The Champions League knockout stages are renowned for delivering high drama, and that will be required if Liverpool and Eintracht Frankfurt are to progress to the last eight.
Both Liverpool and Eintracht face uphill battles to reach the quarter-finals having been comfortably beaten at home in the first legs of their respective last-16 ties.
Eintracht lost 2-0 to Napoli, while Liverpool have the task of overturning a 5-2 first-leg deficit against Real Madrid, the team who beat them in last year's final.
Although you can never count Liverpool out of any tie, the omens are squarely against either trailing side completing a comeback on Wednesday.
Here, Stats Perform previews the final two matches of the last 16 with the help of Opta numbers.
Napoli v Eintracht Frankfurt
Dominant in Serie A, Luciano Spalletti's Napoli already appear destined to claim their first Scudetto since 1990.
Should they finish the job at home in the second leg after victory in Frankfurt, they will make another piece of history.
Indeed, if they do progress, Napoli will reach the quarter-finals of the Champions League for the first time.
Hope for Eintracht comes from the 2011-12 season, the last time Napoli won a Champions League knockout match (3-1 v Chelsea). That was followed by a 4-1 defeat at Stamford Bridge and elimination from the competition.
But Napoli are unbeaten in their last 11 Champions League home games (W8 D3), and the odds of Eintracht stopping the hosts scoring appear slim.
Napoli have scored 22 goals in the Champions League this season – the last time an Italian side netted more in a single campaign (excluding goals in awarded victories, such as Milan in 2004-05) was in 2002-03, with Juventus scoring 30 and Inter netting 26. The form book favours Napoli turning Eintracht's already tough task into an impossible one.
Real Madrid v Liverpool
This will be Madrid's 300th match in the Champions League, at least 20 more than any other side since the 1992 rebrand, and Liverpool have a mountain to climb if they are to ruin the occasion.
Liverpool, of course, do have history of remarkable turnarounds in this competition. The Reds are one of just four sides to have progressed from a Champions League tie having lost the first leg by three or more goals, doing so against Barcelona in the 2018-19 semi-final (0-3 away, 4-0 home).
But Madrid are used to getting the job done at the Santiago Bernabeu. They have progressed from 26 of their previous 27 European Cup or Champions League knockout ties when winning the first leg away from home, with the exception being defeat to Ajax at this stage in 2018-19 (2-1 away, 1-4 at home).
If Liverpool are to deliver another second-leg performance for the ages, they will likely need to slow Vinicius Junior.
Vinicius has scored Champions League braces for Real Madrid against Liverpool at both Anfield and the Alfredo Di Stefano, Madrid's home while the Bernabeu was being renovated.
With this game taking place at the Bernabeu, he could become just the second player to score two or more goals against the same opponents in Champions League games at three different venues – after Cristiano Ronaldo against Juventus (Allianz Stadium, Bernabeu and Principality Stadium).
Having lost six of their last seven Champions League games against Madrid, Liverpool also have the issue of stopping Karim Benzema, who has scored 19 goals in his last 19 appearances in the knockout stages, while he is also the top scorer against Liverpool in European Cup and Champions League history (six).
Coventry City 2-3 Hull City: Tigers win five-goal thriller to keep play-off hopes alive
Hull City kept their hopes of gatecrashing the Championship play-offs alive with a thrilling 3-2 win over beaten FA Cup semi-finalists Coventry City on Wednesday.
Noah Ohio scored the winner with his first touch after coming on as a second-half substitute as Hull moved within three points of sixth-placed Norwich City with two games to play.
Coventry, meanwhile, saw their own hopes of returning to Wembley Stadium for a second successive play-off final all but ended, as they sit six points further back with three matches remaining.
Three days on from their remarkable comeback against Manchester United, the Sky Blues twice fought back to level things at Coventry Building Society Arena. Jaden Philogene's shot squirmed under goalkeeper Bradley Collins to put Hull ahead 31 minutes in, but Kasey Palmer levelled within five minutes with a stunning free-kick.
