Manchester City make the trip to Arsenal on Wednesday with the opportunity to move top of the Premier League table at the expense of their opponents for the first time in over three months.
Not since November 6, when Arsenal beat Chelsea at Stamford Bridge with another statement victory, has a side other than the Gunners led the way at the summit.
But after only two wins in their past five matches for Arsenal, and three wins in four for City, a gap that stood at eight points less than a month ago has been cut to just three ahead of their showdown at Emirates Stadium.
Arsenal still have a game in hand, while the sides also still have to face off again at the Etihad Stadium in April, but the signs are pretty ominous as City chase down a fifth league title in six seasons.
A positive result for Arsenal in midweek in front of their supporters would change that perspective, but meetings between these sides over the past five seasons have only gone one way.
Ahead of their top-of-the-table tussle in north London, Stats Perform looks at Arsenal's terrible record in this fixture in more detail and whether another defeat would pave the way for yet another City title.
TEN IN A ROW FOR CITY
Not since Arsenal's most recent title tilt, back in 2015-16 when Leicester City pulled off the shock of all shocks, have they defeated Manchester City in the Premier League.
The fact Theo Walcott was on target for Arsenal in that December 2015 win, along with the evergreen Olivier Giroud, with Mesut Ozil the man pulling the strings in midfield, goes a long way to highlighting just how long ago that rare triumph was.
Since then, Arsenal have failed to beat City in 13 attempts in the top flight, losing the past 10 of those. Needless to say, that stretch of defeats is their worst run against any opponent in the competition's history.
Indeed, should they lose again on Wednesday, only four teams in Premier League history will have lost more times on the bounce against a single opponent.
That is not to say Arsenal haven't had any joy in this fixture in recent years, having defeated City en route to winning the FA Cup in the 2016-17 and 2019-20 campaigns.
Normal service was resumed, though, when the Citizens saw off a much-changed Arsenal 1-0 in last month's fourth-round tie.
KEEP YOUR COOL
City's remarkable run in this fixture includes six straight wins at Emirates Stadium in all competitions – as many victories as in their previous 61 visits to Arsenal and one short of setting an outright record for most wins in a row away to the Gunners by any club.
But exactly why is it that Arsenal have fared so badly against City, despite having Arsene Wenger, Unai Emery, Freddie Ljungberg and now Arteta in the dugout across their 10-game losing run?
The Gunners were on the end of a 5-0 thrashing in their last league visit to the Etihad Stadium in August 2021, though they put up far more of a fight in losing 'only' 2-1 when the sides met in London on New Year's Day last year.
That game is best remembered for Rodri scoring a winner in the third minute of stoppage time for City, a dramatic end to an incident-packed encounter after Arsenal had Gabriel Magalhaes dismissed for an avoidable red card.
Even then it was clear Arteta's patient work was paying off at Arsenal; though despite performing well, a fifth successive loss against his former club had a sense of inevitability about it for the Spaniard.
Gabriel's sending-off changed the complexion of that contest, while Granit Xhaka's dismissal opened the floodgates for City in their five-goal hammering in last season's other encounter.
TIME FOR A CHANGE?
Keeping 11 players on the field will be a good start for Arsenal if they are to finally take a point or more off City, but will Arteta be tempted to – as we have seen countless times from his mentor Guardiola – change things up?
That might make sense after going two games without a Premier League win for the first time this season, especially considering Arteta has named an unchanged team for six straight games.
Never before have Arsenal stuck with the same line-up for seven games in the competition, and with January recruits Leandro Trossard and Jorginho among those pushing for starts, maybe that record will stay intact for a bit longer.
Perhaps this goes beyond personnel and formation, though. For if Arsenal are to end their City jinx, they need to overcome a mental barrier that's seen Guardiola have his own way for the past five years in league meetings.
Given the fine margins, it's difficult to bill the two meetings between the sides over the next 10 weeks as anything other than title deciders.
Unbeaten in 13 home league matches – their best run since the 2018-19 season – and up against a City side on a two-game losing streak on their travels, it really does feel like now or never for Arsenal.
"The conditions next season won't be as favourable for Arsenal," legendary former Gunners boss Arsene Wenger said in the days leading up to the biggest Premier League game of the season. "So let's not waste this opportunity."
Overcome their City hoodoo on Wednesday and Arsenal truly will be favourites to land a first title since 2003-04 under Wenger; suffer another defeat and City's ascent towards another title under Guardiola will be in full swing.