning the first leg away from home, with the exception being defeat to Ajax at this stage in 2018-19 (2-1 away, 1-4 at home).
If Liverpool are to deliver another second-leg performance for the ages, they will likely need to slow Vinicius Junior.
Vinicius has scored Champions League braces for Real Madrid against Liverpool at both Anfield and the Alfredo Di Stefano, Madrid's home while the Bernabeu was being renovated.
With this game taking place at the Bernabeu, he could become just the second player to score two or more goals against the same opponents in Champions League games at three different venues – after Cristiano Ronaldo against Juventus (Allianz Stadium, Bernabeu and Principality Stadium).
Having lost six of their last seven Champions League games against Madrid, Liverpool also have the issue of stopping Karim Benzema, who has scored 19 goals in his last 19 appearances in the knockout stages, while he is also the top scorer against Liverpool in European Cup and Champions League history (six).
St. Louis City v LA Galaxy: Reus sets sights on silverware after dream start
Marco Reus is desperate to bring silverware to the LA Galaxy after making a flying start to his time in MLS, with St. Louis City the destination for his first road game on Sunday.
Reus registered a goal and an assist on debut last week as the Galaxy beat Atlanta United 2-0, maintaining their grip on top spot in the Western Conference.
The Galaxy are five points clear of local rivals Los Angeles FC at the top of the standings ahead of Sunday's trip to St. Louis, who are 13th and 10 points adrift of the playoff picture.
Reus' arrival in Los Angeles has caused plenty of fanfare, but he is focused solely on the team's collective aims.
"It's not about me, it's about the team," he said. "We want to be champions. So we take it game by game.
"Besides the traffic, it's really amazing. The people are so friendly. The weather, it's really nice. When you wake up in the morning and the sun is shining, you start the day differently.
"So I'm really, really happy every morning I come into the dressing room. I'm just happy and excited."
St. Louis played out a thrilling 4-4 draw with the Portland Timbers last week, twice throwing away a two-goal lead to leave interim coach John Hackworth bewildered.
"Really don't know what to say," Hackworth said. "It's hard to imagine coming to a place like this and scoring four goals, being up, and then just losing one-versus-one defensive battles.
"Sometimes, the number of goals you give up, or the number of goals you score, can hide a lot of the transition moments.
"An easy way to prevent some of these defensive miscues from happening is to just be better with the ball."
PLAYERS TO WATCH
St. Louis City – Eduard Lowen
Lowen scored his fourth goal of the MLS season last time out, converting from the penalty spot as St. Louis drew 4-4 with the Timbers.
Only Joao Klauss, with five goals, has outscored him for St. Louis this term.
LA Galaxy – Marco Reus
Reus is one of 20 players in MLS history to record a goal and an assist on his regular-season debut.
He is also the fifth Galaxy player to do so, after Steven Gerrard, Andreas Herzog, Giovani dos Santos and Sasha Victorine. No other team have had more than two players achieve the feat.
MATCH PREDICTION – DRAW
The Galaxy have won 10 of their last 13 regular-season matches, the first time they have done so in a single season since 2011. LA have not recorded 11 wins in a span of 14 matches within a single regular season in the post-shootout era (since 2000).
It would be no surprise to see the points shared in this one, though. All three meetings between St. Louis and the Galaxy have ended level, all with different scorelines (1-1, 2-2, 3-3).
St. Louis have only won one of the last six matches in which they have held the lead in regular-season play dating back to the beginning of June (four draws, one defeat).
OPTA WIN PROBABILITY
St. Louis City – 35.8%
LA Galaxy – 38.1%
Draw – 26.1%
Raphinha hails Barcelona after statement win over Valladolid
Barcelona forward Raphinha believes the team have laid down a statement of their intent by starting the season with four straight wins in LaLiga.
Raphinha scored the first hat-trick of his career and also delivered two assists on Saturday, as Barca crushed Real Valladolid 7-0 at Camp Nou.
Hansi Flick's side already possess a four-point cushion at the top of the table after also recording victories over Valencia, Athletic Bilbao and Rayo Vallecano.
Raphinha believes their results have demonstrated the club got things right in the transfer market, telling Movistar: "Today's game has shown that there is no need for anyone else to come. We are very happy because of that.
"We are in very good shape. The team is working hard. Today's result shows what we are working for.
"We saw that the coach was on the sidelines asking for more goals and that's our mentality.
"We are hungry and want to score as many goals as we can. When we are dominant like we have been, the best way to respect our rivals is not taking the foot off the gas."
Raphinha was one of the players who faced criticism during Barca's trophyless 2023-24 campaign and was rumoured to be on his way out ahead of the new season.
The Blaugrana again battled financial restrictions throughout the window, allowing Ilkay Gundogan to leave in order to secure the registration of new arrival Dani Olmo.
With his future now certain, Raphinha is keen to nail down a starting spot and contribute on a regular basis.
"I don't know if today's was my best game, but it's certainly among my best. I will try to play even better and as much as I can," the Brazilian said.
"I'm very happy to be able to help the team. I feel good. I knew that this season would be very important for me. I'm looking for my best version to help my team-mates and be more confident."
Lazio 2-2 Milan: Leao salvages draw but Rossoneri still winless
Rafael Leao came off the bench to earn Milan a 2-2 draw with Lazio at the Stadio Olimpico on Saturday, but Paulo Fonseca's side are still without a Serie A win this season.
Milan were in front at the break through Strahinja Pavlovic's eighth-minute goal, the Serbian rising highest to power home a header from Christian Pulisic's corner.
However, Lazio hit back in the second half with Valentin Castellanos and Boulaye Dia scoring in quick succession.
Nuno Tavares' first-time ball into the centre was met by the unmarked Castellanos to level in the 62nd minute, then Dia tapped another Tavares cutback home to put the Biancocelesti ahead four minutes later.
Fonseca reacted by sending on four substitutes, and those changes had a swift impact as three of them combined for the leveller.
Theo Hernandez – who joined Leao in being dropped from the start – picked out Tammy Abraham, and his lay-off allowed Leao to escape Tavares to fire past Ivan Provedel.
The game was preceded by an emotional tribute to the man who led Lazio to their last league title, Sven-Goran Eriksson, who died at the age of 76 on Monday.
A Lazio shirt bearing the Swede's name was displayed on the home bench, while a banner held up by the home fans read: "You brought us to the top of the world... Have a good trip Mr. Sven."
Data Debrief: Milan's slow start continues
New Milan boss Fonseca is already under pressure after overseeing a return of two points from his first three league games at the helm.
It is the first time the Rossoneri have drawn two of their opening three matches in a Serie A season since 2011-12, when they also drew two and lost one,
They went on to finish second that season, just four points adrift of champions Juventus. If a title challenge is to take place this term, rapid improvements are needed.
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