Hull went back ahead in controversial circumstances on the stroke of half-time, Liverpool loanee Fabio Carvalho converting from the penalty spot despite replays showing Joel Latibeaudiere's foul on Liam Delap took place outside the area.
Mark Robins' men again dragged themselves back into the game as Bobby Thomas headed Jay Dasilva's cross in just before the hour mark, but it was Liam Rosenior's visitors who found a winner.
Thomas went from hero to villain as his poor back pass sold Collins short, and Ohio got a toe to the ball to score the winner, keeping Hull's hopes of Premier League football intact.
Van Dijk: Liverpool have 'no chance' in title race after derby defeat
Virgil van Dijk conceded Liverpool might be out of the Premier League title race after they suffered a surprise 2-0 defeat to Everton in Wednesday's Merseyside derby.
Jarrad Branthwaite and Dominic Calvert-Lewin scored in either half to give the Toffees their first win over Liverpool at Goodison Park since 2010.
Liverpool struggled to find a way through the Toffees' defence despite dominating for long periods, and the Reds' captain says they will not outlast Arsenal and Manchester City without major improvements.
Speaking to Sky Sports, Van Dijk said: "If we play like today, then we have no chance to consider ourselves in the title race.
"We have to just focus on the next game and that will be a tough one anyway, so we will see.
"We're very disappointed, in so many ways. I think everyone has to look at their own performances. Did they really give everything, and do they really want to win the league?
"We're still fighting and there are still games after tonight, but if we play like we did overall in the game today – not winning challenges and giving the referee a chance to give free-kicks like he did many times, then you have no chance to win the title."
Howe: Newcastle performance in Palace defeat 'way off' Spurs win
Eddie Howe admitted Newcastle United's performance in the 2-0 loss at Crystal Palace on Wednesday was "way off" the one that saw them thump Tottenham in their previous game.
Howe's men hammered Spurs 4-0 in their last match, but they never got close to matching the attacking verve from that outing and a Jean-Philippe Mateta double condemned the Magpies to defeat at Selhurst Park.
Newcastle didn't even manage a shot on target until the 87th minute, accumulating just 0.42 xG (expected goals) as the likes of Alexander Isak and Anthony Gordon struggled to make an impact.
Only against Manchester City in August (one) have Newcastle recorded fewer shots on target in a Premier League game this season than their two against Palace, and Howe was critical of his team's display in the loss, one that all but ends their hopes of finishing in the top four.
"[It is a] bad day for us," Howe told Newcastle's club media.
"I thought we were disappointing today, especially in the first 60 minutes. We were way off our levels against Tottenham and our best levels.
"I thought technically we didn't deliver a good performance, and out of possession I don't think it was a particularly good performance either."
Newcastle were unlocked twice for Mateta to score by a Palace side who themselves only generated 0.88 xG.
Howe was left frustrated by the manner in which his side conceded, adding: "I think we'll be disappointed with our performance technically today, and that's probably epitomised by the two goals where we're disappointed with how we've given them the ball in those situations and then how we defended.
"I think the goals sum up aspects of our performance where there was some good, lots of moments that could have led to opportunities, but we were slow to shoot around the box," he said.
The defeat, combined with Manchester United's 4-2 win over Sheffield United, means Newcastle drop to seventh, while eighth-placed West Ham are two points behind with a game in hand.
Newcastle have now lost eight of their last 11 Premier League away games, while they have lost on four occasions in London in the league this term, only doing so more times in a Premier League season in 2000-01 and 2005-06 (both five).
It's been a disappointing season for Howe and his side, especially compared to the heroics of last term when Newcastle finished in the top four, and the Magpies boss knows there's work to be done to get back to those levels.
"It's a day that we have to take our punishment, deal with it, and then try and improve," Howe continued. "It's frustrating because we know we're capable of much better."
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