Sergi Roberto accepts Barcelona "have a problem in midfield" ahead of their return leg at Manchester United due to Pedri and Gavi being ruled out.
The sides played out a thrilling 2-2 draw at Camp Nou on Thursday to leave their Europa League play-off tie in the balance heading into next week's second leg.
Barca rallied from behind, having earlier let slip a lead of their own, but it came at a cost as Pedri limped off with a hamstring injury that is expected to rule him out for a month.
Meanwhile, fellow central midfielder Gavi received a yellow card, with that his third in Europe this season, resulting in an automatic suspension for the game at Old Trafford.
Xavi's options are further limited as Sergio Busquets is also nursing an injury, but versatile defender Sergi Roberto is happy to fill the void if called upon.
"We hope that Pedri's injury won't be too serious, so he can be back on the pitch as soon as possible," Sergi Roberto said.
"But it's true that we have a problem in midfield now, especially in the Europa League, because Gavi can't play. We don't know yet if Pedri can.
"I will be willing to play in any position the coach wants me to. Either in the midfield or as winger. The coach knows I am at his disposal for wherever he needs me."
Pedri in particular has been hugely influential for Barca this season, with no player in LaLiga winning more points for their side (10 points with six goals).
The youngster left the field against United with the game still goalless, but Marcos Alonso opened the scoring for Barca early in the second half.
Marcus Rashford's 22nd goal of the season – equalling his career-best tally in the 2019-20 campaign – and a Jules Kounde own goal had United in front nine minutes later.
But Raphinha levelled for the hosts in rather fortuitous circumstances in the 76th minute to leave the tie delicately poised ahead of the return match in Manchester.
"A win wasn't to be, so to draw is better than losing," Sergi Roberto said. "My team really competed right until the end.
"It's true that when you have a win in the bag, the second leg looks better. It was a night when both teams had lots of chances. Next week we'll have to improve.
"United are a team who love having the ball and that's made it a very interesting match. What a shame we couldn't win it."
LaLiga leaders Barcelona are now unbeaten in all six of their home games against United (W3 D3).
Raphinha hails Barcelona after statement win over Valladolid
Barcelona forward Raphinha believes the team have laid down a statement of their intent by starting the season with four straight wins in LaLiga.
Raphinha scored the first hat-trick of his career and also delivered two assists on Saturday, as Barca crushed Real Valladolid 7-0 at Camp Nou.
Hansi Flick's side already possess a four-point cushion at the top of the table after also recording victories over Valencia, Athletic Bilbao and Rayo Vallecano.
Raphinha believes their results have demonstrated the club got things right in the transfer market, telling Movistar: "Today's game has shown that there is no need for anyone else to come. We are very happy because of that.
"We are in very good shape. The team is working hard. Today's result shows what we are working for.
"We saw that the coach was on the sidelines asking for more goals and that's our mentality.
"We are hungry and want to score as many goals as we can. When we are dominant like we have been, the best way to respect our rivals is not taking the foot off the gas."
Raphinha was one of the players who faced criticism during Barca's trophyless 2023-24 campaign and was rumoured to be on his way out ahead of the new season.
The Blaugrana again battled financial restrictions throughout the window, allowing Ilkay Gundogan to leave in order to secure the registration of new arrival Dani Olmo.
With his future now certain, Raphinha is keen to nail down a starting spot and contribute on a regular basis.
"I don't know if today's was my best game, but it's certainly among my best. I will try to play even better and as much as I can," the Brazilian said.
"I'm very happy to be able to help the team. I feel good. I knew that this season would be very important for me. I'm looking for my best version to help my team-mates and be more confident."
Bayer Leverkusen 2-3 Leipzig: Visitors fightback halts unbeaten streak for Alonso's side
Bayer Leverkusen suffered their first defeat in 36 Bundesliga matches, as Leipzig came from behind to stun Xabi Alonso's side 3-2 at BayArena.
Lois Openda struck twice for Marco Rose's, who recovered from 2-0 down to make it two wins from two and move to the summit of the table.
It looked like business as usual for the reigning Bundesliga champions when they scored twice in the last seven minutes of the first half through Jeremie Frimpong and Alejandro Grimaldo.
However, Leipzig replied deep into first-half stoppage time with Kevin Kampl reducing the deficit.
Openda then brought the visitors level in the 57th minute, before a stunning long-range strike completed the turnaround 10 minutes from time, condemning Leverkusen to their first league defeat in 15 months.
Data Debrief: Leverkusen's long streak comes to a shuddering halt
Leipzig became the first side to beat Leverkusen in a Bundesliga match since Bochum achieved the feat a staggering 462 days earlier.
The visitors have begun a Bundesliga season with two wins from two for only the second time, also doing so in 2019-20.
They are also now unbeaten in 13 league matches, their longest such streak since Rose took charge.
As for Leverkusen, their invincible streak is officially history, as is their 29-game unbeaten run on home soil.
Sancho given fresh start with Chelsea loan move
Jadon Sancho has secured a move away from Manchester United, having joined Chelsea on Deadline Day on a season-long loan.
The deal includes an obligation to buy for between £20-£25 million at the end of the loan, according to widespread reports, meaning that the 24-year-old will not be returning to Old Trafford next summer.
Work to complete the transfer came late on Deadline Day, with a deal sheet being submitted to ensure the signing could go through after the 11pm deadline.
Chelsea were able to get the deal over the line, confirming the move was complete on Saturday evening.
"I’m really excited to be here," Sancho said. "London is where I grew up and I’m happy to be back.
"The manager spoke to me about the project and, for a young player, it's exciting. Hopefully I can bring goals and assists to the Bridge."
It brings an end to a three-year spell at Old Trafford for Sancho. The winger originally joined United on a five-year contract in 2021 but, following a public falling out with manager Erik ten Hag, found his first-team opportunities limited.
Sancho made 83 appearances in all competitions for United, but his last start for the club came against Manchester City in the 2023 FA Cup final. He made three substitute appearances in August 2023 before moving back to Dortmund on loan in January, where he scored three goals in 21 appearances.
His final outing in a United shirt came off the bench in their Community Shield defeat to Manchester City, but he was not included in the squad for the first two league games.
Sancho joins a club with plenty of competition for attacking places, with Cole Palmer, Christopher Nkunku, Nicolas Jackson, Pedro Neto, Joao Felix and Noni Madueke among their roster.
Chelsea did also manage to move some players on during Deadline Day. Raheem Sterling secured a loan move to Arsenal on Deadline Day, while Trevoh Chalobah joined Crystal Palace, Armando Broja moved to Everton and Djordje Petrovic was loaned by Strasbourg.
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